Professional Documents
Culture Documents
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CHAPTER-7
3. Drug: Drugs are chemical substances other than food, which when introduced
into the body, modify the body functions by producing interaction with the living cellular
elements and hence are used to diagnose, or to prevent or to control, or to cure a disease.
Drug Medicine
a. Drugs are active substances used to modify a. Medicines are finished products, which
physiological systems or, pathological states contain drugs in active form as well as the
for the benefit of the recipient. recipient.
b. Are with the generic name. b. Are with the brand, or trade name.
c. Do not have suitable forms and doses. c. Have suitable forms and doses.
d. Used to diagnose or to prevent or to control d. Used mainly for the treatment of a disease.
or to cure a disease. e. All medicines are drugs.
e. All drugs are not medicine.
a. Indication
(1) Headache.
(2) Toothache.
(3) Arthralgia
(4) Myalgia.
(5) Dysmenorrhoea.
(6) Fever etc.
b. Contraindication:
(1) Hemophilia.
(2) Gastro-intestinal ulceration or lesions.
(3) Infants under 1 year.
c. Side effects: Gastro-intestinal irritation with slight asymtomatic blood loss,
increased bleeding time, bronchospasm and skin reactions in hypersensitive patients. Prolonged
administration gives rise to hearing disturbances such as tinnitus.
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d. Dose: Adult:- 300 mg to 900 mg, 4-6 hourly when necessary (usually
after meal) daily.
a. Indication:
b. Contraindications:
(1) Drowsiness.
(2) Dryness of mouth.
(3) Gastro-intestinal disturbances.
a. Indications
(1) Hyperacidity
(2) Gastric ulcer.
(3) Duodenal ulcer.
(4) Gastritis.
(5) Heart burn.
(6) Dyspepsia.
b. Contraindication: Hypophosphataemia : if simethicone is added, contra-
indicate in renal failure, severely debilitated patient.
d. Dose: 1-2 tabs chewed half to 1 hour after meals 3 times or 4 times daily.
a. Indications:
b. Contraindications:
(1) Glucoma.
(2) Pyloric stenosis.
(3) Prostatic enlargement.
(4) Intestinal obstruction.
(5) Paralytic ileus.
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c. Side effects: Dry mouth with difficulty in swallowing & thirst, dilatation
of pupils with loss of accommodation & sensitivity to light.
5. METOCLOPRAMIDE (MOTILON)
a. Indication:
b. Contraindication:
(1) Drowsiness.
(2) Constipation.
(3) Extra pyramidal affect (specially in children)
6. DEXAMETHASONE (ORADEXON)
a. Indication:
c. Contraindication:
(2) Psychosis.
(3) Renal dysfunction.
(4) Diabetes mellitus.
(5) Glucoma.
(6) Hypertension.
(7) Congestive heart failure.
(8) Tuberculosis.
(9) Local or systemic infections unless controlled by chemotherapy.
7. AMINOPHYLLINE
a. Indication:
(a) Asthma.
(b) Emphysema
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(c) Chronic bronchitis
(2) Left ventricular failure.
(3) Cardiac asthma.
b. Side effect:
(1) Tachycardia
(2) Palpitations.
(3) Nausea.
(4) Cardiac arrhythmias and convulsions specially if given rapidly by I.V
injection.
c. Dose:
(1) By mouth: Adult initially 100-300 mg bid for one week, then
maintenance dose of 200-600 mg bid.
8. HYDROCORTISONE
a. Indication:
b Contraindication:
(1) Tuberculosis.
(2) Active peptic ulcer.
(3) Psychosis.
(4) Renal dysfunctions.
(5) Diabetes mellitus.
(6) Glucoma.
(7) Hypertension.
(8) Congestive heart failure.
(9) Pregnancy.
c. Side effects:
(1) Hypertension
(2) Sodium retention
(3) Potassium loss.
(4) Muscle weakness.
(5) Diabetes.
(6) Osteoporosis (particularly in elderly).
(7) Mental disturbances.
(8) Euphoria is frequently observed.
(9) Peptic ulceration which may result in haemorrhage or perforation.
(10) Suppression of growth (in children).
(11) Spread of infections.
