Chng 9.

THUC BT CM
PHN I. THUC BT
Mc tiu hc tp:
1.

Trnh by c vai tr, v tr ca bt thuc trong cc dng thuc rn.

2.

Trnh by c phn loi, u, nhc im, cc t dc s dng trong

thuc bt.

3.

Nu c cc c tnh ca bt thuc vn dng trong k thut bo ch

v sinh dc hc cc dng thuc rn.

4.

M t c qu trnh bo ch bt thuc qua 2 giai on: nghin v

ry.

5.

Nu c k thut iu ch bt kp qua 2 giai on: nghin bt n

v trn bt kp.

6.

Phn tch c mt s cng thc thuc bt.

I. I CNG
1. nh ngha
Cu 1. Phn bit khi nim thuc bt v bt thuc?
Cu 2. Trnh by mi lin quan gia thuc bt v cc dng thuc rn khc?
2. Phn loi
2.1. Da vo thnh phn
T dc thuc bt:
V d:
CLAMOXYL (SMITHKLINE BEECHAM)
Bt pha siro 250 mg/5 ml:

cho 5 ml

Amoxicillin trihydrat

250 mg

T dc: crospovidone, aspartam, magnesi stearat, gm xanthan, natri carboxy

methyl cellulose, silic dioxyd keo khan, natri benzoat, hng thm "chanh-o-du".
Cu 3. Yu cu ca bt pha siro?
Cu 4. Cu trc ca siro ny (dung dch, hn dch, nh tng)?
Cu 5. Cc t dc cn c cho bt pha siro ni ring v thuc bt ni chung?
Cu 6. Vai tr ca cc thnh phn trong cng thc?
2.2. Da vo cch phn liu, ng gi
2.3. Da vo kch thc tiu phn
Phn loi theo KTTP: xem DVN IV (khc SGK).

2.4. Da vo cch dng

3. u, nhc im
II. THNH PHN THUC BT
1. Dc cht
2. T dc (xem thm phn vin nn)
III. K THUT NGHIN - RY
1. Nghin bt
2. Ry
3. Mt s c tnh ca tiu phn dc cht rn vn dng trong bo ch
3.1. Kch thc tiu phn
3.2. Hnh dng tiu phn
3.3. Dng th hnh
3.4. Lc lin kt tiu phn
3.5. trn chy ca khi bt
3.6. xp ca tiu phn
3.7. xp ca khi bt
3.8. Khi lng ring
3.9. Kh nng chu nn
Cu 7. in vo bng sau:
c tnh

Phng php nh gi

nh hng n
bo ch v SKD

Vn dng

...

...

...

...

Cu 8. X l tnh hung sau:

Bt pha hn dch ampicilin khi dng cho bnh nhn thy sinh kh dng thp v
khng n nh. Hy nu cc nguyn nhn c th gy ra hin tng ny v bin php khc
phc.
IV. K THUT BO CH THUC BT
1. Nguyn tc bo ch bt kp
Cu 9. Nu cc bin php lm tng s ng u v phng php kim tra ng
u khi trn bt kp.
2. Bo ch mt s bt kp c bit
Mt s v d:
PAPS (Laboratoires M. RICHARD SA)
Lu hunh

8,5 g

Km undecylenat

1,0 g

Bismuth gallat base

0,5 g

Menthol

0,5 g

Camphor

1,0 g

Acid salicylic

0,5 g

Km oxyd

9,0 g

Acid boric

9,0 g

Tinh du hoa mi
Talc

0,25 g
v

100,0 g
BT DNG NGOI

Triclosan

3,0 mg

Km undecylenat

2,0 mg

Menthol

0,2 mg

Talc

926,8 mg

Magnesi stearat

30,0 mg

Tinh bt ng

30,0 mg

Cht thm

8,0 mg
ORACFAL (BRISTOL-MYERS SQUIBB)

Bt pha siro:
Cho 5 ml

Cho 1 l

Cefadroxil monohydrat
(tnh theo dng khan)

500 mg

6g

T dc: natri benzoat, Avicel, polysorbat 40, saccarose, cht thm.

HPARGITOL (LERT)
Sorbitol

2,723 g

Acid citric

0,878 g

Arginin clohydrat

0,5 g

Natri sulfat khan

0,066 g

Natri hydrophosphat

0,119 g

T dc: natri hydrocarbonat, saccarose, tinh du cam, tinh du chanh.

