Dc chnh quy 2012

CU HI N TP HA DC
I. THUC TC NG LN H TKTV
1. THUC TC NG LN H GC
1.

ba cht trn l thuc cng giao cm thuc:

A. nhm imidazole, tc ng trn th th alpha
B. nhm imidazole, tc ng chn lc trn th th alpha 1
C. nhm phenylethylamine, tc ng trn th th alpha
D. nhm phenylethylamine, tc ng chn lc trn th th alpha1
2.

Cc cht trn thuc nhm:

A. cng giao cm
B. cng i giao cm
C. lit giao cm
D. lit i giao cm

3. Trong phn ng vi beta-naphtoquinon-4-natri sulfonate:

A. phenylephrine dng tnh v l amin bc 1, metaraminol m tnh v l amin bc 2
B. phenylephrine dng tnh v l amin bc 2, metaraminol m tnh v l amin bc 1
C. phenylephrine m tnh v l amin bc 1, metaraminol dng tnh v l amin bc 2
D. phenylephrine m tnh v l amin bc 2, metaraminol dng tnh v l amin bc 1

4.

chn ng v cht c cng thc trn:

A. bn vi MAO, bn vi COMT, c phn ng to phc vi CuSO4
B. bn vi MAO, khng bn vi COMT, c phn ng to phc vi CuSO4
C. bn vi MAO, bn vi COMT, khng c phn ng to phc vi CuSO4
D. khng bn vi MAO, khng bn vi COMT,khng c phn ng to phc vi CuSO4
5.

(1) (2) (3)

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Cng thc no c tc dng chn lc trn beta 2:
A. 1 v 3
B. 2
C. 2 v 3
D. 1 v 2
E. 3
6.

Tp no cn kim i vi c 3 cht trn:

A. aminoceton
B. catechol
C. catecholamine
D. ethanol
7. Tp quan trng cn kim i vi dopamine?
A. 4-O-methyldopamine
B. 3-O-methyldopamine
C. 3,4-dimethoxidopamine
D. 3,5-dimethoxidopamine
8. Cu no sau y l ng v tc dng ca ephedrine v pseudoephedrine:
A. ephedrine c tc dng trc tip, pseudoephedrine c tc ng gin tip kch thch h giao cm
B. ephedrine c tc dng gin tip, pseudoephedrine c tc ng trc tip kch thch h giao cm
C. ephedrine c tc dng trc tip v gin tip, pseudoephedrine c tc ng gin tip kch thch h
giao cm
D. c ephedrine v pseudoephedrine u ch c tc ng gin tip ln h giao cm
9. C th phn bit naphazoline v xylometazoline bng:
A. phn ng to phc vi CuSO4
B. phn ng Pesez
C.th pH
D. phn ng pht hunh quang

P N TRC NGHIM:
1-A 4-A 7-A
2-A 5-D 8-C
3-D 6-A 9-D

B. CU HI NGN:
1. t cng thc dopamine
v cng thc L-dopa?

2. t cng thc bambuterol

n l tin dc ca cht no? v cng thc?

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3. cho cng thc terbutaline

ngh 1 phng php nh lng?

4. cho cng thc phenylephrine

v cng thc ca phc cht vi CuSO4.

5. cho cng thc ca dipivefrine.

l tin dc ca cht no? V cng thc?

6. cho cng thc salbutamol

V cng thc pirbuterol?

P N CU HI NGN:

1.

2. Tin dc ca terbutaline:
3. Chun vi acid HCl. Sau chun HCl d bng NaOH ( phng php tha tr)
4.

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5. tin dc ca adrenaline:
6.

II. THUC TC NG TRN H DGC

1. Cho cc cng thc sau, nhn nh no sau y l NG?
O CH3 O CH3 O H
+ + +
N (CH3)3 N (CH3)3 N (CH3)3
H3C O H2N O H2N O
(1) (2) (3)
A. C ba cht u tc ng chn lc trn th th Muscarin.
B. Ch (2) v (3) cho tc ng chn lc trn th th Muscarin.
C. Ch (1) v (2) cho tc ng chn lc trn th th Muscarin.
D. Ch c (3) tc ng chn lc trn th th Muscarin.
2. Cu no sau y v Bethanechol l KHNG NG?
A. L cht ch vn Muscarinic mnh.
B. Khng bn, ch s dng dng thuc nh mt tr glaucom.
C. Khng b mt tc dng khi sy autoclave 120oC/ 20 pht.
D. Nu tim, ch tim di da, khng c tim IV hoc IM.
3. Cu no sau y v Pilocarpin l KHNG NG?
A. ng phn ha to isopilocarpin vn cn tc ng.
B. D b thy phn to acid pilocarpic mt tc ng.
C. Khng bn, nh mt tr glaucom phi dng nhiu ln trong ngy.
D. nh lng bng phng php mi trng khan.
4. Cho cc cng thc sau, cht no c th s dng iu tr Alzheimer?
CH3 CH3 CH3
+
H3C O N CH3 N O NH
N H3C CH3
CH3
CH3 O O

(1) (2)
CH3
H3C + O N
N CH3
O

(3)
A. (2) v (3).
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B. (3).
C. (1).
D. (1) v (3).
5. C ch c ch acetylcholinesterase khng thun nghch ca Malathion?
A. Acetyl ha acid amin serin ca acetylcholinesterase.
B. Carbamoyl ha acid amin serin ca acetylcholinesterase.
C. Phosphoryl ha acid amin serin ca acetylcholinesterase.
D. Metyl ha acid amin serin ca acetylcholinesterase.
6. Cho cng thc chung cht i vn Muscarinic tng hp:
R3
R2 X (CH2)n N
R1

Nhn nh no sau y l KHNG NG?

A. X phi l ni ester mi c tc ng.
B. R3 l -OH hoc -CH2OH cho tc ng tt hn.
C. R1 v R2 l vng thm hoc vng no.
D. Cc cht dng iu tr Parkinson c N bc 3.
7. Cu no sau y v Tubocurarin l KHNG NG?
A. Cho phn ng vi FeCl3.
B. C hai chc amin lin quan ti tc ng.
C. Cho phn ng vi thuc th ca alkaloid.
D. Tc ng ch vn trn th th Nicotinic.
8. Thuc no sau y c th dng cho bnh nhn b bnh gan v thn?
A. Pancuronium.
B. Atracurium.
C. Vecuronium.
D. Pipecuronium.
9. Pht biu no sau y v Succinylcholin l NG?
A. Cht i ch vn trn th th Nicotinic.
B. Bn trong dung dch.
C. Thi gian tc ng di.
D. Khng b chuyn ha bi acetylcholinesterase synap.
II. TR LI NGN
1. K tn cc tp lin quan ca pilocarpin cn kim theo Dc in Anh 2007.
2. Cho cng thc Pilocarpin, hy v cng thc isopilocarpic.

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H3CH 2C CH3
N
O
O N

3. Hy ngh mt phng php nh lng pilocarpin hydroclorid.

4. K tn 5 cht khng acetylcholinesterase dng trong iu tr Alzheimer.
5. Cho cng thc Atropin, hy v cng thc apoatropin.

6. Cho quy trnh iu ch Pyridostigmin bromid, hy v tp lin quan cn kim nghim.

O
N N N
CH3 O CH3Br O
+ Cl N CH3 CH3
OH O N O N
CH3
CH3 CH3

III.
P N
Trc nghim
1.C 2.B 3.A 4.C 5.C 6.A 7.D 8.B 9.D
Tr li ngn
1. Isopilocarpin, acid pilocarpic, acid isopilocarpic.
2.
H3CH 2C CH3
H
N
O
OH N
OH

3. nh lng trong mi trng khan

hoc nh lng acid - base gc HCl.
4. Rivastigmin, Galanthamin, Donepezil, Tacrin, Huperzin - A.

5.