(12) Adrenal suppression.
(13) Menstrual irregularities.
(14) Overdoses may cause Cushing’s syndrome with moon face, striae and
acne.
a. Indication:
b. Contraindication
(1) Glucoma.
(2) Prostatic enlargement.
(3) Intestinal obstruction.
(4) Pyloric stenosis.
(5) Paralytic ileus.
c. Side effects:
10. ADRENALINE
a. Indication:
(1) Bronchospasm.
(2) Chronic bronchitis
(3) Emergency treatment of acute anaphylaxis.
b. Contraindication:
(1) Hyperthyroidism.
(2) Hypertension.
(3) Coronary disease.
c. Side effects:
(1) Anxiety.
(2) Tremor.
(3) Tachycardia.
(4) Cardiac arrhythmias.
(5) Cardiac disease.
(6) Diabetes should not be used within 2 wks of MAO inhibitors not to be
given intravenously because of increased risk of cardiac irregularities.
d. Dosage:
Bronchospasm: As a single dose by S C or I M or oral inhalation of nebulised
solution 200-500 mcg by aerosol inhalation by S C or I M injection 0.5-1 mg daily.
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11. FRUSEMIDE ( lasix)
a. Indication:
b. Contraindication:
c. Side effect:
(1) Rashes.
(2) Tinitus and
(3) Deafness in impaired renal function.
d. Dosage
Adult: By mouth, 20-80 mg once or twice daily by I.M or I.V (slow) injection 20-40-
mg.
a. Indication:
(1) Amoebic.
(2) Liver abscess.
(3) Giardiasis.
(4) Trichomonal vaginitis.
(5) Ulcerative stomatitis and.
(6) Amoebic infections of other organs.
b. Contraindication:
c. Side effect:
(1) Nausea.
(2) Headache.
(3) Drowsiness.
(4) Dizziness.
(5) Rashes.
(6) Metallic taste etc.
b. Contraindication:
c. Side effect:
b. Contraindication:
(1) Pregnancy.
(2) Infants under 6 weeks.
(3) Renal and hepatic failure.
(4) Jaundice and blood disorder.
c. Side effect:
(1) Nausea.
(2) Vomiting.
(3) Skin rash.
(4) Eosinophilia.
(5) Agranulocytosis.
(6) Leukopenia & Megaloblastic anaemia due to trimethoprim.
a. Indication:
(1) UTI.
(2) Respiratory tract infection.
(3) Infection of ear.
(4) Infection of nose.
(5) Infection of throat.
(6) Infection of eye.
(7) Infection of skin & soft tissue.
(8) Infection of bone, joints.
(9) Infection of G.I tract.
(10) Gonorrhoea etc.
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b. Contraindication:
a. Indication:
(2) As antipyretic.
(a) Fever,
(b) Rheumatic fever.
b. Contraindication:
(1) Hemophilia.
(2) Gastro-intestinal ulceration or lesions.
(3) Infants under 1 year.
a. Indication:
(1) Anxiety.
(2) Insomnia
(3) Night terrors in children.
(4) Adjunctive treatment of acute alcohol withdrawal.
(5) Epilepsy and other convulsion.
b. Contraindication:
c. Side effects:
(1) Drowsiness.
(2) Dizziness.
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(3) Ataxia (particularly in elderly) occasionally confusion.
(4) Dry mouth.
(5) Respiratory depression of i.v. Inj. pain & thrombophlebitis.
(6) Neuromuscular disorders.
(7) Closed angle glaucoma.
(8) Respiratory disease.
(9) Late pregnancy.
(10) Nursing mothers.
(11) Reduce dosages in elderly & debiliated patients.
(12) Liver disease.
(13) Renal impairment.
(14) Patient’s ability to avoid alcohol & other CNS depressants.
(15) Avoid abrupt withdrawal.
a. Indication
(1) Nausea.
(2) Vomiting.
(3) Vertigo.
(4) Migraine.
(5) Labyrinthine disorders
(6) Minor mental and emotional disturbances.
b. Contraindication
18. RANITIDINE: Ranitidine is the drugs which reduces acid secretion by blocking
the H2-Receptors in the gastric parietal cells.
a. Indication
(1) Headache.
