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Anticancer Therapy
Presented by-
Diksha Kumari
Anurag Chanda
Anindita Biswas
B.pharm ,4thyr,7th Semester
Guru Nanak Institute of Pharmaceutical Science and Technology
Introduction 1
Chemoradiation-
Conventional anticancer therapies target p53 because almost all genotoxic anticancer drugs as
well as ionizing radiation (IR) cause the substantial DNA damage, which triggers p53 activation and
stabilization. Early preclinical studies using both in vitro cell and in vivo tumor models showed that
cells or tumors with a wt p53 are more sensitive to chemoradiation.
Conclusion-
However, restoring endogenous p53 function holds a lot of promise. Research has been
done to show that this restoration can lead to regression of certain cancer cells without
damaging other cells in the process.
Thus as the old proverb goes prevention is the best medicine. Chemoprevention is a
widely accepted concept, aiming to kill cancer prone cells at the early stage of
carcinogenesis to prevent tumor formation in the first place. Nontoxic natural products
from vegetables, teas, and fruits as chemoprevention agents have been extensively
studied, and some promising components have been advanced to clinical trials
Thank you
Reference-
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[5.] Hock AK et al(2011). "Regulation of p53 stability and function by the deubiquitinating enzyme
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