PHN I.

VIN NN
MC TIU HC TP
1. Trnh by c vai tr, c ch tc dng v xu hng nh hng ti kh nng
gii phng dc cht ca 5 nhm t dc: n, dnh, r, trn, bao.
2. Nu c u nhc im v cch dng ca cc t dc c th thuc 5 nhm
ni trn.
3. La chn c t dc cho mt cng thc vin nn.
4. Vit c quy trnh bo ch vin nn theo 3 phng php: dp vin qua to
ht t, to ht kh v dp thng.
5. Nu c mc ch bao vin v cc phng php bao.
6. Trnh by c tiu chun cht lng vin nn v cch nh gi.
7. Trnh by c cc yu t nh hng n sinh kh dng vin nn v bin
php nng cao sinh kh dng.
I. I CNG
1. V tr vin nn
Xem nh ngha vin nn trong SGK v DVN IV.
2. Phn loi vin nn
Theo phng php sn xut:
+ Vin nn dp thng
+ Vin nn dp qua to ht: t, kh
Theo hnh thc bn ngoi:
+ Vin nn trn
+ Vin nn bao: ng, film
Theo cch s dng:
+ Vin nut, ngm cy, t, pha dung dch, hn dch...
3. u - nhc im ca vin nn: SGK
Vin nn l dng bo ch ph bin nht: ti sao?
Vin nn cng l dng bo ch c nhiu vn v sinh kh dng nht: ti sao?
II. K THUT BO CH VIN NN
1. La chn t dc xy dng cng thc dp vin
- Cc yu t cn xem xt?
- Yu cu chung ca t dc vin nn?
i vi mi t dc cn ch :
- Ngun gc, bn cht l, ho hc
- Tnh cht
- Cch s dng
- n nh
- Tng k vi cc thnh phn khc
- an ton
- Gi thnh
- nh hng ca t dc n c tnh vin nn, SKD v n nh ca
vin.
1.1. T dc n (fillers, diluents)
1.1.1. Nhm t dc n tan c trong nc
- Lactose

Manitol
Sorbitol
Bt ng (saccarose)
Emdex v Celutab: tinh bt thu phn (90 92% dextrose, 3 5%
maltose), trn chy tt, d ht m, phn ng vi cc cht c nhm amino.
Thng dng cho vin nhai (do c v ngt).
- Dextrates USP (Emdex): 93 99% dextrose. Vin nn cha dextrates tng
lc gy v vin sau vi gi sn xut nhng sau khng tng. Tng k:
cht cha nhm amino, tc nhn oxy ho.
- Inositol: hay dng cho vin nhai.
1.1.2. Nhm t dc n khng tan trong nc
- Tinh bt
- Dextrin
- Tinh bt bin tnh (cc loi...)
- Cellulose bt
- Cellulose vi tinh th (Avicel, Emcocel, Vivacel)
- Calci carbonat, magnesi carbonat
- Cc mui calci phosphat

Mt s t dc n dng cho vin nn dp thng: phi c kh

nng trn chy v chu nn tt.
Nhm tan trong nc
Lactose:
- Lactose phun sy: lng dng > 80%, t ht m.
- Fast-Flo lactose
- Tablettose
- Lactose khan
- Ludipress: c cha lactose, Kollidon 30 v Kollidon CL
Saccarose:
- Di-Pac: hn hp ng kt tinh ca 97% saccarose + 3% highly modified
dextrins.
- Nutab: saccarose x l, 4% invert sugar (hn hp ng phn t ca
levulose v lactose), 0,1 - 0,2% tinh bt ng v magnesi stearat.
Dextrose:
- Emdex (spray-crystallized): 90 92 % dextrose, 3 5% maltose, phn cn li
l glucose polysaccarid cao hn. C kch thc tiu phn ln nht trong s cc
t dc dp thng.
Sorbitol:
- Sorbitol 834
- Neosorb 60
Manitol: lm vin khng cng nhng t ht m hn so vi khi s dng sorbitol.
Maltodextrin:
- Maltrin: chu nn tt, tan hon ton, rt t ht m.
Nhm khng tan trong nc:
Tinh bt:
- Starch 1500: c hm m cao (12 13%).
Cellulose:
- Avicel: ht m lng lin kt H gim cng vin.
- Emcocel

