Major Histocompatibility Complex

Immunology Saturday, March 19, 2016

Principles of Immune Response
Highly specific recognition of foreign antigens
Mechanisms for elimination of microbes bearing such
antigens
A vast universe of distinct antigenic specifies
Immunologic memory
Tolerance of self-antigens

Immunology Saturday, March 19, 2016

 Distinct Cells in Immune System
Lymphocytes (B cells, T cells)
- Determining specificity of immunity
Monocyte/macrophage, dendritic cells, natual killer cells and
other members of myeloid cells
- Antigen presentation
- Mediation of immunologic functions
Specialized epithelial and stromal cells
- Providing anatomic environment

Immunology Saturday, March 19, 2016

T Lymphocytes
Helper (CD4+) and Cytotoxic (CD8+) T cells
Help B cells develop into antibody-producing cells (HTL)
Directly killing of target cells (CTL)
Enhance the capacity of monocytes and macrophage
Secretion of cytokines

Immunology Saturday, March 19, 2016

Major Histocompatibility Complex (MHC)
Transfer of information about proteins within a cell to
the cell surface
MHC I are expressed on the great majority of cells and
recognized by CD8+ T cells
MHC II are expressed on B cells, macrophages, dendritic
cells and recognized by CD4+ T cells
Responsible for graft rejection
Found on chromosome 6 in human and 17 in mouse

Immunology Saturday, March 19, 2016

Immunology Saturday, March 19, 2016
Antigen Presentation Pathway MHC I
Intracellular
antigens
Viruses

Immunology Saturday, March 19, 2016

Immunology Saturday, March 19, 2016
Antigen Presentation Pathway MHC II
Extracellular
antigens
Bacteria and
Parasites

Immunology Saturday, March 19, 2016

Immunology Saturday, March 19, 2016
 Antigen Presentation Pathways
Saturday, March 19,
Immunology
2016
TCR/peptide-MHC Complex

Immunology Saturday, March 19, 2016

T Cell Activation

Immunology Saturday, March 19, 2016

One Receptors, Two Kinds of Signals

Immunology Saturday, March 19, 2016

X-ray Crystal Structures

Immunology Saturday, March 19, 2016

Peptides Binding to MHC Molecules
MHC I molecules bind short peptides, usually between 8 and
10 residues.
The typical length of a class I ligand comprises 9 amino acids.
Class II ligands consist of 12 to 25 amino acids.
A core of nine amino acids is essential for peptide/MHC
binding.

Immunology Saturday, March 19, 2016

MHC peptide prediction
Understanding the basis of immunity
Development of peptide vaccines
Immunotherapeutics for cancer and autoimmune disease
Several mathematical approaches for MHC peptide binding
prediction

Immunology Saturday, March 19, 2016