6.
CH3
+
N

OH

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III. THUC IU TR DAU THT NGC
1/ C th iu ch quinidin bng cch no
A ng phn ha
B methyl ha
C hyrdo ha
D demethyl ha
2/ Quinidin sulfat c PH bao nhiu
A 5-5,8
B 2-2,8
C 3-3,8
D 6-6,8
3/ Quinidin bisulfat c PH bao nhiu
A 2,6-3,6
B 3,6-4,6
C 4,6-5,6
D 5,6-7,6
4/ Cch nhanh chng phn bit quinidin bisulfat v quinidin sulfat
A Th PH
B IR
C HPLC
D GC
5/ T procain thay nhm chc no thnh procanamid c T1/2 di
A amid
B carboxylic
C methyl
D ete
6/ Tc dng ph b Lupus ban ca procanamid thng qui cho nhm no
A Amin thm
B amid
C Amin bc 3
D nhnh alkyl
7/ Nhm no gip Tocaninide chuyn ha chm gip sinh kh dng ng ung tuyt ho
A alpha methyl
B amid
C amin bc 1
D vng thm
Tr li ngn
1/ T cu trc quinine v cu trc quinidin

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TL

2/ T cu trc procain v cu trc procanamid

TL

3/ T cu trc procanamid hy nu 1 phng php nh lng ( khng dng HPLC)

TL Php th nitro
4/ Tn ng ca nitroglycerin l g?
TL Glycerintrinitrat
5/ Da v cng thc isosorbid v 2 tp

TL

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IV. VITAMIN
1. Cht c cu trc khng vitamin K, ngoi tr:
A. Phenylindanedion
B. Dicoumarin
C. Monocoumarin
D. Indan-dion
E. Antraquinon

2. Vitamin A l tn chung ca mt s cht c cu trc ha hc v hot tnh tng t nhau, ngoi tr:
A. Arotinoid
B. 3-dehydroretinol
C. Chromanoid
D. Retinol
E. Acid retinoid

3. Phn ng phn bit pyridoxol vi pyridoxal v pyridoxamin:

A. Tc dng vi 2,6-dicloroquinon clorimid
B. Tc dng acid boric to ester vng bn
C. To ta vi H2SO4
D. Tc dng vi mui diazoni/ZnCl2
E. Tc dng FeCl3 to mui phc c mu

4. Vitamin C l dn xut ca nhn

A. Furan
B. Pyrol
C. Thiophen
D. Benzimidazol
E. Thiazol

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5. Cu trc ca acid folic bao gm cc phn, ngoi tr:
A. Acid glutamic
B. Acid pteroic
C. Acid p-aminobenzoic
D. Lin kt peptid
E. Acid aspartic

6. Tretinoin v alitretinoin l dn cht ca vitamin A ng dng trong iu tr ung th tc ng trn th

th retinoid. Th th retinoid nm ti v tr:
A. Bn trong t bo
B. T bo cht
C. Bn trong nhn
D. Khong gian bo
E. Mng t bo

7. Tc dng ca vitamin D: ngoi s dng trong iu tr long xng, cn c s dng cho cc ch

nh sau, ngoi tr:
A. Cm cm
B. Tng cng sc khng
C. Vim gan B v C
D. Ci xng tr em

8. Liu s dng calci v vitamin D c khuyn co phng nga v iu tr long xng:

A. 1200mg calci v 800UI vitamin D
B. 600mg calci v 800UI vitamin D
C. 1000mg calci v 800UI vitamin D
D. 1600mg calci v 400UI vitamin D

9. Khi ung lu di, du parafin ngn cn s hp thu ca:

A. Vitamin B9
B. Vitamin E
C. Vitamin C
D. vitaminB1

10. c th dng phn ng to thiocrom nh lng vitamin B1 khng:

A. c, bng cch o mt quang
B. c , bng cch o cng pht quang
C. c, bng cch o mu
D. khng c, v thiocrom khng bn

11. vitamin A dng acid c ch nh trong trng hp:

A. kh mt qung g
B. da kh trc vy
C. c thy tinh th
D. mn trng c

12. s nguyn t C mch chnh ca vitamin E cho hot tnh mnh nht:
A. 5
B. 9
C. 13
D. 17

13. Acid ascorbic c th tc dng c vi cc thuc th no sau y

A. Fehling
B. Bc nitrat
C. 2,6-diclorophenol indophenol
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D. Tt c

14. Cu no sau y sai:

A. Tp quan trng nht ca vitamin C l acid oxalic
B. Thiocrom tan c trong nc
C. nh lng vitamin C bng phng php Iod
D. Mu ca cc retinoid do h lin hp trong cu trc quyt nh

15. Cu trc cn bn ca retinoid thn du bao gm:

16. Dng s dng ca vitamin D cho bnh nhn suy gan?
17. Phng php nh lng vitamin E?
18. Phn ng ca vitamin B6 vi 2,6-dicloroquinon clorimid cho mu g?
19. Vitamin no c s dng chun ha my UV 360nm?
20. phng php nh lng vitamin C?
P N:
1 2 3 4 5 6 7
E C D A E C C
8 9 10 11 12 13 14
A B B B C D B
15. mt vng tn cng, mt nhnh polyen, mt nhm tn cng phn cc
16. calcifediol
17. sc k kh
18. xanh
19. B12
20. Phng php iod

V. THUC GIM AU H ST KHNG VIM TR GOUT

1. NSAIDs c tc dng c ch chn lc COX-2 mnh nht:

C.
2. A.

D.
B.
3.

4. Cng thc chng kt tp tiu cu sau y l ca cht no:

A. Ticlopidin
B. Dipyridamol
C. Flurbiprofen
D. Acid acetyl salicylic
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5. Nng sut quay cc l tiu chun quan trng trong kim nghim
A. Naproxen
B. Diflunisal
C. Indomethacin
D. Nimesulid
6. Propacetamol [4-(acetylamino)phenyl(diethylamino)acetat] l cht:
A. Lng, kh tan trong nc
B. Rn, kh tan trong nc
C. Lng, d tan trong nc
D. Rn, d tan trong nc

7. Cng thc cht chng kt tp tiu cu sau y l ca cht :

A. Flubiprofen
B. Ticlodipin
C. Dipyridamol
D. Aspirin
8. Hai tp quan trng c kim trong chuyn lun Proparacetamol hydroclorid :
A. Paracetamol v HCL
B. Paracetamol v 4-aminophenol
C. 4-aminophenol v N,N-diethyl glycin
D 4-aminophenol v HCl
9. Thuc th c s dng nh tnh acetat hoc nhm acetyl (dng nh tnh acetaminophen) :
A. FeCl3
B. NaNO2/HCl
C. Lanthan nitrat/I2/NH4OH
D. Kalidicromat

10. Dn cht sau l cu trc ca NSAIDs nhm:

A. coxibs vi tc dng khng vim mnh nht khi nhm NH ni vi d vng thm
B. sulides vi tc dng khng vim mnh nht khi nhm NH ni vi vng thm
C. oxicam vi tc dng khng vim mnh nht khi nhm NH ni vi d vng thm
D. oxicam vi tc dng khng vim mnh nht khi nhm NH ni vi CH3
11. Cho bit tn ca mt dn cht acid salicylic b mt tnh khng vim sau khi amid ha ? (salicylamid)

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12. V cng thc proparacetamol?

13. ngh mt thuc th to phn ng mu nh tnh indomethacin?

To phc hng tm vi FeCl3 sau khi phn ng vi hydroxylamin hoc phn ng vi
p.dimethylamino benzaldehyd (PDAB) cho ta mu xanh.
14. Vit phng trnh phn ng biu din vic nh lng aspirin da vo nhm chc ester v acid:
Aspirin + 2NaOH -> HO-C6H4-COONa + CH3COONa + H2O
15. Aspirin c tc dng c ch kt tp tiu cu l do c ch :
A. c ch thnh lp acid arachidonic
B. c ch enzym lipooxigenase nn khng to c prostaglandin
C. c ch enzym cyclooxigenase nn khng to c prostaglandin
D. c ch prostaglandin
16. ngh mt phng php chun nh lng nimesulid (ghi r dung dch chun ) ?
Phng php acid-base : dng chun NaOH 0,1M
17. Gii thch v sao a s cc cht NSAIDs u c tnh acid:
Do c c ch c ch cnh tranh vi acid arachidonic
18. Vit cng thc tng qut ca cc NSAIDs thuc nhm acid aryl alkaloid:
Ar-CH-( R )- COOH
19. Phng php nh lng Diclofenac natri:
A. Chun bng dd HCl, ch th phenolptalein
B. Chun mi trng khan, dd chun methylat natri
C. Chun mi trng khan, dd chun acid percloric
D. Chun bng dd KOH, dd chun phenolptalein
20. Dng hot tnh ca aspirin trong c th l:
Acid salicylic
21. Paracetamol l cht chuyn ha ca khi vo trong c th
Phenacetin
22. Nimesulid c th nh lng bng phng php chun :
A. Mi trng nc vi dd chun l HCl
B. Mi trng nc vi dd chun l NaOH
C. Mi trng khan vi dd chun l HClO3
D. Mi trng khan vi dd chun l HCl
E. Mi trng nc vi dd chun l methylat natri
23. Tp lin quan trong kim nghim colchicin c ngun gc t s tip xc vi nh sng l:
A. 3-O.demethyl colchicin
B. Beta-Lumicolchicin
C. Colchicosid
D. N-deacetyl-N-formycolchicin
E. Colchicein