BT PHA HN DCH AMOXICILIN V KALI CLAVULANAT

1 chai cha:
Amoxicilin trihydrat

1500,00 mg ( 1250 mg amoxicilin)

Kali clavulanat

393,60 mg

Gm xanthan

150,00 mg

Hydroxypropyl methylcellulose 1800,00 mg

Natri saccharin

150,00 mg

Silic dioxyd dng keo khan

300,00 mg

Acid succinic

10,00 mg

T dc hng o

183,60 mg

T dc hng du

236,40 mg

T dc hng chanh

731,14 mg

Mt chai pha c 60 ml hn dch m c 5 ml th cha 125 mg amoxicilin v 31,25

mg acid clavulanic (tnh qui i).
BT PHA HN DCH AZITHROMYCIN
Cng thc cho 1 chai c vch 30 ml:
Azithromycin dihydrat
Saccarose

1,263 g
23,169 g

Trinatri phosphat

0,108 g

Natri benzoat

0,090 g

Hydroxypropyl cellulose (Klucel EF)

0,015 g

Gm xanthan

0,015 g

T dc mi anh o

0,090 g

T dc mi vani

0,200 g

T dc mi chui

0,150 g

V. NG GI V BO QUN THUC BT
Cu 10. ng gi thuc bt dng ngoi khc thuc bt ung nh th no?
Cu 11. ng gi thuc bt phn liu khc thuc bt cha phn liu nh th
no?
VI. NH GI CHT LNG THUC BT
Cu 12. Trong cc ch tiu cht lng ca thuc bt, ch tiu no lin quan trc tip
n sinh kh dng, ch tiu no lin quan trc tip n n nh ca ch phm? Nu
phng php nh gi cc ch tiu ny?

PHN 2. THUC CM
Mc tiu hc tp:
1.

K tn c cc loi t dc dng bo ch thuc cm.

2.

Trnh by c k thut bo ch thuc cm.

Cu 1. T dc v phng php bo ch thuc cm c g khc so vi thuc bt?
Cu 2. La chn t dc v trnh by k thut bo ch thuc cm aspirin.
THUC CM ACECLOFENAC
Cng thc cho 1 ti:
Aceclofenac
T dc mi cam
Sorbital

50,00 mg
165,83 mg
3292,30 mg

Lutrol F 68 (poloxamer)

169,23 mg

Cremophor RH 40

169,23 mg

Nc kh khong

2 ml

THUC CM ACETAMINOPHEN V DIPHENHYDRAMIN

HYDROCLORID
Cng thc cho 1 ti:
Acetaminophen (bt siu mn)

1650,00 mg

Diphenhydramin hydroclorid

250,00 mg

FD&C Yellow No. 10 Lake

FD&C Red No. 40

0,90 mg
0.0005 mg

Saccarose

18081,10 mg

Aspartam

200,00 mg

Tinh bt ng

250,00 mg

Acid citric

180,00 mg

Natri citrat

38,00 mg

Natri clorid

200,00 mg

T dc mi mt ong

240,00 mg

T dc mi chanh

100,00 mg

Nc tinh khit

va

THUC CM SI BT ACETAMINOPHEN, DOXYLAMIN V CAFEIN

Cng thc cho 1 ti:
Acetaminophen

500,00 mg

Doxylamin succinat

5,00 mg

Cafein

33,00 mg

Acid tartaric

391,00 mg

Natri hydrocarbonat

417,00 mg

Kollidon 30

6,00 mg

Isopropanol (hoc ethanol)

va

Natri citrat

30,00 mg

Saccarose

707,00 mg

THUC CM PHA HN DCH ERYTHROMYCIN ETHYLSUCCINAT

Cng thc cho 1 kg:
Erythromycin ethylsuccinat

55,860 g

Saccarose

823,840 g

Natri citrat

95,095 g

Natri saccarin

1,128 g

FD&C Red No. 40

0,104 g

Natri carmellose (Sodium CMC 7 MFD)

0,543 g

Nh tng simethicon 30% (Simethicone M30)

8,151 g

Gm xanthan

4,932 g

T dc hng anh o

2,382 g

Nc tinh khit

15,200 g

ng 52,5 g cm vo chai c vch 100 ml.

THUC CM MULTIVITAMIN
Cng thc cho 1 ti:
Bt vitamin A+ D (50.000 IU/g) (BASF)

40,00 mg

Thiamin mononitrat (BASF)

5,00 mg

Riboflavin (BASF)

6,00 mg

Nicotinamid

22,00 mg

Pyridoxin hydroclorid (BASF)

4,50 mg

Calcium D-pantothenat (BASF)

30,00 mg

Cyanocobalamin (di dng vi nang bao bi 0,1% gelatin)

Bt acid ascorbic (BASF)

0,013 mg
230,00 mg

Bt vitamin E acetat

42,00 mg

Saccarose, nghin mn

4000,00 mg

Kollidon CL-M

1000,00 mg

T dc mi cam

200,00 mg

Kollidon VA 64

400,00 mg

Ethanol hoc isopropanol

1,40 ml

THUC CM PHA SIRO NHM HYDROXYD V MAGNESI CARBONAT

Gel kh nhm hydroxyd

200,00 g

Magnesi carbonat base

200,00 g

Kollidon CL-M

240,00 g

Sorbitol, tinh th

211,50 g

T dc mi cam

41,30 g

Kollidon 30

82,60 g

T dc mi da

3,30 g

T dc mi chui

4,13 g

Natri saccarin

4,13 g

Nc tinh khit

8,26 g

Khi dng lc 58 g ch phm vi 100 ml nc si ngui.