Microfine cellulose (Elcema): trn chy v chu nn km hn cellulose vi tinh

th.
Mui calci v c:
- Calci hydrophosphat (Emcompress, Ditab): r, t ht m, t chu nn hn
Avicel.
- Tricalci phosphat (TriTab)
- Calci sulfat dihydrat
- Cel-O-Cal: 30% cellulose vi tinh th + 70% calci sulfat khan ng phun sy.
- Calci carbonat: c ng x l vi cc t dc dnh khc nhau.
1.2. T dc dnh (binders)
Mt s t dc dnh
T dc
Gm arabic
Dn cht cellulose
Gelatin
Gelatin-gm arabic
Glucose
Polymethacrylat
PVP
H tinh bt
Saccarose
Sorbitol
Tinh bt bin tnh
Tragacanth
Natri alginat

Nng s dng (%)

10 25
5 10
10 20
10 20
25 50
5 15
3 15
5 10
50 75
10 25
25
3 10
35

Nng trong
cng thc vin (%)
25
15
15
25
2 25
5 20
25
15
2 25
2 10
1 10
14
2 5

1.2.1. Nhm t dc dnh lng

- H tinh bt
- Dch th gelatin
- Dch gm arabic
- Dung dch polyvinyl pyrolidon (PVP)
- Dn cht cellulose (L-HPC, HPMC, NaCMC, EC...)
- Polymethacrylat (Eudragit NE30D, RS30D)
- T dc dnh kt hp
T dc dnh dng cho phng php xt ht t
T dc dnh
Tinh bt ng, USP
Pregelatinized cornstarch
Starch 1500
Gelatin
Saccarose
Gm arabic
PVP

Nng thng dng

H 5 10%
Dung dch 5 10% trong nc
H 5 10%
Dung dch 2 10% trong nc
Dung dch 10 85% trong nc
Dung dch 5 20% trong nc
Dung dch 5 20% trong nc, ethanol,
alcol khc

MC
NaCMC ( nht thp)
EC
PVA
PEG 6000

Dung dch 2 10% trong nc

Dung dch 2 10% trong nc
Dung dch 2 15% trong ethanol
Dung dch 5 20% trong nc, ethanol,
alcol khc
Dung dch 10 30% trong nc, ethanol,
alcol khc

1.2.2. Nhm t dc dnh th rn

- Lactose phun sy
- Bt PVP
- Bt CMC
- Cellulose vi tinh th
1.3. T dc r (disintegrants)
- Vai tr ca s r i vi SKD vin nn?
- Cc c ch r?
- Cch phi hp t dc r vo vin: r trong/ r ngoi?
6 nhm t dc r:
- Tinh bt
- Clays
- Celluloses
- Algins
- Gums
- Miscellaneous: cht din hot, natural sponge, resins, effervescent
mixtures, hydrous aluminum silicat, cross-linked PVP (Povidone-XL:
super disintegrant).
Cc loi t dc r hay dng:
- Tinh bt
- Sodium starch glycolate (Primojel, Explotab)
- Avicel
- Cellulose v dn xut (MC, NaCMC, CMC)
- Veegum (nhm magnesi silicat)
- Alginates
Cc t dc siu r
Kiu cu trc (tn)
M t
1. Tinh bt bin tnh Sodium
carboxymethyl
(sodium
starch starch;
cc
nhm
glycolate)
carboxymethyl lm tng
tnh thn nc v cc lin
kt cho lm gim tan.
2. Cellulose bin tnh Sodium
carboxymethyl
(croscarmellose)
cellulose; cc lin kt cho
lm gim tan.