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24. Phng php c th s dng nh lng Allopurinol lactam?
(i): Quang ph UV
(ii): Mi trng khan/dd chun l acid percloric
(iii) : Mi trng khan/dd chun l tetrabutylammodium hydroxid
A. (i) v (ii)
B. (i)
C. (ii)
D. (iii)
E. (i) v (iii)
25. Meloxicam c th nh lng bng phng php
A. Mi trng nc vi dd chun l HCl
B. Mi trng nc vi dd chun l NaOH
C. Mi trng khan vi dd chun l HClO3
D. Mi trng khan vi dd chun l HCl
E. Mi trng nc vi dd chun l methylat natri
26. Dn cht ca para cetamol c th dng ng tim l :
A. 4-acetamidophenyl diethylaminoacetat v propacetamol HCl
B. Acetaminophen
C. Propacetamol HCl
D. 4-acetamidophenyl diethylaminoacetat
E. Propacetamol

25. ngh mt phn ng mu dng nh tnh nimesulid :

Phn ng diazo ha

VI. THUC TR LOT D DY T TRNG

1.Thuc c ch bm proton l dn xut ca
A. Benzofuran
B. Benzimidazol
C. Benzylisoqinon
D. Nitrofuran
E. Cyclohexanon
2.C ch tc ng ca omeprazol
A.c ch lung Na+
B. c ch dng Ca2+
C. c ch H+/K+ ATPase
D. Gn vo nhm SH
E. C v D ng
3.Tc dng ph ca nhm hydorxyd
A. To bn
B. Mt Ca2+ ca c th
C. Mt PO43- ca c th
D. A,C ng
E. A, B ng
4. Misoprostol c tc dng bo v nim mc d dy do:
A. L prostaglandin thin nhin nn khng gy d ng
B. Kch thch to cht nhy
C. Gy gim co tht nn mau lnh so
D. Trung ha acid d
E. Gia tng s ti mu
5.Sp xp th t gim dn v mt tng tc thuc ca cimetindin (I), ranitidin (II), famotidin (III)
A. I > II> III
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B. I> III> II
C. II> I > III
D. II> III > I
E. III> II >I
6. Nhn no sau y l thnh phn trong phn t cimetidin
A.Pyridin
B. Pyrimidin
C. Imidazol
D. Furan
E. Thiazolin
7.Da vo cu trc chung ca cc thuc i khng ti th th H2, s hin din ca S trong mch
cacbon c tc dng
A. Tng hot tnh ca phn t
B. Tng tnh tm qua mng c th ung
C. Lm chm s o thi.
D. Lm gim c tnh trn gan
E. Lm gim c tnh trn thn
8.Thuc trung ha acid no sau y c hp thu vo mu hn 20%
A. NaHCO3
B. CaCO3
C. Al(OH)3
D. AlPO4
E. Mg(OH)2
9.Omeprazol c tc ng
A. Ngay sau khi tip xc vi nim mc d dy lc ung.
B. Sau khi c chuyn ha gan thnh dng c hot tnh.
C. Khi lin kt vi protein huyt tng.
D. Sau khi c phng thch khi protein huyt tng
E. Sau khi c tit vo vng ng ca t bo vin
10.Phng php nh lng Omeprazol
A. Phng php Acid base
B. Chun Na EDTA
C. Mi trng khan
D. Khng no ng
II/ Cu hi ngn
1. Omeprazol c ch men H+/K+ ATPase l men ca t boS c ch do tc ng vo nhm .
ca enzym.
2. Omeprazol l ng phn c dng .
3. Thuc i khng ti th th H2 Histamin c 2 dng l v Trong dng c nh ln th th
H1
4. Sucralfat nn ung vo lc no?
5. Misoprostol thng gy nn gy tiu chy, hn ch cho ph n c thai
p n
1B 2C 3D 4B 5A 6C 7B 8A 9E 10A
Cu hi ngn
1. T bo vin SH
2. R
3. rng - gn - dng rng
4. D dy rng (trc ba n 1 gi hoc ban m)
5. Co tht c trn

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VII. THUC THAY I CHC NNG VN NG NG TIU HA, THNG
MT LI MT, LM TAN SI MT
*Thuc chng hi lu d dy thc qun:
1.Thuc t qua hng ro mu no, c i lc trn thu th dopamin ngoi bin, tng tc lm rng d dy
c tc ng chng hi lu:
A. Cisaprid
B. Domperidon (tng tc lm rng d dy, ngoi ra cn c tc dng chng nn)
C. Phosphalugel
D. Alginat (d thp, s nc nn khng thm dch v, trnh tn hi thnh thc qun)
E. Maalox
2. Phng php nh lng Domperidon
A. Chun trong MT nc (cht ch NaOH)
B. Chun trong MT khan (cht ch HclO4) (c nhiu N mang tnh baso yu)
C. Chun bng amonicerisulfat
D. Phng php iodid iodat
E. Chun trong MT khan (Methylat Na)
3. Tc dng ph ca domperidon:
A. Ri lon ngoi thp (him: 1 phn triu)
B. Xut huyt
C. Thng d dy
D. Xon nh
E. Co git
4. C ch chung ca thuc chng nn
A. Tng vn ng ng tiu ha
B. To thnh lp gel nhy bo v ng tiu ha i vi acid
C. Trung ha acid d dy
D. c ch ng truyn vo tr tm nn thng qua vic c ch cc cht trung gian ha hc (Dopamin,
Serotonin, Histamin, Acetylcholin)
E. Kch thch ngoi bin

*Thuc chng nn
5. Chn cu tr li cho tng ng:
Cht trung gian ha hc Thuc chng nn
1.i khng th th dopamin (D2) Lm A. dimenhydranat (nausicalm),
tng tnh vn ng d dy diphenhydramin (nautamine)
2.i khng th th 5-HT3 ca serotonin B. Cisapride
c ch ng truyn vo
3.Khng Histamin (nhm gy bun ng) C. Ondasetron, Granisetron, Tropisetron
4.Tng phng thch Ach(ko tc ng ln D. Scopolamin (TDP: glocom gc hp)
M, N nn ko tit d v) Tng p c vng
di thc qun, y cc cht xung d dy
5.Khng Cholinergic E.Domperidon, Metoclopramid, Alizaprid
1.E, 2.C, 3.A, 4.B, 5.D

6. Nguyn liu u dng iu ch Metoclopramid:

A. 2-methyl-4-nitrobenzoyl clorid
B. 2-metoxy-4-nitrobenzoyl clorid
C. 4-metoxy-2-nitrobenzyl clorid
D. 4-metoxy-2-nitrobenzoyl clorid
E. 2-metoxy-4-amonibenzoyl clorid
7. Phng php nh lng metoclopramid
A. Chun trong MT nc (cht ch NaOH)
B. Chun trong MT khan (cht ch HclO4) (c 3N mang tnh bazo)
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 Dc chnh quy 2012
C. Chun bng amonicerisulfat
D. Phng php iodid iodat
E. Chun trong MT khan (Methylat Na)
8. Ngoi ch nh chng nn, metoclopramid cn c ch nh
A. Chng hi lu d dy thc qun
B. Vim thc qun do hi lu
C. Cm tiu chy
D. A&B
E. B&C
9. Tc dng ph ca metoclopramid
A. Bun ng
B. Ri lon ni tit (tng prolactin huyt)
C. Methemoglobin huyt thun nghch tr s sinh
D. Ngoi thp
E. A,B &C
*Thuc gy nn:
10. Thuc c tc dng gy nn
A. Apomorphin (ging dopamin, ko c td gim au, k thch D1 mnh, D2 yu, t ngn)
B. Domperidon (chng nn)
C. CuSO4 (0.3%), ZnSO4 (0.3-1%) (kch thch ngoi bin)
D. A &C
E. A,B,C
11. Thuc dng gii c Apomorphin:
A. Naloxon
B. Carbenoxolol
C.Allopurinol
D.Barbituric
E.Strychnin
12. Tc dng ph ca Apomorphin:
A. Gy nghin
B. Hi chng ngoi thp
C. Tng huyt p
D. Gy suy h hp
E. Glocom

