Professional Documents
Culture Documents
Diseases
Exploration Of Harm In The Human Body
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Coronary Artery
Disease(CAD)
Epidemiology
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In 2015 CAD affected 110 million people and resulted in 8.9 million deaths. It makes up 15.9% of all
deaths makes it the most common cause of death globally. The risk of death from CAD for a given
age has decreased between 1980 and 2010 especially in developed countries.The number of cases
of CAD for a given age has also decreased between 1990 and 2010. In the United States in 2010
about 20% of those over 65 had CAD, while it was present in 7% of those 45 to 64, and 1.3% of
those 18 to 45. Rates are higher among men than women of a given age. (Lancet,2015)
Picture link 1
Transmission/Causes
Coronary artery disease is thought to begin with damage or injury to the inner layer of a
coronary artery, sometimes as early as childhood. The damage may be caused by various
factors, including: (Mayo 2015)
Smoking
High blood pressure
High cholesterol
Diabetes or insulin resistance
Sedentary lifestyle
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CAD is caused by plaque buildup in the walls of the arteries that supply blood to the heart
(called coronary arteries) and other parts of the body. Plaque is made up of deposits of
cholesterol and other substances in the artery. Plaque buildup causes the inside of the arteries
to narrow over time, which could partially or totally block the blood flow. This process is called
atherosclerosis.
Too much plaque buildup and narrowed artery walls can make it harder for blood to flow through
your body. When your heart muscle doesnt get enough blood, you may have chest pain or
discomfort, called angina. Angina is the most common symptom of CAD.
Over time, CAD can weaken the heart muscle. This may lead to heart failure, a serious
condition where the heart cant pump blood the way that it should. An irregular heartbeat, or
arrhythmia, also can develop. (Mayo 2015) Picture link 2
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Chest pain (angina). You may feel pressure or tightness in your chest, as if
someone were standing on your chest. This pain, referred to as angina, usually
occurs on the middle or left side of the chest. Angina is generally triggered by
physical or emotional stress.
The pain usually goes away within minutes after stopping the stressful activity. In
some people, especially women, this pain may be fleeting or sharp and felt in the
neck, arm or back.
Shortness of breath. If your heart can't pump enough blood to meet your body's
needs, you may develop shortness of breath or extreme fatigue with exertion.
Heart attack. A completely blocked coronary artery may cause a heart attack. The
classic signs and symptoms of a heart attack include crushing pressure in your
chest and pain in your shoulder or arm, sometimes with shortness of breath and
sweating.
Women are somewhat more likely than men are to experience less typical signs
and symptoms of a heart attack, such as neck or jaw pain. Sometimes a heart
attack occurs without any apparent signs or symptoms. (Mayo 2015)
Diagnosis
To find out your risk for CAD, your health care team may measure your blood pressure, cholesterol, and
sugar levels. Being overweight, physical inactivity, unhealthy eating, and smoking tobacco are risk
factors for CAD. A family history of heart disease also increases your risk for CAD. If youre at high risk
for heart disease or already have symptoms, your doctor can use several tests to diagnose CAD.
(HHS 2015)
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ECD or EKG Measures the electrical activity, rate, and regularity of your heartbeat.
(electrocardio
gram)
Echocardiogra Uses ultrasound (special sound wave) to create a picture of the heart.
m
Exercise Measures your heart rate while you walk on a treadmill. This helps to determine how
stress test well your heart is working when it has to pump more blood.
Chest X-ray Uses x-rays to create a picture of the heart, lungs, and other organs in the chest.
Cardiac Checks the inside of your arteries for blockage by inserting a thin, flexible tube through
catheterizatio an artery in the groin, arm, or neck to reach the heart. Health care professionals can
n measure blood pressure within the heart and the strength of blood flow through the
hearts chambers as well as collect blood samples from the heart or inject dye into the
arteries of the heart (coronary arteries). (HHS 2015)
Coronary Monitors blockage and flow of blood through the coronary arteries. Uses X-rays to
angiogram detect dye injected via cardiac
Quit smokingor better yet, never start. Smoking is considered one of the key risk factors for
heart attack. Also steer clear of secondhand smoke. If a household member is a smoker, help him
or her find ways to quit, such as calling your states free 800-QUIT-NOW line, suggests Martin.
