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TRIS NITRO
TRIS(HYDROXYMETHYL)NITROMETHANE*
®
Low Toxicity
Product Advantages The Oral LD50 for TRIS NITRO solid in rats is 1875 mg/kg.
Under the requirements of the Federal Hazardous
Long Lasting Odor Control Substances Act, formulations with an oral LD50 of greater
than 5000 mg/kg may be classifiable as nontoxic. The
The primary function of chemical toilet deodorizers is odor LD50 of a 25% solution of TRIS NITRO is on the order of
control. When properly formulated, TRIS NITRO will 7500 mg/kg. However, because of the possibility of
provide excellent long-term odor control as compared with synergistic effects from other additives, the final
other deodorizer ingredients. formulation must be tested for toxicity to demonstrate its
safety.
Seven Day Protection in Hot, Humid Conditions
Truly effective chemical toilet deodorizers will control odor Biodegradable
for seven days in hot, humid weather. TRIS NITRO’s slow TRIS NITRO rapidly degrades in the environment which is
release mechanism provides increased deodorizer important for disposal purposes.
strength as a function of temperature and tank load.
Therefore, TRIS NITRO’s deodorizing action will be Regulatory Acceptance
available when needed most.
There is no nationally recognized standard regarding the
biodegradability of chemical toilet deodorizers. However,
TRIS NITRO has been approved for use in chemical
toilets in the State of California.
pH 6.0
The action of TRIS NITRO is based primarily on 6 Note: No decomposition at pH 4.0
pH 7.5
.0
formaldehyde release, controlled by alkalinity in aqueous
pH 9
5
solution. TRIS NITRO is soluble in water, alcohols and
glycols and can be readily incorporated into water-based 4
DAYS
pH
pH
5
of controlled formaldehyde release.
4
DAYS
Data at 40°C
Perfumes and dyes chosen for TRIS NITRO-containing 3
concentrates should be stable to formaldehyde and to pH
variations; TRIS NITRO is non-foaming and effective when 2
used with all classes of surfactants. It can also be used in
1
combination with other commonly-used active ingredients
of toilet deodorizing solutions, if desired. 0
4.0
pH 9.0
7.5
pH
pH
3
Teratology
ANGUS Chemical Company manufactures
Three groups of 25 pregnant Sprague Dawley rats were and markets a variety of products most of
dosed by gavage daily with 0, 50, 375, or 750 mg/kg/day which are derived from chemicals called
of TRIS NITRO on gestation days 6 through 15. The nitroparaffins. Using a unique chemical
females were observed at least twice daily and weighed at process, these short-chain molecules can be
appropriate intervals. On gestation day 20, the animals further processed and refined into nitroparaf-
were sacrificed, and the fetuses were weighed, sexed, fin derivatives.These and other ANGUS
examined for external, skeletal and soft tissue anomalies, products offer customers worldwide a multi-
and developmental variations. tude of performance properties
in a broad range of applications
Mortality and clinical signs of toxicity were observed at a including paints, coatings and inks,
dose level of 750 mg/kg/day. biotechnology, pharmaceutical and
agricultural intermediates, personal care
Body weight gain was severely decreased throughout the products, metalworking fluids, water treat-
entire dosing period in the high-dose group. ment and fuel systems.
ANGUS Chemical Company
A slight decrease in the mean fetal body weight was 1500 E. Lake Cook Road
apparent in litters from the high dose group. The “non- Buffalo Grove, Illinois 60089
effect” level for maternal toxicity, fetotoxicity, and Telephone: (847) 215-8600
teratogenicity was considered to be 375 mg/kg/day of Telefax: (847) 215-8626
TRIS NITRO. Place Your Order Toll Free
(800) 942-8540
Samples and Technical Assistance
Mutagenicty (800) 362-2580
TRIS NITRO was judged to be nonmutagenic in an Ames Illinois Call Collect: (847) 215-8600
Bacterial/Microsomal Assay. The study utilized Salmonella ANGUS Chemie GmbH
typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and Huyssenallee 5
TA 1538. The study was done at dosages of 0.1 to 1.0 45128 Essen
Germany
mg/plate with and without S9 liver microsomal fraction. Telephone: (49) 201-810930
Telefax: (49) 201-8109315
Similar results were obtained in a chromosome aberration Technical Assistance
study in Chinese hamster ovary (CHO) cells. Doses of FREE Telephone: 00800-22441000
0.25 to 2.5 mg/mL were utilized. No mutagenic effect for FREE Facsimile: 00800-22442000
TRIS NITRO was noted either with or without S9 liver Direct Telephone: (49) 54 59 56-0
microsomal fraction. Direct Facsimile: (49) 54 59 56267
ANGUS Chemie GmbH
Doses of 0.313 to 2.5 mg/mL were employed in the Le Bonaparte-Centre d’Affaires
unscheduled DNA synthesis assay in rat liver cell culture. Paris-Nord
93153 Le Blanc Mesnil
Analysis of prepared slides by autoradiographic technique France
demonstrated grain counts similar to the untreated control Telephone: (33) 1-48 65 73 40
for all doses. TRIS NITRO was judged to be Telefax: (33) 1-48 65 73 20
nonmutagenic in this assay. ANGUS Chemie GmbH
Unit 7, Rotunda Business Park Centre
Thorncliffe Park Estate
Chapeltown, Sheffield S30 4PH
Biodegradable England
Telephone: (44) 114-2571322
TRIS NITRO rapidly degrades in the environment which is Telefax: (44) 114-2571336
important for disposal purposes. ANGUS Chemical (Singapore) Pte. Ltd.
150 Beach Road
There is no nationally recognized standard regarding the #17-01 Gateway West
Singapore 189720
biodegradability of chemical toilet deodorizers. However, Telephone: (65) 293-1738
TRIS NITRO has been approved for use in chemical Telefax: (65) 293-3307
toilets in the State of California. ANGUS Chemical Company (Korea)
Room 910, Building “A”, Champs Elysees Center
889-5, Daechi-dong, Kangnam-ku
Seoul, Korea
Telephone: 82-2-565-0556
Telefax: 82-2-555-1488
The information and data contained herein are believed to be correct. However, we do not warrant
either expressly or by implication the accuracy thereof. In presenting uses for this product, no
attempt has been made to investigate or discuss any patent situations which may be involved.