* Thuc nhun trng thuc x

13. Cht no gy kch thch tit hormon cholecystokinin lm tng nhu ng rut
A. MgSO4
B. Du thu du
C. Du Olive
D. A&B
E. Tt c u ng
14. MgSO4 c tc dng nhun trng do:
A. Kch ng rut
B. Lm trn thnh rut
C. Thm thu
D. Lm sinh hi rut
E. To iu kin cho vi khun pht trin
15. Bisarcodyl c tc dng nhun trng do:
A. Kch ng rut (tng nhu ng, tng tit dch khi tip xc trc tip vs rut)
B. Lm trn thnh rut
C. Thm thu
D. Lm sinh hi rut
E. To iu kin cho vi khun pht trin
16. Ngoi ch nh chnh lm thuc nhun trng, lactulose cn c dng trong:
17
 Dc chnh quy 2012
A. Bnh no gan mn tnh (do lm gim s hp thu amoniac vo mu)
B. Nghn rut
C. Vim rut gi
D. Suy gan
E. T c u ng
17. Du vaselin t dng lm thuc nhun trng do:
A. Mi v kh chu
B. D b ht vo kh qun
C. Ngn cn hp thu vitamin tan trong du
D. A&C
D. A,B&C
18. Cc tnh cht sau l ca du thu du:
A. Triglicerid ca acid ricinoleic
B. Thy phn thnh glycerol v acid ricinoleic c hot tnh
E.Tt c u ng
19. Chn cu cho tng ng:
C ch Thuc nhun trng
1.Thm thu dng ng A.Du thu du
2.Thm thu dng mui B.NaHCO3+Kali Bitartrat,
Glycerin+Manitol (nhun trg do to hi)
Sorbitol, gelatin+glicerin (lm nhn, lng
phn, px bi xut phn)
3.Dng du nhn C.MgSO4, NaSO4,
4.Cht x D.Anthraquinon
5.Kch thch rut non E.Parafin, du da, olive liu cao
6.Kch thch rut gi G.Sorbitol, Lactulose
7.ng trc trng H.Cm, gm sterculia
1.G, 2.C, 3.E, 4.H, 5.A, 6.D, 7.B
*Thuc cha tiu chy:
20. Cho bit tc dng ca cht c cng thc sau:

A.Tr to bn
B. Tr tiu chy (loperamid)
C. Tr si mt
D. Tr bnh no gan
E. Tr hi lu d dy thc qun
21. Thnh phn cng thc ca DIARSED gm:
A. Diphenoxylat + atropin
B. Loperamid + atropin
C. Diphenoxylat + acetylcholin
D. Loperamid + acetylcholin
E. Cao Opium + atropin

18
 Dc chnh quy 2012

22. Chn cu cho tng ng:

Thuc tr tiu chy C ch tc ng
1.NaCl KCl Glucose (Oresol) A.Hp ph c t
2.Acetorphan B.Khng khun ng rut
3.Loperamid, diphenoxilat C.Cung cp vi khun
4.Than hot, CaCO3 D.Chng tit nc, cht in gii (c ch
enkephalinase)
5.Cht nhy, pectin E.B nc
6.Bacillus subtilis, Saccharomyces F.Khng vim ng rut
Boulardii
7.KS: Hydroxyquinolein, nitrofuran G.Gim nhu ng rut
Sulfamid: Sulfaguanidin
8.5-ASA (acid 5-aminosalicylic) H.Bo v nim mc
1.E, 2.D, 3.G, 4.A, 5.H, 6.C, 7.B, 8.F

*Thuc li mt thuc thng mt lm tan si mt:

23. Chn cho tng ng:
Nhm thuc Tn thuc
1.Thuc li A.Triglycerid thin nhin(olive, a.oleic, ester)
D/xut hydroxyl: cyclovalon, sorbital
2.Thuc thng mt B.D/x ca a.cholanic: Acid ursodesoxycholic,
acid chenodesoxycholic.
3.Lm tan si mt C.Anethoitrithione, acid cinametic, albendol
1.C, 2.A, 3.B
24. Acid ursodeoxycholic lm tan si mt do:
A.To thun li cho s ha tan ca cholesterol trong mt
B. c ch sinh tng hp cholesterol
C. Gy co tht v tho sch ti mt
D. A v B
E. A,B v C
25. Cc tnh cht sau l ca thuc thng mt:
A. Gy co tht v tho sch ti mt
B. Kch thch tit cholecystokinin hay pancreatozinin t trng gy co tht v tng tit enzym tiu ha ca
ty
C.To thun li cho s ha tan ca cholesterol trong mt
D. c ch sinh tng hp cholesterol
E. A v B

Cu hi ngn:
1.Bisarcodyl c nh lng bng phng php (1).. Magie sulfat nh lng bng phng
php(2)..
2. Lactulose lm gim s hp thu amoniac vo mu bng cch(3)v (4)..
3. Hot cht trnh to bn c dng chung vi than hot khi hp ph cht c (5)
4. Lactulose trong rut phn hy thnh (6). v (7)
5. K tn hai tc dng ph ca nhm hydroxyd (8).. v (9)..
6. K tn hai hp cht thng phi hp vi Al(OH)3 trung ha acid dch v (10)..
7. Lactulose l sn phm isomer ha ca (11)
8. Sulcrafat mang nhiu nhm chc (12).. trong phn t nhng khng c kh nng trung ha acid dch
v
9. (13) dng cho bnh nhn trc khi chp hnh rut
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 Dc chnh quy 2012
10. Apomorphin l thuc gy nn c tc ng (14) khong (15)
Tr li:
(1) nh lng trong mi trng khan (cht c HclO4)
(2) Complexon
(3)Tng tiu th amoniac bi vi khun
(4)Chuyn NH3 thnh dng NH4+ khng hp thu v thi qua phn
(5)Sorbitol (ngoi ra sorbitol cn dng chung vi sulfonat polystyren trong trng hp tng Kali huyt)
(6) acid lactic (7) acid acetic
(8) to bn (9) mt PO4 3- ca c th
(10)Mg(OH)2 v CaCO3
(11) Lactose
(12) Al(OH)3
(13) Polyethylenglycol ng trng phi hp vi Na2SO4, Na2CO3, NaCl
(14) ngn (15) 45-90 pht

VIII. THUC DNG CHO MU v H TO MU

Cu 1: Acid folic kt hp vi st c khuyn dng:
A. Cho ph chun b c thai v 3 thng u thai k
B. Cho ph n c thai t tun l th 1 n 12 ca thai k
C. Cho ph n 3 thng u thai k
D. Cho ph n c thai t tun l th 13 ca thai k
Cu 2: Cng thc ca cht chng kt tp tiu cu sau y l cht no?

A. Ticlopidin
B. Dipyridamol
C. Flurbiprofen
D. Acid acetyl salicylic
Cu 3: Dng st t gp tc dng ph v t gy tng tc thuc thc n:
A. St gluconat
B. St protein succinylate
C. St fumarat
D. St glycin sulfat
Cu 4: Chn thuc c tc dng h triglycerid/mu v tng HDL tt nht:
A. Clofibrat
B. Atorvastatin
C. Rosuvastatin
D. Mui mt
Cu 5: Cc statin tc ng theo c ch:
A. To phc vi cholesterol v triglycerid
B. To phc vi acetylcholine esterase
C. To phc vi enzym glucose-6-phosphate-dehydrogenase
D. Cnh tranh v tr gn vi 6-hydroxymethyl glutanyl CoA reductase gan
Cu 6: C ch tc ng ca Clopidogrel:
A. Thay i cu trc glycoprotein tiu cu
B. c ch thnh lp thromboxan A2
C. c ch kt tp tiu cu
D. Ly gii huyt khi
Cu 7: Cu trc ca acid folic bao gm cc phn, ngoi tr:
A. Lin kt peptid
B. Acid p-anminobenzoic
20
 Dc chnh quy 2012
C. Acid glutamic
D. Pteroylaspartic
E. Acid phteroic
Cu 8: K tn 2 tp cht thng gp Simvastatin.
Cu 9: Phng php nh lng Vitamin K1 theo BP 2013 l:
A. Ph UV
B. IR
C. Sc k lng
D. Sc k lp mng
Cu 10: Phng php nh lng acid tranexamic theo BP 2013 l:
A. Mi trng khan: acid acetic khan, acid percloric, in th k
B. Mi trng khan: acid acetic khan, in th k
C. Mi trng khan: acid acetic khan, acid percloric
D. Mi trng khan: acid acetic khan
Cu 11: gii c cyanid c th dng vitamin B12 dng no?
A. Cyanocobalamin
B. Hydroxobalamin
C. C th dng c hai loi
D. Khng dng vitamin B12 gii c cyanid
Cu 12: Phng php nh lng Aprotinin theo BP 2013 l:
A. UV
B. IR
C. Sc k lng
D. o kh nng c ch enzym trypsin
Cu 13: Phng php nh tnh Dextran 70 theo BP 2013 l:
A. Nng sut quay cc
B. Ph IR
C. Khi lng trung bnh
D. C ba phng n trn u ng
Cu 14: Tc ng ca Ezetimib trong gim cholesterol mu l:
A. Gim tng hp VLDL gan
B. Gim hp thu cholesterol rut
C. To phc khng tan vi acid mt
D. C ba c ch trn
Cu 15: Trong cng thc ca Dextran:
A. Lin kt mch chnh l 1,4 glucosid, lin kt mch nhnh l 1,3 v 1,6.
B. Lin kt mch chnh l 1,6 glucosid, lin kt mch nhnh l 1,4.
C. Lin kt mch chnh l 1,6 glucosid, lin kt mch nhnh l 1,3 v 1,4.
D. Lin kt mch chnh l 1,4 glucosid, lin kt mch nhnh l 1,6.

