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Throtropin receptor
Cytokinase
Low thyrotropin
Increase glycosamino
Antibody
Retro-orbital fibroblast
Hipertiroidisme
TSH menurun
T3 & T4
Elektrolit imbalance
Hipertiroidisme
T3 masuk nucleus
Electricsl remodelling
aritmia
In Graves disease, B and T lymphocyte-mediated autoimmunity are known to be
directed at 4 well-known thyroid antigens: thyroglobulin, thyroid peroxidase,
sodium-iodide symporter, and the thyrotropin receptor. However, the thyrotropin
receptor itself is the primary autoantigen of Graves disease and is responsible for
the manifestation of hyperthyroidism. In this disease, the antibody and cell-
mediated thyroid antigen-specific immune responses are well defined. Direct
proof of an autoimmune disorder that is mediated by autoantibodies is the
development of hyperthyroidism in healthy subjects by transferring thyrotropin
receptor antibodies in serum from patients with Graves disease and the passive
transfer of thyrotropin receptor antibodies to the fetus in pregnant women.
(Medscape)