Tn thng mi (nh sn xut)

Explotab (Edward Mendell Co.)
Primojel (Generichem Corp.)
Tablo (Blanver, Brazil)

AcDiSol (FMC Corp.)

Nymcel ZSX (Nyma, Netherlands)
Primellose (Avebe, Netherlands)
Solutab (Blanver, Brazil)
3. Cross-linked poly- Cross-linked
Crospovidone M (BASF Corp.)
vinylpyrrolidone
polyvinylpyrrolidone; khi Kollidon CL (BASF Corp.)
(Crospovidone)
lng phn t ln v cc Polyplasdone XL (ISP Corp.)

lin kt cho lm gim

tan.

Cch s dng ca mt s t dc r
T dc r
Tinh bt, USP
Starch 1500
Avicel PH 101, PH 102
Solka floc (cellulose g tinh ch)
Acid alginic
Explotab (sodium starch glycolate)
Gm guar
Polyclar AT (PVP, crosslinked PVP)
Amberlite IPR 88 (nha trao ion)
MC, Na CMC, HPMC

Lng s dng trong ht (%)

5 20
5 15
5 15
5 10
28
28
0,5 5
0,5 5
5 10

1.4. T dc trn
T dc trn c th chia lm 3 loi theo 3 cch tc dng:
- Cc cht lm gim ma st (lubricants): gim ma st gia ht v thnh ci.
Chy lm cn lc nn cao hn v nhiu t dc trn hn. Kch thc ht cng nh
cn cng nhiu t dc trn. Dng khng qu 1%.
- Cc cht chng dnh (antiadherents): chng dnh chy ci.
- Cc cht ci thin kh nng trn chy (glidants): ci thin kh nng trn chy
ca ht.
Nhng vn cn xem xt khi la chn t dc trn:
- Nhiu t dc trn c bn cht s nc, c th lm chm qu trnh thm
nc vo vin v lm gim r v ho tan dc cht.
- TD trn c th lm gim c tnh lin kt ca nhiu TD.
- Thi gian trn TD trn thng khng qu 10 pht.
- Cn xc nh lng TD trn ti u cho mi cng thc.
- TD trn phi c ry qua ry 125 180 m trc khi trn vo ht.
Vai tr ca t dc trn?
Cc cht lm gim ma st khng tan trong nc
T dc
Cc stearat (Mg, Ca, Na)
Acid stearic
Du thc vt hydrogen ho (Stearotex, Duratex)
Talc
Sp
Stearowet C (Ca stearat + Na lauryl sulfat)
Du khong nh
Tinh bt

Lng s dng (%)

0,25 2
0,25 2
0,25 2
15
15
15
13
5 10

Cc cht lm gim ma st tan trong nc

T dc
Na benzoat
Acid boric
Na benzoat + Na acetat
Na clorid
DL Leucine
Carbowax 4000, bt mn
Carbowax 6000, bt mn
Na oleat
Na acetat
Na lauryl sulfat
Mg lauryl sulfat

Lng s dng (%)

25
5 20
25
25
13
13
Cc cht chng dnh

T dc
Talc
Tinh bt ng
Cab-O-Sil
Syloid
DL Leucine
Na v Mg lauryl sulfat
Acid stearic, bt mn
Stearat
Stearowet C
Du hydrogen ho (Stearotex, Duratex)
Du khong nh
Natri benzoat
Natri clorid
PEG 4000 v 6000, bt mn

Lng s dng (%)

15
3 10
0,1 0,5
0,1 0,5
3 10
13
13
<2
0,5 2
1 3%
13
25
5 20
25

Cc cht lm tng kh nng trn chy

T dc
Talc
Tinh bt ng
Cab-O-Sil
Syloid
Aerosil
Calci stearat
Magnesi stearat
Stearowet C
Km stearat
Calci silicat
Tinh bt 1500
Magnesi lauryl sulfat
Magnesi carbonat nng
Magnesi oxid nng
1.5. T dc bao
1.5.1. T dc dng bao ng