1. A 7. D 12. D
2. D 8. Lovasratin v 13. D
3. B Epilovastatin 14. B
4. A 9. C 15. C
5. D 10. A
6. C 11. B

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 Dc chnh quy 2012
IX. THUC NG H HP
Phn 1. Trc nghim
1. Phn loi thuc ho theo cch tc dng, cu no sai?
a. c ch trung tm ho
b. Gim ngng ca cc vng phn x ngoi bin
c. Lm ngng tc ng lm bc pht cn ho
d. Loi b cht kch ng bng cch lm lng m, d di chuyn
2. Trung tm h hp gm
a. Ty, cu no, hnh no
b. Trung tm iu chnh/c ch h hp, trung tm ht vo/th ra
c. C lien sn ngoi/trong, c honh
d. C 3 cu trn u ng
3. Khi nng H+ v CO2 trong mu tng cao, vng no b kch thch gy thay i v tn s v
bin h hp?
a. Vng ht vo
b. Vng th ra
c. Vng c ch
d. Vng iu chnh
4. Cc loi kch thch gy ho, chn cu sai?
a. Lo lng, thi quen, vt l, kch thch hng
b. Vim ph qun, vim phi/ph qun
c. Bnh ti xoang, hng, d ng, suy tim
d. Thuc ACRIs
5. Chn cu ng
a. Ho mn ko di >8 tun
b. Ho mn do cc bnh nh lao, ung th, hen suyn, suy tim huyt, vim ph qun mn
c. Ho khan do d ng hay nhim khun
d. Ho c m do b kch thch
6. Thuc no thuc nhm c ch trung tm ho
a. codein, dextromerthorphan, noscarpin
b. terpin hydrat, natri benzoate
c. ambroxol, bromhexin, N- acetylcystein, carbocistein
d. benzonatat, menthol, lidocain, bupivacaine
7. Thuc lm ngng tc ng lm bc pht cn ho
a. du gi, gng, hng chanh
b. terpin hydrat, natri benzoate
c. ambroxol, bromhexin, N- acetylcystein, carbocistein
d. benzonatat, menthol, lidocain, bupivacaine
8. u khng phi nhm thuc tr ho
a. Khng sinh, khng vim
b. Khng histamine, chng d ng
c. Khng k sinh trng
d. Thuc cng giao cm
9. Chn cu ng
a. Chng ch nh codein cho tr di 2 tui
b. Khng khuyn cc dung codein cho tr 12-18 tui c vn v h hp
c. Salbutamol v Clenbuterol c php dung trong chn nui
d. C 3 cu u ng
10. Chn cu sai v dextromethorphan
a. c ch trung tm ho hnh ty
b. Khng c tnh gim au, khng gy quen thuc
c. Khng dung chung vi iMAO, quinine v cc thuc c ch thn kinh trung ng khc
d. Nhiu tc dng ph hn codein
11. Ch nh ca dextromethorphan no khng ng
a. Ho do kch ng, ht phi cht kch thch hay nhim khun,
22
 Dc chnh quy 2012
b. Ho do phn x sau khi phu thut,cm lnh thng thng
c. Ho mn tnh
d. Ho c m
12. Chn cu ng v acetylcystein
a. Hay xy ra tc dng ph trn tiu ha
b. Dng c cho ngi c tin s hen suyn
c. Khng nn dng chung vi tetracyclin, nitroglycerin
d. L 1 cht oxy ha
13. Chn cu sai
a. Hen thng xut hin bt u t phn ng d ng
b. Hen ph qun l bnh l vim mn tnh ca ph qun
c. Trong bnh hen, c s gim p ng ca ph qun
d. Khng c ngng thuc tr hen t ngt
14. Cc nhm thuc tr hen
a. Thuc gin ph qun nhm xanthin(theophylline), khng cholin (atropine, ipratropium), kch thch -
adrenergic (salbutamol, cng giao cm khc)
b. Thuc khng vim corticoid, cromon
c. Thuc khng histamine, khng leucotrien, khng sinh
d. C 3 cu trn
15. Tnh cht khng phi ca theophylline
a. Phn ng vi AgNO3 v Co(NO3)2 to cc mui kt ta tng ng
b. Tan trong nc, cn, dd hydroxid kim, ammoniac, acid v c
c. Phn ng murexit
d. Phn ng ghp i vi mui diazoni to phm mu azoic mu
16. C ch tc ng ca theophylline, chn cu sai
a. Gin mch, gim co tht, li tiu
b. c ch men phosphodiesterase lm gim cAMP
c. Lm thay i nng calci ti c trn, c ch s phng thch histamine, leucotrien ti t bo Mast
d. c ch prostaglandin, c ch receptor adenosine
17. Cc thuc lm gim nng theophylline
a. macrolid, propanolol, thuc nga thai ng ung, fluroquinolon
b. carbamazepin, isoproterenol, phenobarbital, phenyltoin, rifampicin
c. cimetidin, allopurinol, erythromycin
d. C 3 cu trn u ng
18. Chn cu sai v ipratropium
a. Bn tng hp t atropine bng phn ng methyl ha vi methyl bromid
b. Tc dng khng muscarin (cnh tranh ti receptor cholinergic) lm gin c trn kh qun
c. Nn dng ring l mt mnh
d. Cho phn ng Vitali-Moren
19. Chng ch nh-thn trng dng ipratropium trong trng hp no l khng ng
a. Nhy cm vi alcaloid benladon
b. Glaucom gc m
c. Ph i tuyn tin lit
d. Ph n c thai/cho con b
20. Zafirlukast
a. Tc dng i khng chn lc trn th th cysteinyl leukotrien D4 v E4
b. Dng trong cp cu cn kch pht cp tnh
c. Thc n lm tng hp thu zafirlukast do nn dng thuc trong ba n
d. Phi tng liu steroid khi dng Zafirlukast
Phn 2. Cu hi ngn
1. Ho l mt ..(1) ca c th, nhm y ra ngoi cc
.(2) khi h thng tiu mao lm sch cht nhy b ri lon
2. Trung tm h hp c kch thch bi nng (1), (2) trong mu
3. Cu to ng h hp gm: 9

23
 Dc chnh quy 2012
4. Ho gm 3 giai on: Ht vo gp . ln V; ng thanh mn, ..; th ra, m
thanh mn, phng thch kh.
5. Thuc ho c c ch giao cm l .(1), .(2)
6. ng phn quang hc ca dextromethorphan l
7. Dextromethorphan dng khng tan trong nc
8. Acetylcystein cha ho bng c ch
9. nh tnh acetylcystein, thm dung dch natri nitroprusiat v ammoniac s xut hin
mu.
10. Theophyllin l mt alkaloid nhn .(1) trong l tr, ht c ph, c th iu ch t
..(2) hay tng hp ton phn
11. Trnh hoc dung rt thn trng theophylline cho bnh nhn c bnh .(1),
(2), gt, tiu ng, thiu nng tun hon no, thiu oxy mu nng, tng huyt p,
tng nhn p, basedow
12. So vi atropine, ipratropium khng .(1), khng.(2)
p p
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
b d a d a a a c b d d c c d b b b c b a

1. phn x bo v, cht tit ca ph qun

2. H+, CO2
3. cc xoang, khoang mi, ming, hu, thanh qun, kh qun, ph qun, cung phi, ph nang
4. 1.5-2, co c
5. ephedrin, pseudoephedrine
6. levomethorphan
7. base
8. lm tan m
9. tm thm
10. purin, cafein
11. tim mch, lot d dy
12. lm c m nhy, nh hng n tim