(2) Dizziness.
(3) Nausea.
(4) Skin rashes and itching (Rarely) and
(5) Diarrhoea may occur.
c. Dose: Oral:-Tablet-150 mg twice daily or 300 mg at bed time for 6-8 weeks,
Parenteral:- I.V or I.M 50 mg 6-8 hourly.
a. Indication
b. Contraindication
c. Side effects:
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(11) Facial flushing.
(12) Vertigo.
(13) Bradycardia.
(14) Palpitation.
(15) Postural hypotension.
(16) Hypothermia.
(17) Hallucination.
(18) Mode change.
(19) Miosis.
(20) Urticaria.
(21) Pruritus
a. Indication
(1) As an analgesic in
(a) Labour.
(b) Renal colic.
(c) Minor surgery.
(d) Ophthalmology.
(e) Dentistry.
(2) Pre-anaesthetic medication.
(3) Maintenance of general anesthesia.
(4) Relief of spasm of :
(a) GIT.
(b) Uterus.
(c) Urinary bladder.
b. Contraindication
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ROUTES OF ADMINISTRATION OF DRUGS WITH EXAMPLE
1. The main routes of administration of drugs are as follows:-
a. Systemic routes
(1) Enteral routes
(a) Oral routes: Ampicilline, Aspirin
(b) Buccal routes: Thymol glycerin
(c) Sublingual routes: Nitroglycerin
(d) Rectal routes: Bisacodyle, Mono-chlor-carbacol
(2) Parenteral routes
(a) Injection
i. Intradermal/Intracutaneous routes: B C G -Vaccine
ii. Subcutaneous routes: Insulin, Adrenalin
iii. Intermuscular routes : Benzyle penicilline
iv. Intra veineous routes: Aminophylline, blood
v. Intra arterial routes: Floxuridine,Tolazoline.
vi. Intra-thecal routes: Methotrexate, Epidural.
vii. Intra- cardiac routes: Adrenalin, Steroid.
viii. Intra peritoneal routes: Cytotoxic drugs
ix. Intra-articular routes: Corticosteroids.
(b) Inhalation.
i. General anaesthesia
ii. Sulbutamol
iii. Addrenalin.
b. Local routes
(1) Topical routes:
(a) Skin: Scopolamine
(b) Eye: Chloramphenicol
(c) Ear: Neomycin 0.5%
(d) Nose: Xylomatazoline 0.1%
(2) Iontophoresis.
Advantages Disadvantages
a. Self medication is possible a. Large volume of drug is difficult to
b. It is a safe and simple route. administer.
c. Drug effect is sustained and uniform due to b. Infection, irritation or necrosis to the site of
slower absorption. injection may occur.
c. Discoloration of the skin may occur.
Advantages Disadvantages
a. Drug effect is rapid and reliable. a. In is a painful route.
b. Moderate volume of drug (not>5ml) can be b. Self medication is not possible.
administered. c. Local inflammation, infection, irritation,
c. Slight irritant drugs can be administered. hematoma formation, etc. or nerve injury may
d. Suitable for depot preparations (e.g. occur.
medroxy progesterone) d. Not-suitable for administration of large
e. First pass metabolism can be by passed. volume of drug.
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Advantages Disadvantages
a. Rapid onset of drug action, hence it is a. Strict aseptic measure is necessary.
termed the route of emergency. b. Self medication is not possible.
b. Bio-availability is 100% c. Increased risk of adverse effects.
c. Suitable for administration of large volume d. Extravasations, air-embolism, thrombosis,
of drug. inflammation, abscess etc. may occur.
d. Irritant, unpleasant drug or hypertonic e. Not suitable for oily solution, or insoluble
solution can be given. and solid substances.
e. First pass metabolism of drugs can be by f. Should be administered slowly and
passed. carefully.
f. Suitable for unconscious patients and g. Duration of drug action is short due to
vomiting or diarrhea cases. rapid excretion.
g. Drug administration can be stopped, if
adverse effect develops.