Lng s dng (%)

15
5 10
0,1 0,5
0,1 0,5
13
0,5 2
0,2 2
0,2 2
0,2 1
0,5 2
1 10
0,2 2
13
13

1.5.2. T dc dng bao mng mng (film)

Polyme to mng:
Bao bo v dc cht: HPMC, Eudragit E, HPC...
Bao thay i gii phng dc cht:
Bao tan rut: Eudragit L. Eudragit S, CAP, HPMCP, Shellac...
Bao gii phng ko di: EC, Eudragit RL, Eudragit RS...
Cht lm do:
Tan c trong nc: triacetin, TEC, PEG, glycerin, propylen glycol...
t tan trong nc: du thu du, DBP, DEP, DBS...
Cht chng dnh: talc, magnesi stearat, Aerosil...
Cht din hot: polysorbat, natri lauryl sulfat...

Cht mu: mu khng tan trong nc (lakes) thng cho mu bao c mu

u v p hn mu tan trong nc (dyes).
Dung mi: ethanol, aceton, nc...
1.6. T dc mu
- Mu tan trong nc (dyes)
- Mu khng tan trong nc (lakes)
So snh hai nhm cht mu trn v cc mt: u nhc im, cch s dng.
1.7. T dc iu hng, v
1.8. T dc ht (hp ph)

Bi tp p dng:
La chon t dc thch hp cho cc vin nn sau:
1.
Vin nn paracetamol 325 mg
2.
Vin nn vitamin C 100 mg
3.
Vin nn vitamin B1 10 mg
4.
Vin bao tan rut aspirin 100 mg
5.
Vin nn ampicilin 250 mg
6.
Vin pha hn dch Co - trimoxazol

2. Dp vin
- Cc giai on chnh trong qu trnh dp vin? Cc thng s cn kim sot
trong tng giai on? Cc thng s ny nh hng nh th no n cht lng
thnh phm?
- So snh u nhc im ca ba phng php dp thng, dp vin qua to ht
kh, dp vin qua to ht t v cc mt: kh nng chu nn, trn chy,
phn b kch thc ht dp vin, cht lng vin lng ca vin, phm vi p
dng, thit b s dng, t dc s dng.
- Nu mc ch to ht, cc giai on chnh ca hai phng php to ht.
- Cc kh khn khi dp vin v bin php khc phc? (Vin b bong mt, st
cnh, dnh chy ci, kh nh vin, mt vin khng bng, khng ng u khi
lng, c bn c hc thp, khng t r, ho tan...).
Bi tp p dng:
C th dng nhng phng php no bo ch cc vin nn sau? u nhc
im khi p dng cc phng php :
1. Vin nn paracetamol 0,325 g
2. Vin nn aspirin 0,5 g
3. Vin nn vitamin C 0,5 g

4. Vin nn ampicilin 0,25 g

3. Bao vin
- Mc ch bao vin l g?
3.1. Bao ng
- u nhc im?
- Phm vi p dng?
- T dc s dng?
- Cc giai on chnh?
- Kh khn v cch khc phc?
V d v cng thc dch bao ng: phn tch vai tr ca cc thnh phn trong
cng thc? Nu cch pha ch v cch s dng dch bao ny bao vin?
Dch bao lt

Dch bao nn

Bt bao nn

Dch bao nhn/mu

Dch bao bng

Cellulose acetat phtalat

Propylen glycol
Methylen clorid
Ethanol
Gelatin
Gm arabic
ng knh
Nc ct
Bt ng
Bt gm arabic
Tinh bt ng
Talc
Cht mu
Bt bao nn
Bt ng
Nc ct
Sp carnauba
Sp ong
Parafin
Naphta