X. THUC AN THN, GY NG, CHNG NG KINH

Cu 1: Cc pht biu sau y khi so snh gia dn cht benzodiazepin v dn cht barbiturat lad ng, ngoi
tr:
A. Benzodiazepin t gy nghin thuc so vi barbiturat
B. Benzodiazepin t tng tc thuc hn so vi barbiturat
C. Benzodiazepin khng gy bt c tc dng ph khng mong mun no
D. Benzodiazepin c ch h hp mc nh hn so vi barbiturat
Cu 2: c tc ng chng ng kinh tt, nhm th C5 phi l nhm:
A. Benzyl
B. Isopropyl
C. Phenyl
D. Benzoyl
Cu 3: C ch tc ng ca thuc chng ng kinh, ngoi tr:
A. Tng cng hot ng ca GABA
B. Duy tr nng GABA ti khe synap
C. c ch s phn hy glutamat
D. c ch cnh tranh vi glutamat trn th th
Cu 4: Cc dn cht 1,4-benzodiazepin c tc ng an thn v/hoc gy ng, trong cu trc cc cht ny
lun c:
A. Mt nhm phenyl ti C3
B. Mt nhm phenyl ti C5
C. Mt nhm phenyl ti N4
D. Mt nhm phenyl ti N1

24
 Dc chnh quy 2012
Cu 5: Cht i khng benzodiazepin, c cu trc thay i nh th no?
A. Thay vng C bng nhm hydroxyl, v N-methyl v tr s 1
B. Thay vng C bng nhm ceto, v N-methyl v tr s 1
C. Thay vng C bng nhm hydroxyl, v N-methyl v tr s 4
D. Thay vng C bng nhm ceto, v N-methyl v tr s 4
Cu 6: GABA l cht trung gian dn truyn xung thn kinh v l cht iu ha trung gian thn kinh c cu
trc:
A. Acid monocarboxylic
B. Acid monoamin dicarboxylic
C. Acid diamin dicarboxylic
D. Acid monoamin monocarboxylic
Cu 7: C ch tc ng ca thuc chng ng kinh tc ng trn knh ion c th l:
A. ng knh Natri, Calci v m knh Clorid
B. ng m knh Natri, Calci linh hot
C. M knh Natri, Calci v m knh Clorid
D. ng knh Natri, Calci v m knh Clorid
Cu 8: Thuc c tc ng kch thch hot ng ca th th GABA v m dng clorid i vo trong neuron:
A. Topiramat
B. Ethosuximid
C. Phenobarbital
D. Phenytoin
Cu 9: Chn cc nhm th ph hp vi cu trc ha hc ca flunitrazepam:
A. C7= F v C5= 2-nitrophenyl
B. C7= NO2 v C5= 2-fluorophenyl
C. C7= NO2 v C5= 3-fluorophenyl
D. C7= NO2 v C5= 4-fluorophenyl
Cu 10: Vai tr ca gc phenyl trong cu trc cc dn cht 1,4-benzodiazepin (an thn):
A. To hiu ng tt v khng gian gip thuc tip cn c th th
B. Tng tnh thn du ca thuc
C. To cc lin kt gia thuc vi th th mnh hn
D. Va to hiu ng khng gian gip thuc tip cn th th, va tng tnh thn du ca thuc
Cu 11: Thuc tc ng c ch glutamat trong iu tr ng kinh:
A. Diazepam
B. Phenytoin
C. Topiramat
D. Phenobarbital
E. Acid valproic
Cu 12: C th nh tnh Phenytoin bng phng php no?
A. IR
B. Sc k lp mng
C. Phn ng mu vi CuSO4
D. C 3 phng php trn u ng
Cu 13: C ch tc ng ca Valproic:
A. c ch knh Na, lm thay i p ng vi GABA, lm tng lng GABA
B. M knh Na, lm thay i p ng vi GABA, lm gim lng GABA
C. c ch knh Na, khng lm thay i p ng vi GABA, lm tng lng GABA do gim chuyn
ha GABA
D. M knh Na, khng lm thay i p ng vi GABA, lm tng lng GABA do gim chuyn ha
GABA
Cu 14: Trong cu trc benzodiazepin, khi thay th Oxi bng nguyn t no, thuc vn c tc dng gii lo
u v to tng tc chuyn bit hn:
A. N
B. S
C. F
D. Cl
25
 Dc chnh quy 2012
Cu 15: C th nh lng barbitura bng phng php no?
A. Phng php o acid
B. Phng php mi trng khan
C. Phng php o bc
D. Phng php o brom
E. C 4 phng php trn u ng
p n:
1. C 6. D 11. D
2. C 7. A 12. D
3. C 8. C 13. C
4. B 9. B 14. B
5. D 10. D 15. E

XI. THUC GY M
1. Thuc no sau y thuc nhm tin m:
a. Meprobamat
b. Hydroxyzin
c. Atropin
d. Tt c u ng.

2. Thuc m no sau y thuc nhm benzodiazepin

a. Di K clorazepat
b. Etomidat
c. Natri thiopental
d. Meprobamat

3. Cng thc sau y l ca:

a. Alimemazin
b. Hydroxyzin
c. Flunitrazepam
d. Meprobamat

4. nh lng Natri thiopental bng:

a. Co(NO3)2 v CaCl2/ NaOH
b. Acid base
c. CH3OLi / MeOH, dung mi dimethylformamid
d. B,C ng.

5. Cng thc no sau y l ca Ketamin:

A B C D

6. Phng php nh lng Ketamin:

a. MT khan
26
 Dc chnh quy 2012
b. Acid base
c. UV
d. Tt c u ng

7. Phng php nh lng Fentanyl:

a. MT khan
b. Acid base
c. UV
d. Tt c u ng
8. Cu no sau y v Fentanyl l SAI:
a. L dn cht morphine.
b. Ch dng ng tim
c. C tc dng gim au > 100 morphine
d. C cu trc xng sng gim au

9. Thu c gy m b ng ung tim c c u trc l dn ch t barbituric

a.Propofol
b.Thiopental
c.Phenobarbital
d.Pentobarbital

10. Ban ch t cua thu c gy m b ng ung h h p l dn ch t halogen cua.

11. Co ch tc ng cua thu c gy m thiopental v propofol b ng ung tim.

12. Trong cu trc ca thuc m halothan, pht biu no sau y ng:

a. S lng halogen t s lm tng c tnh
b. Br tng kh nng st khun
c. Dng trans c hn dng cis
d. F lm tng kh nng gy m

13. V cu trc ca halothan:......

TR LI
1. D 4. D 7. A
2. A 5. C 8. B
3. D 6. B 9. B
10. Ethan (Halothan) C2HxHal
11. kch thch thu th GABA.
12. D

13.

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XII. THUC T
1. Ki m gii ha n 2,6-dimethyl anilin l c n thi t cho mt s thu c t, ngoa i tr thu c t:
A.Mepivacain
B.Lidocain
C.Amilocain
D.Bupivacain

2. C u trc cua Cocain sau y :

Pht bi u ng v lin quan gia c u trc v tc ng gy t cua Cocain (SAR), ngoa i tr:
A.Nhm carboxymethyl khng anh hung n tc du ng gy t.
B.Nhm amin c n thi t cho tc du ng gy t v l nhm thn nuc trong phn t
C.Ph n thn nuc lin quan nhi u n tc du ng gy t nhung an ton
D.Nhn trophan khng c n thi t cho tc ng

3. Phn loi cu trc thuc t theo cu trc gm loi l:

4. Thuc t no sau y thuc nhm ether:

a. Procainamid
b. Ether
c. Quinisocain
d. Prilocarin

5. Thuc t no thuc nhm ester:

a. Procainamid
b. Mepivacain
c. Lidocain
d. Tetracain

6. Khi dng thuc t, hn ch dng:

a. Quinolon
b. Sulfamid
c. Betalactam
d. Tt c u ng

7. V cu trc ca lidocaine

8. V cu trc ca procaine

9. nh lng procain:
a. IR
b. UV
c. Phn ng vi KMnO4
d. NaNO2

10. Dealkyl oxy ho lidocaine to sn phm:

a. Glycin xylidid
b. Monoethylglycin xylidid
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 Dc chnh quy 2012
c. Monoethylanilin xylidid
d. Tt c u ng

11. Co ch tc ng cua cc thu c t

TR LI
1. C
2. C
3. 3 loi: amid, ester v ether
4. C
5. D
6. B

7. 8.
9. D
10. B
11. c ch knh Na t bn trong t bo

XIII. THUC GIM AU GY NGHIN

1. Tc du ng giam au cua cc ch t c u trc tuong t morphin bi anh hung bi cc nhm chc no sau y
A. C u n i ether
B. Nhm th ngoa i bin v N bc 3 vi nhm th nho
C. Cc nhm th ngoa i bin
D. N bc 3 vi nhm th nho