Advantages Disadvantages
a. Rapid onset of drug action, due to a. Dose regulation of the drug is difficult.
immediate absorption. b. Pulmonary epithelium may be irritated.
b. Local desired site of action. c. It is a difficult method of drug
c. First pass metabolism is by-passed. administration.
Advantages Disadvantages
a. Drug absorption is quick and reliable so a. Larger dose of drug can not be
onset of action is rapid. administered.
b. No chance of destruction by gastric juice. b. Lipid insoluble drugs can not be
c. First pass metabolism is by-passed. administered.
d. Excess drug can be spitted out. c. Not suitable for irritant drugs.
e. It is a simple and painless route. d. Inconvenient for unconscious or non co-
operative patients.
4. RECTAL ROUTE
a. Advantages
b. Disadvantages:
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INDENT
1. Definition It is an order form for medical stores items. (Drugs, Chemicals, Gases,
Equipment &Appliances).
2. Types of indent: The following are the main categories of indents in use in the
Armed forces Hospital and other institutions:
a. It is very essential that the all indents should be carefully prepared and submitted
in due time. Incorrect indents and delay in submission will not only cause inconvenience
to the depot but also delay supplies to other units as the allotment have to be worked out
on Armed Forces basis.
b. The following points must to be kept in mind during the preparation of indents:
(1) PVMS book must be carefully studied and kept amended up-to date.
(2) BAFM-1216 (indent form) small or large should be carefully filled in
c. The following columns required attention:
(1) Name of the indenting unit and its address.
(2) Number, date and classification of the indent.
(3) Authority Government letter or MME scale.
(4) Name of the nearest railway station.
d. Separate sheet should be used for each section of the PVMS. Each sheet must
show the name of the unit its address, the indent number and date.
e. All the columns of the body of the forms also need to be filled in carefully and
demands calculated correctly.
(1) PVMS no. and correct nomenclature should be entered in columns 2 and
3.
(2) Accounting unit should also be mentioned.
(3) Quantity in stock and average monthly consumption (Columns 5 and 6
should be filled in with the figures actually taken from the ledgers and averages
worked out correctly).
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(4) Filling of columns 7 (Quarterly demand) needs maximums care. Figures in
columns 6 (Average monthly consumption) should be multiplied by 6 and the
quantity in stock (Columns-5) should be deducted from the product. This gives
the quantity required, and should, however, in no case exceed 3 times of the
average monthly consumption. If the indent for the current quarter has not yet
materialized and is probably in transit, the average monthly consumption should
then be multiplied by the figure ‘3’ and not 6 and the quantity of stock in column
5 to be deducted.
1. Occasions for sampling: Under the following circumstances the drug will be sent to the
AFF & DL for analysis and report.
a. On the expiry of the life of a drug.
b. The turn over period.
c. On apparent change in physical characters.
d. On occurrence of toxic reactions.
2. The following precautions in sending the samples are very important and must invariably
be followed.
a. The quantity required for test and analysis to any sample is given in annex ‘B’ The
samples as far as possible be sent in original containers.
4. Procedures of sampling
(a) It is necessary that sampling should be carried out by batch number and samples
drawn in the clean dry containers preferably in glass bottles.
(b) In the case of drugs which decompose rapidly on exposure such as Hydrogen
peroxide, liq Ammonia fortis etc is desirable to send the original sealed bottles/
tins as received.
(c) The quantity sent for test will be charged off the ledger by the sender at his end on
receipt of a certificate from the AFF & DL that the sample has been expended in
test. Regular issue vouchers on this account will not be entertained by the COAFF
&DL.
(d) The samples will be sent on the proforma giving in appx ‘C’.
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5. Proforma for samples of med stores for testing & analysis
a Designation of Officer sending samples
b. Postal address.
c. Proforma number.
Name of Manufacturer
Type of Package
Date of receipt
Qty in stock
PVMS No
Batch No
Remarks
DOM
DOE
S.No
A/U
(a) (b) (c) (d) (e) (f) (g) (h) (i) (j) (k) (l) (m) (n) (O)
(a) The test reports are to be sent to the units with copies to DGMS, DMS by AFF
&DL
(b) AFMSD checks own stocks and segregate the items affected by the unfavorable
reports. The total stocks are then intimated to the DGMS who may also call for similar
information from all the units.
