Malfunctioning Dendritic Cells Tumour Necrosis Factor Alpha Secretion of inflammatory chemical signals (cytokines) Secretion of tumor necrosis factor- Secretion of interleukin-1 Secretion of interleukin-6 Secretion of interleukin-36 Secretion of interleukin-22 Infiltration of Activated CD4+ lymphocytes to Dermis & Epidermis Infiltration of Activated CD8+ lymphocytes to Dermis & Epidermis