2. Nhm OH phenol cua Morphin c th ta o phan ng no sau y?

A. Phan ng ta o mu i vi dung dich
NH4OH
B. Phan ng ta o ph m mu azo
C. Phan ng kh nuc
D. Phan ng vi thu c th alkaloid

3. Trn cu trc morphin c my v tr c th thay i:

a. 4
b. 5
c. 6
d. 7

4. y l cu trc ca:

a. Dihydrocodein
b. Papaverin
c. Meperidin
d. Hydrocodon

5. Cc cht c cu trc tng t Methadon c c im g:

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 Dc chnh quy 2012
a. Cn nhm th ngoi vi
b. Khng cn cu ni ether
c. Gy nghin nng hn
d. Khng cn nhm amin

6. Cht ngoi l khng c cu trc xng sng gim au ca morphine nhng vn xp trong nhm gim au
opioid:
a. Diampromid
b. Enkephalin
c. Etonitazen
d. A,C ng

7. Morphine c tnh cht no sau y, ngoi tr:

a. Phn ng to ester v ether
b. Phn ng vi AgNO3
c. Phn ng vi KIO3
d. Phn ng vi ZnCl2
8. Phn ng kh nc ca morphine to sn phm tn:
a. Normorphine
b. Dehydratmorphine
c. Apomorphine
d. Morphan

9. Codein khc morphin im no:

a. Ethoxy OH phenol
b. Methoxy OH phenol
c. Acetyl ho OH phenol
d. Tt c u ng

10. iu no sau y v codein l sai:

a. Khng cho phn ng ca OH phenol
b. Cho phn ng ca alkaloid
c. UV max 284 nm
d. nh lng bng phng php acid base

11. Dn cht hydrogen ho C7-C8, thm OH C14:

a. Dihydromorphinon
b. Dihydrocodeinon
c. Oxycodon
d. Tt c u ng

12. Cu trc ca Naloxon:

13. V cu trc ca morphin
14. V cu trc ca methadone
15. Nu c im cu trc ca xng sng gim au morphine:

TR LI
1. D 4. C 7. D
2. B 5. B 8. C
3. B 6. D 9. B

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 Dc chnh quy 2012
10. D
11. C

12. 13.

14.
15. - N bc 3, nhm th nh
- C trung tm khng ni H
- Nhm phenyl ni C*
- 2C ni C* v N bc 3

XIV. THUC KCH THCH TKTW V THUC CHNG TRM CM

Tm tt l thuyt:
Phn loi thuc kch thch TKTW:
- Thuc tc ng u tin trn v no: chng mt mi, ng g: cafein, ephedrin, amphetamin,
- Thuc tc ng u tin trn hnh no: tc dng kch thch trung tm h hp, tun hon: niketamid,
camphor,
- Thuc kch thch tm thn kinh: tng vn ng, hot ng tr tu: amphetamin, dextro- amphetamin,
fenfluramin,
- Thuc tc ng u tin trn ty sng: tng phn x, hot ng thn kinh c: strychnin
- Thuc chng trm cm: tng lng catecholamin khe synap thn kinh
Cc cht c tc dng ging Amphetamin:

Thuc chng trm cm: u nhm duy tr cc amin dn truyn thn kinh, gm:
- Thuc chng trm cm 3 vng:
Cu trc Tn thuc
Dibenzoazepin Imipramin, Desipramin, Clomipramin, Trimipramin
Dihydrodibenzoazepin Opipamol
Dibenzocycloheptadien Nortriphylin, Amitriphylin, Noxiptylin, Cyproheptadin
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Dibenzocycloheptatrien Protriptylin
Dibenzoxepin Doxepin
Dibenzothiepin Dothiepin
Dn cht Dibenzooxazepin Amoxapin, Propizepin
Thuc th h 2 Amineptin, Mianserin, Metapramin, Tianepin
- Thuc chng trm cm chn lc serotonin: Fluoxetin, Paroxetin
- Thuc chng trm cm c ch Monoaminooxydase (IMAO): Tranylcypromin sulfat
- Cc thuc khc
Trc nghim:
Cu 1: Pht biu sau y l chnh xc vi thuc chng trm cm ngoi tr:
A. Sau khi triu chng bnh gim bt cn tip tc ung thuc trong thi gian ti thiu l 6 thng
B. Thuc iu tr trm cm ch pht huy tc dng y sau 3-6 tun iu tr lin tc
C. Tm l liu php cn c phi hp khi iu tr trm cm
D. Cc thuc chng trm cm u nhm duy tr cc amin dn truyn thn kinh ( serotonin v
norepinephrin) ti synap thn kinh
Cu 2: Fluoxetin l thuc chng trm cm thuc nhm c ch ti hp thu chn lc serotonin c cu trc
c thit k t:
A. Venlafaxin
B. Tranylclopromin
C. Diphenhydramin
D. Amitriptylin
Cu 3: Thuc tc ng ch yu vo h thn kinh ty sng khi s dng liu iu tr:
A. Dihydrostrychnin sulfat
B. Strychnin sulfat
C. Strychnan sulfat
D. Brucin sulfat
Cu 4: Amphetamin thng c s dng di dng:
A. Hu trin
B. dng ng phn dextro amphetamin
C. Hn hp racemic
D. Tt c u ng
Cu 5: Tc dng ca cafein:
A. Kch thch TKTW
B. Dn ph qun
C. Li tiu
D. Tt c
Cu 6: Cht no sau y khi phn ng vi AgNO3 cho kt ta mu trng:
A. Cafein
B. Theophyllin
C. Theobromin
D. Tt c
Cu 7: Cht no sau y cho kt qu m tnh khi th vi thuc th Mayer/picric:
A. Cafein
B. Theophyllin
C. Theobromin
D. Khng c cht no
Cu 8: Cafein c nh tnh bng phng php:
A. Phn ng vi AgNO3
B. Phn ng Murexit
C. Phn ng vi CoCl2
D. Tt c
Cu 9: Cafein c nh lng bng phng php:
A. Mi trng khan
B. o iod

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 Dc chnh quy 2012
C. C 2 u ng
D. c 2 u sai
Cu 10: Fluoxetin c nh lng bng phng php:
A. IR
B. UV
C. nh lng ion Cl-
D. HPLC
Cu 11: Trong mi trng kim Caffein b chuyn ha thnh cht g gy ung th? Caffeidin
Cu 12: Amphetamin c iu ch t? Phenylaceton
Cu 13 : V cu trc ng ca Amphetamin?

XV. HORMON TUYN TY

1. Thuc no sau y khng thuc nhm sulfamid h ng huyt th h II:
A. Glipizid
B. Glyburid
C. Gliclazid
D. Glimepirid
E. Carbutamid
2. Thuc no sau y thuc nhm biguanid?
A. Metformin Hydroclorid
B. Carbutamid
C. Clorpropamid
D. Ciglitazon
E. Piglitazon
3. Thuc no sau y thuc nhm c ch Glucosidase?
A. Buformin
B. Phenformin
C. Acetohexamid
D. Acarbose
E. Glyburid
4. Tc dng ph ca Biguanid?
A. H huyt p
B. H ng huyt
C. Lon nhp
D. Nhim acid lactic mu
E. Tng huyt p
5. Acarbose c ch mnh nht trn enzyme:
A. Glucoamylase B. Sucrase
B. Maltase D. Isomaltase
F. Glucoamylase
6. Nn dng sulfamid chng i tho ng khi:
A. 30 pht trc n B. Sng ng dy
C.Trc khi i ng D. Sau ba n
7. Cc thiazolidinedion lm tng tc dng ca insulin trn ng vt khng insulin bng cch ?
A. Tng s lng th th
B. Tng s lng yu t vn chuyn Insulin
C. Tng s lng yu t vn chuyn Glucose
D. Tng s lng phn t hiu ng
8. Thiu mu tn huyt l tc dng ph ca nhm thuc tr i tho ng no?

