Professional Documents
Culture Documents
Revision Notes
Antigen
An antigen is a substance that stimulates the production of an antibody when it gets into the body.
Antigens are often chemicals on the surface of a cell such as proteins, glycoproteins or
carbohydrates. They can also be toxins made by bacteria, or sometime are whole microorganisms
such as bacteria or viruses.
Macrophage
Macrophages function in both non-specific defence as well as help initiate specific defence
mechanisms. Their role is to engulf and digest cellular debris and pathogens, either as stationary or
mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens.
They are specialised phagocytic cells that attack foreign substances, infectious microbes and cancer
cells through destruction and ingestion.
Antigen-presenting cell
An antigen-presenting cell or accessory cell is a cell that displays foreign antigen complexes with
major histocompatibility complex (MHC) on their surfaces. T-cells may recognise these complexes
using their T-cell receptors. These cells process antigens and present them to T-cells.
Antibodies
When the body is exposed to a pathogen, like a virus, the immune system creates antibodies against
the pathogen. Those antibodies stay in the blood. The next time the body is exposed to that
pathogen, the antibodies attack it before it can make us sick. When pathogens arrive, the immune
system activates antibodies to deal with the invader.