7. Check tests and disposal of stock: When the stock is large, check test will be done
on confirmation of deterioration or toxicity. Aboard of survey on the authority of test report will
give disposal
8. Important precautions: The commanding officer of the unit will ensure.
a. Batch numbers and dates quoted on complaints, test requested and stock returns
are correct.
b. That the toxic reactions are due to the drug and not to faulty technique in
administration.
c. The stock condemned is destroyed in the persence of the board with out waiting
far the approval by the DMS/ ADMS
1. It requires a BLR (Beyond Local Repair) class v certificate from EME work shop to hold
a survey board. After getting the BLR class v certificate permission to be taken from
DGMS.
2. After obtaining permission from DGMS a survey board to be constituted by CTM which
comprises one president and two members (Concerning specialist, a field officer and
EME representative) the senior most officer will be the president.
3. On the day of survey the unserviceable equipment is to be shown to the board with all
supporting documents. Signature to be taken by the members and president of the board
on all the five copies of AFA-2 which are prepared earlier.
4. Proceeding of survey boards to be countersigned by CO of the hospital.
5. After that four copies are to be sent to DGMS via NHQ (DMS) for approval by DGMS
and one copy to be kept in the office for records.
6. After approval one copy is kept in the DGMS office, one copy to be sent to AFMSD and
remaining two copies to be dispatched to NHQ to sent it to individual unit NHQ will keep
one copy as office copy and one copy will be dispatched to individual unit.
7. After receiving the approval copy by the unit, the items to be charged off vide DGMS
letter no and the item to be sent to AFMSD on regular issue voucher with a copy of
survey board proceeding. All necessary documents (log book, catalog, BLR certificate) a
representative also to be sent to AFMSD to hand over the items.
8. The unit will raise a replacement indent to get the replacement of surveyed items.
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2. For the survey of X-ray and Electromedical equipments the board will be constituted by
the AFMSD/ DMS and in case of checking the receipt stores by the CO of the unit. The board
proceeding will be approved by the concerning authority.
1. The followings are the occasions when survey board will be held.
a. Routine quarterly survey board- To check the fitness of drugs and serviceability
of the equipments.
b. To check the all consignments received from AFMSD for fitness or serviceability
and to find out any discrepancy.
c. To survey all the surplus stores so declared by the OI/C Medical stores before
their final disposal.
d. To assess the condition of any equipment before sending it for repair or to the
salvage depot.
e. On disbanding of a unit.
f. Before handing or taking over of Medical stores or when considered necessary by
the commanding officer of the unit.
1. Stock solutions and chemicals should be stored in a separate room away from sensitive
materials, a cool, dry, well ventilated room chosen for the purpose.
2. If solid chemicals are stored in sealed tins. Them it will remain fresh at temperature
between 0-430 C. Some chemicals will absorb moisture whilst others are known to give
up water content so that chemicals not stored in sealed tins are often unreliable because
there dry chemical content is in determinate.
3. Liquids must be stored away from the effects of heat or extreme cold and should never be
kept upon shelves near a window.
4. Solutions should be put into well stoppered bottles. Developer which is to be kept for
some time should be filled in the bottle right up to the cork and a little wax run round the
injection of the bottle neck and the cork to form an airtight seal.
1. The turn over period: Turn over means that the old stocks which are likely to
become time expired and thus unfit for use must be consumed forth with and to be replaced by
fresh stocks. Items which are required to be stored for a considerable time e.g. the reserve
medical stores must be turned after a specified period.
1. Antibiotics
a. All types of antibiotics should be stored in the dry state in sterile containers and at
a temperature not exceeding 150 C in a dry place. The stability of the antibiotics is closely
related to their moisture. Contents with crystalline forms containing less then 0.5 percent
of moisture retain their potency even at room temperature for two to three years.
Solutions, creams etc are deteriorated much more rapidly specially above 400 C and at
room temperature the loss of potency is considerable within 24 hours
b. Both the crystalline substance and its solutions are remarkably stable and may be
stored at room temperature.
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2. Volatile drugs: All these substances including volatile anesthetics should be stored
in cool storage. The facilities are not available; they may be kept in a dark dry and cool
place. The highly inflammable one should be stored in an isolated building under
adequate fire precautions.
