SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 18.10.2010

1. Identification of the substance/mixture and of the company/undertaking

Product Information
Catalogue No.: 107233
Product name: Phenolphthalein indicator ACS,Reag. Ph Eur
Use of the Reagent for analysis
Substance/Mixture

Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Emergency telephone Please contact the regional Merck representation in your country.
number:
Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de

2. Hazards identification
GHS Classification
Carcinogenicity, Category 1B H350: May cause cancer.
Germ cell mutagenicity, Category 2 H341: Suspected of causing genetic defects.
Reproductive toxicity, Category 2 H361f: Suspected of damaging fertility.
EC Classification
Carc.Cat.2; R45
Mut.Cat.3; R68
Repr.Cat.3; R62
For the full text of the R-phrases mentioned in this Section, see Section 16.

3. Composition/information on ingredients
Formula C₂₀H₁₄O₄ (Hill)
CAS-No. 77-09-8
Index-No. 604-076-00-1
EC-No. 201-004-7
Molar mass 318,32 g/mol

4. First aid measures

After inhalation: fresh air. Call in physician.

After skin contact: wash off with plenty of water. Remove contaminated clothing. Consult a
physician.
After eye contact: rinse out with plenty of water. Call in ophthalmologist.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 1 of 8
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

5. Fire-fighting measures

Suitable extinguishing media

Water, Carbon dioxide (CO2), Foam, Dry powder
Specific hazards during fire fighting
Combustible material
Development of hazardous combustion gases or vapours possible in the event of fire.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.

6. Accidental release measures

Personal precautions
Avoid substance contact. Avoid inhalation of dusts. Ensure adequate ventilation.
Environmental precautions
Do not empty into drains.
Methods for cleaning up
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

7. Handling and storage

Handling
Advice on safe handling
Work under hood. Do not inhale substance.
Observe label precautions.

Storage
Further information on storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorised persons.
Storage temperature: no restrictions.

8. Exposure controls/personal protection

Personal protective equipment

Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
Hand protection
full contact:
The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

Glove material: Nitrile rubber

Glove thickness: 0,11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0,11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Eye protection
Safety glasses
Protective measures
protective clothing
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.

9. Physical and chemical properties

Form solid

Colour white

Odour odourless

pH no data available

Viscosity, dynamic no data available

Melting point 263,7 °C

Method: OECD Test Guideline 102

Boiling point/boiling range > 450 °C

Method: OECD Test Guideline 103

Ignition temperature not combustible

Flash point not applicable

Flammability The product is not flammable.

Flammability (solids)

NF T 20-042

Lower explosion limit no data available

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

Upper explosion limit no data available

Vapour pressure < 0,00001 Pa

at 50 °C
Method: OECD Test Guideline 104

Relative vapour density no data available

Density 1,296 g/cm³

at 20 °C
Method: OECD Test Guideline 109

Bulk density 350 - 450 kg/m³

Solubility/qualitative no data available

Water solubility 3,36 mg/l

at 20 °C
Method: OECD Test Guideline 105

Particle size Mean particle size

56,6 µm
Method: OECD Test Guideline 110

Partition coefficient: n- log Pow: 0,9

octanol/water Method: OECD Test Guideline 107
Bioaccumulation is not expected (log Pow <1).
Auto-flammability 397 °CMethod: NF T 20-036

Evaporation rate no data available

Oxidizing properties no data available

10. Stability and reactivity

Conditions to avoid
no information available
Materials to avoid
Violent reactions possible with:
Strong oxidizing agents
Hazardous decomposition products
no information available
Further information
The following applies in general to flammable organic substances and preparations: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.

11. Toxicological information

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

Skin irritation
Result: irritating
Method: OECD Test Guideline 431
Eye irritation
Result: negative
Method: OECD Test Guideline 437
Sensitisation
Sensitisation test: mouse
Result: negative
Method: OECD Test Guideline 429

Genotoxicity in vivo
Mutagenicity (mammal cell test): micronucleus.
mouse
Result: positive
(Lit.)
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
(Lit.)
Mutagenicity (mammal cell test): chromosome aberration.
Result: positive
(Lit.)
CMR effects
Carcinogenicity:
May cause cancer.
Mutagenicity:
Suspected of causing genetic defects.
Reproductive toxicity:
Suspected of damaging fertility.

Further information
Quantitative data on the toxicity of this product are not available.
Further toxicological data:
After uptake of large quantities:
Nausea, Vomiting, Gastrointestinal disturbance, Fever, cardiovascular disorders, CNS disorders
The substance has a laxative effect.
Further data:
This substance should be handled with particular care.

12. Ecological information

Ecotoxicity
Toxicity to daphnia and other aquatic invertebrates.
EC50
Species: Daphnia magna (Water flea)
Dose: > 4,34 mg/l
Exposure time: 48 h
Method: OECD Test Guideline 202

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 5 of 8
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

Toxicity to algae
Growth inhibition EbC50
Species: Desmodesmus subspicatus (green algae)
Dose: 2,5 mg/l
Exposure time: 72 h
Method: OECD Test Guideline 201

Growth inhibition ErC50

Species: Desmodesmus subspicatus (green algae)
Dose: > 3,33 mg/l
Exposure time: 72 h
Method: OECD Test Guideline 201

Growth inhibition NOEC

Species: Desmodesmus subspicatus (green algae)
Dose: 0,57 mg/l
Exposure time: 72 h
Method: OECD Test Guideline 201

Mobility
Surface tension
71,8 mN/m
at 20 °C
Method: OECD Test Guideline 115

Partition coefficient: n-octanol/water

log Pow: 0,9
Method: OECD Test Guideline 107
Bioaccumulation is not expected (log Pow <1).
Additional ecological information
Do not allow to run into surface waters, wastewater, or soil.

13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.com you will find country- and substance-specific information as well as
contact partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.com you
will find special information on the respective national conditions as well as contact partners.

14. Transport information

Not classified as dangerous in the meaning of transport regulations.

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 6 of 8
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

15. Regulatory information

GHS-Labelling
Hazard pictograms

Signal word
Danger

Hazard statements
H350: May cause cancer.
H341: Suspected of causing genetic defects.
H361f: Suspected of damaging fertility.

Precautionary statements
P201: Obtain special instructions before use.
P281: Use personal protective equipment as required.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.

Restricted to professional users.

Index-No. 604-076-00-1
Labelling according to EC Directives
Symbol(s): T Toxic

R-phrase(s): 45-62-68 May cause cancer. Possible risk of impaired fertility.

Possible risk of irreversible effects.
S-phrase(s): 53-45 Avoid exposure - obtain special instructions before use.
In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
EC-No. 201-004-7 EC Label

National legislation
Storage class VCI: 6.1A Combustible substances, toxic
Major Accident Hazard 96/82/EC Update:
Legislation: Directive 96/82/EC does not apply

Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

16. Other information

Full text of R-phrases referred to under sections 2 and 3
R45 May cause cancer.
R62 Possible risk of impaired fertility.
R68 Possible risk of irreversible effects.

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 7 of 8
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107233

Product name: Phenolphthalein indicator ACS,Reag. Ph Eur

Regional representation: This information is given on the authorised Safety Data Sheet for
your country.

The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
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