Eat less of the foods that add to heart problems, and more of the foods that protect the
heart. Aim for an eating plan thats low in saturated fats and trans fats, higher in
monounsaturated and polyunsaturated the fats found in olive oil and fish, high in fiber (found in
plant foods), and low in salt and sugar. Get practical ideas to eat for heart health in Eat Smart.
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(Martin 2013)
Become more active, and stay active, all through life. A good goal is at least 150 minutes (2.5
hours) of moderate exercise each week, or 75 minutes (1.25 hours) of vigorous aerobic exercise
each week. Or aim to be active for 30 minutes a day, most days of the week. Check with your
doctor before you launch a new workout program if youve never worked out before. Learn how
implementing an exercise routine helps your heart in Move More.(Martin 2013)
Keep your weight within the normal range on a Body Mass Index (BMI) chart. If youre
overweight, losing just 5 percent to 10 percent of your current weight will lower your risk of
developing coronary artery disease.(Martin 2013)
Find healthy outlets for your stress. Some stress is unavoidable in life. But it tends to push us
toward not-so-great habits (overeating, drinking, sitting too much). Youll be more heart-healthy if
you can offload stress in ways you enjoy and that are good for you, such as exercise, meditation
and relaxing with friends, says McEvoy. A stress-management program can help.(Martin 2013)
Prescription
Various drugs can be used to treat coronary artery disease, including: (Martin 2013)
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pressure, which decreases your heart's demand for oxygen. If you've had a
heart attack, beta blockers reduce the risk of future attacks. (Martin 2013)
Nitroglycerin. Nitroglycerin tablets, sprays and patches can control chest
pain by temporarily dilating your coronary arteries and reducing your heart's
demand for blood.(Martin 2013)
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II
receptor blockers (ARBs). These similar drugs decrease blood pressure
and may help prevent progression of coronary artery disease. (Martin 2013)
Procedures to restore and improve blood flow
Sometimes more aggressive treatment is needed. Here are some options: (Martin 2013)
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Image 3
References
Epidemiology sites:
(1) GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016).
"Global, regional, and national incidence, prevalence, and years lived with disability for 310
diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study
2015.". Lancet
GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). 2015.". Lancet
(London, England). 388 (10053): 14591544. doi:10.1016/S0140-6736(16)31012-1. PMID
27733281 (Lancet,2015)
https://en.wikipedia.org/wiki/Coronary_artery_disease#Signs_and_symptoms
Picture:
(1)Picture 1
(2)Picture 2
(3)Picture 3
Transmission:
By Mayo Clinic Staff Dec. 11, 2015. Mayo Clinic (Mayo 2015)
http://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/symptoms-causes/dxc-20165314
https://www.cdc.gov/heartdisease/coronary_ad.htm
Diagnosis:
U.S. Department of Health & Human Services HHS/Open USA.gov August 10, 2015 (HHS 2015)
https://www.cdc.gov/heartdisease/coronary_ad.htm
Cures:
Seth Martin, M.D., M.H.S., of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. The Johns
Hopkins University October, 2013 (Martin 2013)
http://www.hopkinsmedicine.org/health/healthy_heart/diseases_and_conditions/coronary-artery-disease-
prevention-treatment-and-research
Prescription:
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Seth Martin, M.D., M.H.S., of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. The Johns
Hopkins University October, 2013 (Martin 2013)
http://www.hopkinsmedicine.org/health/healthy_heart/diseases_and_conditions/coronary-artery-disease-
prevention-treatment-and-research
Ebola(EHF)
Epidemiology
.The Ebola outbreak in West Africa was first reported in March 2014, and rapidly
became the deadliest occurrence of the disease since its discovery in 1976.
In fact, the epidemic killed five times more than all other known Ebola outbreaks
combined.
More than 21 months on from the first confirmed case recorded on 23 March 2014,
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11,315 people have been reported as having died from the disease in six countries;
Liberia, Guinea, Sierra Leone, Nigeria, the US and Mali.
