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Drugs with PVC Leaching - tic, tac, toe, craving delicious pho!
Tacrolimus
Tesirolimus
Teniposide
Cabazitaxel
Docetaxel
Paclitaxel
Select IV Drugs
Amiodarone - stable for 24hrs in polyolefin/glass, only 2hrs in PVC - use D5W only
Amphotericin B - use D5W only
Furosemide - IV:PO is 1:2 - protect from light, do not give if solution is yellow
Levothyroxine - IV:PO is 1:2 - protect from light
Metronidazole - IV:PO is 1:1 - protect from light
Phenytoin - IV:PO is 1:1 - max infusion rate 50mg/min - use in-line filter and saline flush
SMX/TMP - IV:PO is 1:1 - use D5W only - protect from light - stability based on concentration
Shock
Dobutamine - B agonist - for Cardiogenic Shock
Norepinephrine - a > B - DOC for Septic Shock - Brand Levophed
If extravasation of NE occurs treat with Phentolamine
With Clozapine must have WBC > 3500 and ANC > 2000
FGA > SGA can cause neuroleptic malignancy syndrome - treat with DANTROLENE
Drug Interactions:
Strong CYP Inducers - PS PORCS
Phenytoin/Fosphenytoin
Smoking
Phenobarb/Primidone
Oxcarbazepine
Rifampin
CBZ
StJW
Topiramate > 200mg
Drugs That Are Highly Protein Bound and Can Displace Each Other
Phenytoin
Depakote
Warfarin
Salicylates (including pepto)
BBs
BB + ISA = CAPP - Carteolol, Acebutolol, Pindolol, Penbutolol
B1 Selective = AMEBBA - Atenolol, Metoprolol, Esmolol, Bisoprolol, Betaxolol, Acebutolol
HF Drugs - ACE+BB for everyone, may add loop, aldosterone antagonist, dig, or hydralazine+nitrate(AA)
BBs - metoprolol succinate (ER), carvedilol, bisoprolol