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BMLS-3J
Edward Jenner
Late 18th century
Cowpox= Vaccinia virus
Vacca is Latin for cow
Hence vaccination
APURA, Jake Angelo T.
BMLS-3J
25 sheep 25 sheep
Vaccine No Vaccine
Anthrax virus Anthrax virus
Perfect health Died
Louis Pasteur
Pasteur produced the first vaccine
for rabies by growing the virus in
rabbits, and then weakening it by
drying the affected nerve tissue.
On July 4, 1886, 9-year-old Joseph
Meister was bitten repeatedly by a
rabid dog
Pasteur treated him with his
attenuated rabies vaccine two days
later. Meister survived.
Difference between Jenners and Pasteurs
concepts on immunity
Louis Pasteur
Attenuation
Change in the virulence of a
pathogenic microorganism
(weakened but viable strain)
Induced by passage through another
host species
Decreased virulence for the native
host
APURA, Jake Angelo T.
BMLS-3J
Cells Plasma
TB healthy guinea pigs
Kochs Phenomenon
4. War of the Cells and Antibodies
A. Cellular Theory:
Elie Metchnikoff
Robert Koch
B. Humoral Theory:
Paul Ehrlich
Behring & Kitasato
A. Cellular Theory: Ellie Metchnikoff
Metchnikoff discovered that the
transparent starfish larva B. Humoral Theory:
contained cells that could Paul Ehrlich
efficiently surround and ingest Showed serum from immunized
foreign material, including animals kills bacteria
microorganisms. Subsequent Behring & Kitasato
experiments indicated that similar
APURA, Jake Angelo T.
BMLS-3J
Scientist Discovery
Bordet Complement
system
Salk, Sabin Polio vaccine
Reed Yellow fever
vaccine
Frazer Human
papillomavirus
vaccine
Burnet Clonal selection
theory