NEUROBIOLOGY SEMINAR SERIES

Yulong Li, PhD

Peking University School of Life Sciences,
PKU-IDG/McGovern Institute for Brain Research,
Beijing, P.R. China

“Spying on in vivo neuromodulation

by constructing new GPCR-based
genetically-encoded fluorescent
sensors.”

Abstract: Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological and pathological
processes. A longstanding yet largely unmet goal is to measure DA changes reliably and specifically with high
spatiotemporal precision, particularly in animals executing complex behaviors. Here, we report the development of
genetically encoded GPCR-activation-based-DA (GRABDA) sensors that enable these measurements. GRABDA
sensors can resolve a single-electrical-stimulus-evoked DA release in mouse brain slices and detect endogenous DA
release in living flies, fish, and mice. We deploy similar strategies to develop a plethora of GRAB sensors for other
important neurotransmitters/neuromodulators.

NEUROBIOLOGY SEMINAR
**SPECIAL DATE and LOCATION**
Tuesday, January 29, 2019
12:00– 1:00 PM
Hosted By Andrew Hires
Michelson Hall, Conference Room 101
University Park Campus
1002 Childs Way Los Angeles, CA 90089
Tel. 213-740-9176
https://dornsife.usc.edu/bisc/neurobiology/