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 Dc chnh quy 2012
A. Sulfamid th h 1
B. Sulfamid th h 2
C. Sulfonylure
D. Biguanid
9. nh lng Metformin bng phng php no?
A. Acid base trong mi trng nc
B. Chun trong mi trng khan
C. Phng php Oxy ha kh
D. Tt c u sai
10. Tc dng ph ca Metformin?
A. Mt bch cu, thiu mu bt sn
B. Km hp thu, y hi, chng bng
C. Bun nn, tiu chy, thiu B12, chn n
D. Phn ng d ng da, vng da, nhy cm.
p n:
1 2 3 4 5 6 7 8 9 10
E A D D A A C C B C

XVI. HORMON TUYN GIP

Cho cc cng thc sau:

I
II

III
IV

1. Cng thc I l:
a. Thyronin
b. Tyrosin
c. Thyroxin
d. 3,5-diiodotyroxin
2. Cng thc III l:
a. Thyronin
b. Tyrosin
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 Dc chnh quy 2012
c. Thyroxin
d. 3,5-diiodotyroxin
3. Cng thc V l:
a. Thyronin
b. Tyrosin
c. Thyroxin
d. 3,5-diiodotyroxin
4. Hot tnh ca hormone tuyn gip theo th t:
Levothyroxin(1) dextrothyroxin(2) triiodothyronin(3) monoiodothyroxin(4)
a. 1>2>3>4
b. 2>3>4>1
c. 3>2>1>4
d. 3>1>2>4
5. Chn cu sai:
a. Thyroxin tng hp dng racemic
b. Dng t truyn ca thyroxin c hot tnh hormone gip mnh hn dng hu truyn
c. Enzyme xc tc tng hp hormone tuyn gip l hydroxylase
d. Thyroxin c iu ha bi tit bi TSH, TRH
6. Chn cu sai: Bnh cng gip:
a. TSH thp, T3,T4 cao hoc bnh thng
b. S lnh, gim chuyn ha, tng cn
c. Do dng iod qu liu
d. iu tr bng cc thuc khng gip, iod nng cao, ClO4, SCN-, NO3-, glycoside thc
vt,
7. Thuc tr suy gip tr:
a. Thyroid
b. Liothyronin
c. Liotrix
d. KI
8. Cu trc to nn tc dng dc l cu phn ln cc cht khng gip:
a. Cu ether oxygen
b. Ido gn vo vng thm v tr 3,5
c. Nhm SCN-
d. a, b ng
9. propyl thiouracil:
a. l thuc khng gip nhm thioamides
b. iu ch qua 3 giai on
c. nguyn liu tng hp: acetylacetic, thioure
d. a,b,c ng
10. Chn cu ng:
a. Propyl thiouracil chng ch nh cho ph n c thai
b. Methimazol c tc dng mnh hn propyl thiouracil
c. Iod dng trong x tr l iod123
d. Tt c ng
11. Carbimazol thuc nhm:
a. Thuc tr cng gip
b. Thuc tr suy gip
c. Thuc tr bnh n n
d. Khng thuc cc nhm trn
p n: 1c 2b 3a 4d 5c 6b 7d 8c 9d 10b 11a

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 Dc chnh quy 2012
XVII. HOOCMON SINH DC
1. Testosterone chuyn thnh estradiol di tc ng ca enzyme:
A. Aromatase.
B. 17 hydroxysteroid dehydrogenase.
C. 16 hydroxylase.
D. Tt c u sai.

2. Estron chuyn thnh estradiol di tc ng ca enzyme:

A. Aromatase.
B. 17 hydroxysteroid dehydrogenase.
C. 16 hydroxylase.
D. Tt c u sai.

3. Chn cu ng:
A. Estriol c hot tnh estrogen mnh nht, estradiol c hot tnh estrogen yu nht.
B. Estradiol c tit ra bi nhau thai, vo thi k mang thai.
C. Estrogen b gim hot tnh khi dng chung vi Rifampicin.
D. Cc estrogen lin hp c tnh base yu.

4. c im cu trc no ca ethinyl estradiol gip thuc ny bn vi enzyme chuyn ha gan:

A. OH C3.
B. OH C17.
C. OH C17 c ester ha.
D. Nhm CCH.

5. Cht no sau y thuc nhm 19 nortestosterone:

A. Desogestrel, Etonogestrel.
B. Nomegestrol acetat.
C. Medroxyprogesteron acetat.
D. Ethinyl estradiol.

6. Thay i cu trc no ca testosterone c tc dng ko di:

A. Thm ni i C4 v C5.
B. Ester ha OH C17.
C. B nhm methyl v tr C19.
D. Clo ha v tr C11.

7. u im ca cc dn xut testosterone so vi testosterone l:

A. C th ung c.
B. Tc ng di hn.
C. Tc ng chuyn bit hn.
D. Tt c u ng.

8. Mifepriston l:
A. Progesteron (Progestin) tng hp.
B. Testosterone tng hp.
C. Cht i vn th th Progesterone.
D. Estrogen tng hp.
9. Tc dng chnh ca dehydrotestosterone (DHT sn phm chuyn ha ca testosterone di tc ng ca
enzyme 5 reductase):
A. To cc c tnh nam.
B. Kch thch s sinh tinh.
C. Xy dng cc m protein.
D. Lm dy lp nim mc t cung.
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 Dc chnh quy 2012
E. iu ha s tit cc hoocmon sinh dc.

10. Dn xut testosterone c tc ng tin bin protein l:

A. Testosterone propionat (ester ha OH v tr C17).
B. Testosterone acetat (ester ha OH v tr C17).
C. Nandrolon (b nhm methyl C19).
D. Methyl testosterone (Thm nhm CH3 vo v tr C17).

11. ngh 1 phn ng ha hc c th dng nh tnh Ethinyl estradiol.

12. c im cu trc no ca Mestradiol lm thuc c tc dng ko di.

P N:
1A 2B 3C 4D 5A 6B 7D 8C 9A 10C.
11. Phn ng vi AgNO3 to ta trng (do c nhm CCH).
Phn ng vi FeCl3 -> mu tm (do c nhm OH phenol).
12. OCH3 v tr C3 (ether ha nhm OH v tr C3).

LU :
Lin quan cu trc tc ng cc dn cht estrogen:
- Ethinyl estradiol c CCH nn bn vi enz gan.
- Mestranol, OH -> OCH3 (v tr C3) nn c tc dng ko di.
Lin quan cu trc tc ng cc dn cht testosteron:
- V tr C3: C=O cn cho tc ng androgen.
- V tr C4 C5: c ni i lm tng tc ng.
- V tr C9: thm Fl/ Cl lm tng tc dng, gim chuyn ha.
- V tr C17: thm nhm alkyl gip bn vi enz gan.
ester ha OH gip tc dng ko di.
V tr C19: b nhm methyl lm tng tc dng tin bin protein.

XVIII. THUC TR BO PH
1. Amphetamin c ch trung tm i gy chn n c tc dng gim cn. Amphetamin l cht cng giao
cm:
A. trc tip
B. gin tip
C. va trc tip va gin tip
D. Tt c u sai
2. Ephedrin v Amphetamin u c ch trung tm i. Amphetamin c tc dng mnh hn, thn du hn do:
A. mt OH phenol
B. mt OH ancol
C. mt OH phenol v OH ancol
D. c nhm amin bc 1
3. Phn ng mu c trng ca Ephedrin
4. Thuc tr bo ph theo c ch c ch lipase khng thun nghch c dng nhiu hin nay
A. Sibutramine
B. Orlistat
C. Phentermine
D. Phenylpropanolamin
5. Thuc no sau y c tc ng gim bo KHNG do c ch ti hp thu NE hay dopamine ti khe synape
A. Diethylpropion
B. Phentermine
C. Amphetamine
D. Pseudoephedrin

6. Cho CT Amphetamine , v CT Benphetamine..

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 Dc chnh quy 2012
7. Vai tr ca Natrexone trong phi hp Natrexone + Bupropion:..
8. nh lng Benphetamine HCl bng chun mi trng khan vi mi trng l acid acetic bng v
., cht ch th., cht chun l..
9. Fenfluramine l dn cht ca Amphetamine, tn gi ca Fenfluramine theo Amphetamine
.
10. Cht no c ngun gc thc vt, gm 6-8 acid bo gn vi li sucrose khin enzyme ca c th khng
thy phn c, to cm gic no v tr bo ph:
A. Olestra
B. Orlistat
C. Lorcaserin
D. Manzidol
11. Thuc no dng lu ngy s gy suy kit ngun vitamin tan trong du:
A. Olestra
B. Orlistat
C. Phenmetrazine
D. A, B ng.
12. Cc thuc no KHNG nn s dng chung vi thuc c ch MAO
A. Sibutramine
B. Phendimetrazine
C. Manzidol
D. C A, B, C
13. Khng nn s dng cc thuc cng giao cm gin tip tr bo ph vi c ch MAO v c kh nng gy
hi chng
14. Tp sinh ra trong qu trnh tng hp Naltrexone cn kim nghim l:
15. Cht cng giao cm gin tip dng thay th cho Amphetamine v Phenmetrazine v khng c tc dng
kch thch thn kinh v gy nghin
A. Sibutramine
B. Manzidol
C. Benphetamine
D. Diethylpropion
P N
1.B
2.C
3.to phc tm tan trong ether vi CuSO4
4.B
5. A

6. .
7. c ch c ch feedback ca -endorphin ln POMC- tin cht ca - MSH v -endorphin c vai tr trong
iu chnh s thm n.
8. acetat thy ngn/tm tinh th/acid percloric
9. 3-trifloromethyl-N-ethylamphetamine
10. A
11. D
12. D
13. serotonin
14. noroxymorphone
15. D

38