3. Acid and alkalis Should be stored separately in glass containers. These should not
be allowed to come in contact with the body clothes.
4. Rubber Articles They should be kept in inflated condition, properly powdered with
chalk/talcum powder and to be kept in well ventilated place. They should be frequently
turned over.
5. Grouping Sera All blood grouping sera should be stored between 4-60 C
6. Blood infusion sets: ACD/CPD bags of 450 ml capacity including 63 ml
Anticoagulant are used now a day. These sets are supplied by the AFMSD. Blood
collected in ACD and CPD bags can be kept for 21 and 28 days respectively at 4-60 C
1. Local purchase of medical stores and spares of electro medical equipment has been
authorized in order to meet the urgent and life saving demands of consumer units and will
be done by the CO unit
2. Funds for local purchase
DGMS place funds at the disposal of units. Only life saving items of medical store
prescribed by concerned specialist and not available will be purchased locally
OINTMENT
1. Definition An ointment is a semisolid preparation containing some active ingredients
containing fatty base, intended for external application with or without rubbing e.g. sulphar
ointment.
2. Active ingradient:
a. Sulphur.
b. Salicylic acid.
c. Benzoic acid etc.
3. Base:
a. Soft paraffin.
b. Wool fat.
c. Soft fat etc.
4. Preparation
a. Ung white field
(1) Acid salicylic-15 gr
(2) Acid benzioc-25 gr
(3) Soff jparaffin-01 OZ
(1) Sulphur-45 gr
(2) Vaselin-01 Oz
(1) Sulphur-6.25 gm
(2) Zinc Oxide-37.5 gm
(3) Resorcinal-6.25 gm
(4) Emulsifying oint 50 gm
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DROP
1. Definition Drop is sterile fluid preparation containing one or more active ingredient
which is used into the eye, nose and ears e.g. Betnosol N eye drop
(1) Chloramphenical-500 mg
(2) Dist. Water-100 ml
1. Receive:
a. All items of medical stores and equipment’s are to be received from Armed
Forces Medical Store Depot through proper authority.
b. The items which are not supplied from AFMSD are to collect from local market
as local purchase medicine as advised by concern specialist.
c. Received from various Naval ships and established as short life and slow moving
items.
2. Issue: There are mainly two ways of medical stores issue such as.
3. Storage:
a. Stock of any medicine for future use. Various drugs are stored in different
condition according to its properties and use. The drug should be stored according to the
size of the container for quick supply disposal.
b. Stock on shelves in the store should be kept away from floor, wall and ceiling.
The lowest shelf should be at best 1 ft from floor and highest not less than 3 fit from
ceiling, but the height should be convenient for easy access. The distance between the
stacks and walls should be not less then 3 ft and stacking against the walls should not be
done. A distance of about 3 ft should be left between the stacks.
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c. Keep the store clean and free from dust which contains numerous spores and
living organisms causing infestation of the stores should be avoided as for as possible.
d. Bottles, tins, packages etc are best stored in shelves, Ampoules and other such
small containers may be kept in a series of metal trays which should be labeled and
numbered and placed in shelves like other containers in a cub board. Each item should be
carefully numbered and labeled.
e. Storage of antibiotics: All types should be stored in the dry state in sterile
containers and at a temperature not exceeding 150 C in a dry place. The stability of the
antibiotics is closely related to their moisture content. Crystalline forms containing less
than 0.5 percent of moisture retain their potency even of room temperature for two to
three years.
f. Syrup: Syrup should be kept in a separated room in cool and dry place.
l. Medical gas cylinder: Cylinders should be stored are separate room keet dry and
clean and well ventilated places.
2. Measurement of fluid: Two systems are employed in pharmacy ig. The imperial
and the metric systems to measure the volume of fluid.
a. Metric system of capacities: 1 litre is the volume of 1 kilogram of water under
stated conditions.
a. weight
b. Volume
15 minims 1 cc (1 ml)
1 fluid ounce 30 cc
1 fluid drachm 4cc
1 pint 570 cc
1 ¾ pints 1 litre
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