The total number of reported cases is about 28,637. But on 13 January, 2016, the World
Health Organisation declared the last of the countries affected, Liberia, to be Ebola-free
Transmission
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Are patients who recover from Ebola immune for life? Can they get it again - the
same or a different strain?
Recovery from Ebola depends on good supportive care and the patients immune
response. Evidence from previous Ebola outbreaks shows that people who survived the
disease had antibodies to the virus that could still be detected 10 years after recovery.
We dont know if people who recover are immune for life or if they can become infected
with a different species of Ebola.
Some viruses, including Ebola, can linger for some time after recovery in parts of the
body (for example, testes, eyes, spinal column fluid) not easily reached by the immune
system. CDC and other researchers continue to study this issue and will share
information as it becomes available.(DOH,2016)
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There is no known risk of getting Ebola through casual contact with an Ebola survivor.
We do not yet know if those who have the virus in certain parts of the body (such as the
eyes or spinal column) pose any risk of spreading the virus to others, including
healthcare providers, through invasive surgical procedures. CDC and other researchers
continue to study this issue and will share information as it becomes available.
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Can Ebola be spread through mosquitoes?
There is no evidence that mosquitoes or other insects can transmit Ebola virus. Only
mammals (for example, humans, bats, monkeys and apes) have shown the ability to
spread and become infected with Ebola virus.
FDA is considering issuing guidance for blood establishments related to this issue. CDC
has no recommendations at this time.
Once the virus enters the body, it targets several types of immune cells that
represent the first line of defense against invasion. It infects dendritic cells, which
normally display signals of an infection on their surfaces to activate T lymphocytes
the white blood cells that could destroy other infected cells before the virus
replicates further. With defective dendritic cells failing to give the right signal, the T
cells dont respond to infection, and neither do the antibodies that depend on them
for activation. The virus can start replicating immediately and very quickly.
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Ebola, like many viruses, works in part by inhibiting interferona type of molecule
that cells use to hinder further viral reproduction. In a new study published today in
Cell Host & Microbe, researchers found that one of Ebolas proteins, called VP24,
binds to and blocks a transport protein on the surface of immune cells that plays an
important role in the interferon pathway.
Curiously, lymphocytes themselves dont become infected with the virus, but a series of
other factorsa lack of stimulation from some cells and toxic signals from others
prevent these primary immune cells from putting up a fight.
Symptoms may appear anywhere from 2 to 21 days after exposure to Ebola, but the
average is 8 to 10 days.
Diagnosis: Ebola
Diagnosing Ebola in a person who has been infected
for only a few days is difficult because the early
symptoms, such as fever, are nonspecific to Ebola infection and often are seen in
patients with more common diseases, such as malaria and typhoid fever.
However, a person should be isolated and public health authorities notified if they have
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the early symptoms of Ebola and have had contact with
blood or body fluids from a person sick with or who has died from Ebola,
objects that have been contaminated with the blood or body fluids of a person
sick with or who has died from Ebola,
infected fruit bats and primates (apes and monkeys), or
semen from a man who has recovered from Ebola
Samples from the patient can then be collected and tested to confirm infection.
Ebola virus is detected in blood only after onset of symptoms, most notably fever, which
accompany the rise in circulating virus within
the patient's body. It may take up to three
days after symptoms start for the virus to
reach detectable levels. Laboratory tests used
in diagnosis include:
Three potential immunisations are frontrunners, having been rushed from promising
animal studies into human trials.
One is produced by GlaxoSmithKline (GSK) and the National Institutes of Health in the
US, another is being developed by the Public Health Agency of Canada in collaboration
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with Merck.
And the third to enter human testing is made by Johnson and Johnson together with the
company Bavarian Nordic.
The plan is for the different vaccines to be tested in several separate trials across the
three worst affected countries in the next few months.
GSK's version uses a chimpanzee common cold virus to carry a single Ebola protein.
The vaccine cannot trigger either disease but the hope is it will prompt the production of
protective antibodies against Ebola.
They have three separate parts. Scientists hope to recruit 10,000 people to be given the
GSK vaccine, 10,000 to receive the Merck jab and a further 10,000 to get a dummy,
placebo vaccine.
So far the GSK and Merck vaccines have been deemed safe in some 600 volunteers.