175 g
52,5 g
840 ml
v 1750 ml
60 g
60 g
1500 g
1000 ml
4,1 kg
0,12 kg
1,35 kg
0,23 kg
v
22,7 kg
136 kg
76 kg
0,09 kg
0,09 kg
0,02 kg
3,785 l

3.2. Bao mng mng (bao film)

- u nhc im?
- Phm vi p dng?
- T dc s dng i vi tng mc ch bao: bo v, bao tan rut, bao ko
di tc dng.
- Yu cu i vi vin nn em bao?
- Cc giai on chnh?
- Kh khn v cch khc phc?
Chun b:
- Tnh lng cht bao cn s dng Cng thc dch bao.
- Pha ch dch bao.
- Chun b vin.
Bao:
- Phun dch bao.
- o u vin.

Sy kh vin.
Thit b: ni bao thng, ni bao ci tin, my tng si.
Kh khn khi bao vin:
Vin b dnh: xem li tc phun dch, tc sy kh, cng thc dch bao.
Mng bao b bong: dch bao khng lan rng trc khi sy kh do sy kh qu
nhanh hay nht dch bao cao Cn pha long dch bao.
- Mng bao x x: phun thnh git, nng polymer, cht rn cao.
- m vin, khng u mu.
- Mng bao b rch, nt, co ko: thm hoc thay i cht lm do.
- Mng bao m: nhit qu cao lm bin tnh polymer.
- Khuyt tt g: vin c g, mi mn cao, mng bao gin.
Mt s cng thc dch bao: phn tch vai tr ca cc thnh phn trong cng
thc? Nu cch pha ch v cch s dng dch bao ny bao vin?
1. CT 1:
HPMC 2910, USP, 15 cps
4%
Propylen glycol
1,2 %
Ethanol
45 %
Methylen clorid
v
100 %
2. CT2:
Eudragit E100
30 g
Talc
42 g
Magnesi stearat
6g
Titan dioxyd
18 g
Amaranth E 123
1g
PEG 6000
6g
Tween 80
2g
Nc
200 g
Isopropanol
700 g
Aceton
480 g
3. CT 3:
Eudragit L 100
30 g
Dibuthyl phtalat
3g
Talc
42 g
Magnesi stearat
6g
Yellow lake E 104
18 g
PEG 6000
6g
Isopropanol
900 g
Nc
12 g
Aceton
480 g
4. CT 4:
CAP
12 %
Propylen glycol
3%
Sorbitan monooleat
1%
Ethanol
45 %
Aceton
v
100 %
5. CT 5:
Cng thc Aquacoat:
Tng lng cht rn
29 32 %
Ethylcellulose
24,5 29,5 %
Natri lauryl sulfat
0,9 1,7 %

Alcol cetylic
1,7 3,3 %
pH
4,0 7,0
nht
150 cP
Kim loi nng
10 ppm
Tng s vi khun hiu kh
100 cfu/g
Tng s nm men v mc
20 cfu/g
S dng Aquacoat bao vin:
Aquacoat
450,00 g
Dibuthyl sebacat
33,48 g
Dung dch HPMC E-5 14%
132,71 g
Nc
149,97 g
6. CT 6:
Eudragit L 100-55
12,5 %
PEG 6000
1,0 %
Triethyl citrat
1,2 %
Talc
3,1 %
Titan dioxyd
2,1 %
Nc
79,9 %
Natri hydroxyd
0,2 %
7. CT7:
Cellulose acetat phthalat
6,00 %
Propylen glycol
1,86 %
Sorbitan monooleat (Span 80)
0,66 %
Du thu du (khng mi)
0,12 %
FD&C Blue Dye No.1
0,85%
FD&C Yellow Dye No. 5 lake
3,11%
Titan dioxyd
5,33%
Methylen clorid
21,58 %
Aceton
va
100 %
8. CT8:
Hydroxy propyl methyl cellulose 2910 (15 cps)
4,5%
Hydroxy propyl cellulose
0,5%
Titan dioxyd
2%
Propylen glycol
2%
Ethanol
45%
Methylen clorid
v 100%

Mt s phng php bao c bit:

- Bao vin bng cch dp.
- Bao tnh in.
- Bao bng cch nhng.
- Bao film chn khng.
III. TIU CHUN CHT LNG VIN NN
Tiu chun v phng php nh gi: xem SGK, DVN IV, USP 35, BP 2012.
Trong cc tiu chun trn: tiu chun no lin quan n sinh kh dng, tiu chun
no lin quan n n nh ca vin nn?
IV. CC YU T NH HNG N SINH KH DNG CA VIN NN
1. nh hng ca ng dng - cch dng

c im hp thu thuc qua ng tiu ho? Vai tr ca cc yu t: thi gian

lu thuc, pH, h men, thc n, nim mc hp thu, h mch.
- V tr gii phng v hp thu dc cht ca tng loi vin nn?
2. nh hng ca vic xy dng cng thc
3. nh hng ca phng php - quy trnh dp vin
- p dng: cc bin php lm tng sinh kh dng ca vin?
X l tnh hung: Vin nn paracetamol khng t ch tiu ho tan (SKD in
vitro). Nu cc nguyn nhn v bin php khc phc.
V. MT S TH D V VIN NN
Phn tch c im, vai tr ca cc thnh phn trong cng thc. Trnh by phng
php bo ch, cng dng, cch dng ca nhng vin nn ny.
1. Vin nn aminophylin
Aminophylin
100 mg
Tricalci phosphat
50 mg
Pregelatinized starch
15 mg
Nc
v
Talc
30 mg
Du khong nh
2 mg
2. Vin nn propoxyphen napsylat - acetaminophen (APAP) (100/650 mg)
90% Pregranulated APAP
722,19 mg (ht:90% paracetamol)
Propoxyphen napsylat
100,00 mg
Avicel PH 102
34,77 mg
Ac Di Sol
8,70 mg
Cab-O-Sil
1,30 mg
Magnesi stearat
3,04 mg
3. Vin nn aspirin - cafein
Aspirin
384,00 mg
Cafein
15,84 mg
Avicel PH 102
48,00 mg
Tinh bt
28,56 mg
Acid stearic
3,60 mg
4. Vin nn allopurinol
Allopurinol
300,00 mg
Emcompress
200,00 mg
Explotab
20,50 mg
Talc
10,00 mg
Cab-O-Sil
2,50 mg
Magnesi stearat
5,00 mg
5. Vin nn omeprazol
Omeprazol
10,00 mg
Calci glycerophosphat
175,00 mg
Calci lactat
175,00 mg
Natri bicarbonat
250,00 mg
Polyethylen glycol 6000
20,00 mg
Natri croscarmellose
12,00 mg
Peppermint flavor
3,00 mg
Magnesi silicat
1,00 mg
Magnesi stearat
1,00 mg
6. Vin nn simvastatin
Simvastatin
10,00 mg