Further testing is underway to see whether the immunizations actually offer protection
against the disease.
The Merck vaccine used in the Liberian trial is based on a livestock virus, carrying a
single Ebola gene.
It is also being trialled in a separate study in Guinea. Here it is being given to anyone
who has recently come into contacted with an infected person.
Johnson and Johnson announced the start of their vaccine trial at the beginning of
2015. This uses a different approach still - two separate jabs will be given in the hope
the second one boosts the effectiveness of the first.
Vaccine company Novavax has recently announced the start of an Australian trial
designed to investigate another potential immunization on healthy human volunteers.
The World Health Organization (WHO) is also evaluating developments in Russia and
Japan. (Servick,2014)
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Prevention
The best way to avoid catching the disease is by not traveling to areas where the virus
is found.(Servick,2014)
References:
http://www.cdc.gov/vhf/ebola/about.html February 18, 2016,U.S. Department of Health & Human
Services(DoH, 2016)
http://www.sciencemag.org/news/2014/08/what-does-ebola-actually-do
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Pneumonia
Epidemiology
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Pneumonia affects approximately 450 million people globally (7% of the population) and results in
about 4 million deaths per year. Pneumonia was regarded by William Osler in the 19th century as
"the captain of the men of death". With the introduction of antibiotics and vaccines in the 20th
century, survival improved.Nevertheless, in developing countries, and among the very old, the very
young, and the chronically ill, pneumonia remains a leading cause of death. Pneumonia often
shortens suffering among those already close to death and has thus been called "the old man's
friend".(Murdoch,2011)
http://www.who.int/bulletin/volumes/86/5/07-048769-F2.jpg
A person who is sick with M. pneumoniae infection has these bacteria in their nose, throat, windpipe,
and lungs. M. pneumoniae is transmitted (spread) from person-to-person when small droplets of water
that contain the bacteria get into the air and people breathe them in. People who are sick with M.
pneumoniae infection usually spread the disease by coughing or sneezing while in close contact with
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Most people who are exposed for a short amount of time to someone with M. pneumoniae infection do
not become ill. M. pneumoniae infections are known to have long incubation periods (the time between
first catching the bacteria from an ill person and development of symptoms). However, it is common for
this illness to spread between family members who live together. The incubation period is usually
between 1 to 4 weeks.(McMahan,2016)
Outbreaks occur mostly in crowded settings like schools, college dormitories, military barracks,
nursing homes, and hospitals. Transmission of M. pneumoniae to the community has been seen during
school-based outbreaks, with most community cases thought to be family members of ill school
Many germs can cause pneumonia. The most common are bacteria and viruses in the air we
breathe. Your body usually prevents these germs from infecting your lungs. But sometimes
these germs can overpower your immune system, even if your health is generally good.
Pneumonia is classified according to the types of germs that cause it and where you got the
infection.
Community-acquired pneumonia
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Community-acquired pneumonia is the most common type of pneumonia. It occurs outside of
hospitals or other health care facilities. It may be caused by:
Some people catch pneumonia during a hospital stay for another illness. Hospital-acquired
pneumonia can be serious because the bacteria causing it may be more resistant to antibiotics
and because the people who get it are already sick. People who are on breathing machines
(ventilators), often used in intensive care units, are at higher risk of this type of pneumonia.
Health care-acquired pneumonia is a bacterial infection that occurs in people who live in long-
term care facilities or who receive care in outpatient clinics, including kidney dialysis centers.
Like hospital-acquired pneumonia, health care-acquired pneumonia can be caused by bacteria
that are more resistant to antibiotics.
Aspiration pneumonia
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Aspiration pneumonia occurs when you inhale food, drink, vomit or saliva into your lungs.
Aspiration is more likely if something disturbs your normal gag reflex, such as a brain injury or
swallowing problem, or excessive use of alcohol or drugs.
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Newborns and infants may not show any sign of the infection. Or they may vomit, have a fever
and cough, appear restless or tired and without energy, or have difficulty breathing and eating.
See your doctor if you have difficulty breathing, chest pain, persistent fever of 102 F (39 C) or
higher, or persistent cough, especially if you're coughing up pus.
It's especially important that people in these high-risk groups see a doctor:
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