Lactose monohydrat
55,23 mg
Pregelatinized starch (Starch 1500)
15,00 mg
Butyl hydroxy anisol
0,02 mg
Acid ascorbic
2,50 mg
Acid citric
1,25 mg
Cellulose vi tinh th (Avicel PH 102)
15,00 mg
Magnesi stearat
0,60 mg
Colloidal silicon dioxide (Aerosil 200)
0,30 mg
Nc tinh khit
12,00 mg
Ethanol tuyt i
5,00 mg
7. Vin nn amoxicilin trihydrat v kali clavulanat
Amoxicilin trihydrat (compacted)
587,50 mg 500 mg amoxicilin khan
Hn hp kali clavilanat v Avicel (1:1) 305,00 mg 125,00 mg clavulanat
Sodium starch glycolate
25,00 mg
Aerosil 200
30,00 mg
Sodium carmellose
10,00 mg
Talc
10,00 mg
Magnesi stearat
5,00 mg
Bao vin bng dung dch HPMC trong dung mi hu c.
8. Vin nn acid ascorbic
Acid ascorbic
250 mg
Explotab
15 mg
Dung dch EC (50 cps) 10% trong ethanol v ( 4 mg)
Calci silicat
10 mg
9. Vin nn hydroclorothiazid
Hydroclorothiazid
50 mg
Lactose monohydrat
422 mg
Kollidon 90 F
8 mg
Isopropanol
0,038 ml
Kollidon CL
15 mg
Magnesi stearat
2 mg
10. Vin nn meprobamat
Meprobamat
400,0 mg
Tinh bt ng
100,0 mg
PVP K-25
15,0 mg
PEG 400
4,5 mg
Isopropanol
va
Talc
2,0 mg
Aerosil 200
0,2 mg
Calcium arachinat
0,3 mg
11. Vin si paracetamol
Paracetamol, KTTP < 300 m
500 mg
Natri hydrocarbonat
500 mg
Acid tartaric, bt mn
430 mg
Dextrose
200 mg
Cht thm
va
PVP K30
20 mg
Isopropanol
0,1 ml
Polyethylen glycol 6000, bt mn
60 mg
12. Vin nn amoxiclin kali clavulanat

Amoxicilin trihydrat
Hn hp kali clavulanat : Avicel (1:1)

587,5 mg
( 500,0 mg amoxicilin khan)
305,0 mg
( 125,0 mg acid clavulanic)
25,0 mg
30,0 mg
10,0 mg
10,0 mg
5,0 mg

Sodium starch glycolate

Aerosil 200
Croscarmellose sodium
Talc
Magnesi stearat
13. Vin nn cimetidin
Cimetidin
200,00 mg
Cellulose vi tinh th
48,89 mg
PVP K-30
6,00 mg
Natri lauryl sulfat
0,40 mg
Dispersed blue E123
0,26 mg
St oxyd vng
0,26 mg
Tinh bt ng
13,11 mg
Sodium starch glycolate
9,44 mg
Magnesi stearat
1,40 mg
Nc tinh khit
va
14. Vin nhai nhm hydroxyd magnesi hydroxyd
Nhm hydroxyd
200 mg
Magnesi hydroxyd
200 mg
Lactose monohydrat
100 mg
PEG 6000 (bt mn)
60 mg
Aerosil 200
12 mg
Saccarose (tinh th)
315 mg
Sorbitol (tinh th)
100 mg
Talc
6 mg
Magnesi stearat
6 mg
PVP K-30
30 mg
Nc tinh khit
va
15. Vin nn prednisolon
Prednisolon (bt siu mn)
10,0 mg
Cellulose vi tinh th (Avicel PH102)
49,5 mg
Natri croscarmellose (Ac-Di-Sol)
5,0 mg
Sodium starch glycolate (Primojel)
7,5 mg
Lactose (phun sy)
105,0 mg
Tinh bt ng
25,0 mg
Magnesi stearat
1,5 mg
Silic dioxyd dng keo khan (Aerosil 200)
1,0 mg
16. Vin nn atorvastatin
Atorvastatin calci trihydrat
11,0 mg
(tng ng vi 10,0 mg atorvastatin)
Calci carbonat
36,0 mg
Lactose monohydrat
65,0 mg
Cellulose vi tinh th (Avicel PH102)
30,0 mg
PVP K-30
3,0 mg
Polysorbat 80 (Tween 80)
0,4 mg
Natri croscarmellose (Ac-Di-Sol)
4,0 mg

Magnesi stearat
Nc tinh khit
VI. MT S VIN NN C BIT
T c SGK

0,6 mg
va

PHN II. VIN TRN

T c SGK