ITM2A

Integral membrane protein 2A is a protein that in

ITM2A
humans is encoded by the ITM2A gene.[5][6][7][8]
Identifiers
Aliases ITM2A, BRICD2A, E25A, integral membrane protein
Contents 2A
External MGI: 107706 HomoloGene: 31269 GeneCards: ITM2A
Function
IDs
References
Further reading Gene location (Human)

External links

Function
The protein encoded by this gene is involved in
osteo- and chondrogenic cellular differentiation Chr. X chromosome (human)[1]
(the cells which are responsible for the
development of bone and cartilage
respectively).[6]

ITM2A is also involved in activation of T-cells in Band Xq21.1 Start 79,360,384 bp[1]
the immune system[9] and in myocyte End 79,367,667 bp[1]
differentiation.[10]
Gene location (Mouse)

References
1. GRCh38: Ensembl release 89:
ENSG00000078596 (http://May2017.arc
hive.ensembl.org/Homo_sapiens/Gene/
Summary?db=core;g=ENSG000000785
96) - Ensembl, May 2017 Chr. X chromosome (mouse)[2]
2. GRCm38: Ensembl release 89:
ENSMUSG00000031239(http://May201
7.archive.ensembl.org/Mus_musculus/G
ene/Summary?db=core;g=ENSMUSG00
Band X|X D Start 107,397,099 bp[2]
000031239) - Ensembl, May 2017
3. "Human PubMed Reference:"(https://w
End 107,403,376 bp[2]
ww.ncbi.nlm.nih.gov/sites/entrez?db=ge
RNA expression pattern
ne&cmd=Link&LinkName=gene_pubme
d&from_uid=9452).
4. "Mouse PubMed Reference:"(https://ww
w.ncbi.nlm.nih.gov/sites/entrez?db=gen
e&cmd=Link&LinkName=gene_pubmed
&from_uid=16431).
5. Pittois K, Wauters J, Bossuyt P,
Deleersnijder W, Merregaert J (Mar
1999). "Genomic organization and
chromosomal localization of the Itm2a
gene". Mamm Genome. 10 (1): 54–6.
doi:10.1007/s003359900942(https://doi.
org/10.1007%2Fs003359900942).
PMID 9892734 (https://www.ncbi.nlm.ni
h.gov/pubmed/9892734).
6. Deleersnijder W, Hong G, Cortvrindt R,
Poirier C, Tylzanowski P, Pittois K, Van
Marck E, Merregaert J (Sep 1996). More reference expression data
"Isolation of markers for chondro-
osteogenic differentiation using cDNA Gene ontology
library subtraction. Molecular cloning
and characterization of a gene
Molecular • protein binding
belonging to a novel multigene family of function • amyloid-beta binding
integral membrane proteins".J Biol Cellular • membrane
Chem. 271 (32): 19475–82. component • integral component of membrane
doi:10.1074/jbc.271.32.19475(https://do
i.org/10.1074%2Fjbc.271.32.19475). • Golgi apparatus
PMID 8702637 (https://www.ncbi.nlm.ni • plasma membrane
h.gov/pubmed/8702637). • extracellular exosome
7. "Entrez Gene: ITM2A integral Biological • plasma cell differentiation
membrane protein 2A" (https://www.ncb
i.nlm.nih.gov/sites/entrez?Db=gene&Cm
process • immunoglobulin production
d=ShowDetailView&TermToSearch=945 • nervous system development
2). • negative regulation of amyloid precursor protein
8. Mao M, Fu G, Wu JS, Zhang QH, Zhou biosynthetic process
J, Kan LX, Huang QH, He KL, Gu BW, Sources:Amigo / QuickGO
Han ZG, Shen Y, Gu J, Yu YP, Xu SH,
Wang YX, Chen SJ, Chen Z (July 1998). Orthologs
"Identification of genes expressed in
Species Human Mouse
human CD34+ hematopoietic
stem/progenitor cells by expressed Entrez
9452 16431
sequence tags and efficient full-length
cDNA cloning" (https://www.ncbi.nlm.ni
h.gov/pmc/articles/PMC20949). Proc. Ensembl
ENSG00000078596 ENSMUSG00000031239
Natl. Acad. Sci. U.S.A. 95 (14): 8175–
80. doi:10.1073/pnas.95.14.8175(http
s://doi.org/10.1073%2Fpnas.95.14.817 UniProt
O43736 Q61500
5). PMC 20949 (https://www.ncbi.nlm.ni
h.gov/pmc/articles/PMC20949).
PMID 9653160 (https://www.ncbi.nlm.ni RefSeq
NM_004867 NM_008409
h.gov/pubmed/9653160). (mRNA)
NM_001171581

RefSeq
NP_001165052 NP_032435
(protein)
NP_004858

Location Chr X: 79.36 – 79.37 Mb Chr X: 107.4 – 107.4 Mb

(UCSC)
PubMed [3] [4]

search
 9. Kirchner J, Bevan MJ (July 1999). Wikidata
"Itm2a Is Induced during Thymocyte
View/Edit Human View/Edit Mouse
Selection and T Cell Activation and
Causes Downregulation of Cd8 When
Overexpressed in Cd4+Cd8+ Double
Positive Thymocytes" (https://www.ncbi.
nlm.nih.gov/pmc/articles/PMC2195576).
J. Exp. Med. 190 (2): 217–28.
doi:10.1084/jem.190.2.217(https://doi.or
g/10.1084%2Fjem.190.2.217).
PMC 2195576 (https://www.ncbi.nlm.nih.
gov/pmc/articles/PMC2195576).
PMID 10432285 (https://www.ncbi.nlm.ni
h.gov/pubmed/10432285).
10. Van den Plas D, Merregaert J (2004).
"Constitutive overexpression of the
integral membrane protein Itm2A
enhances myogenic differentiation of
C2C12 cells". Cell Biol. Int. 28 (3): 199–
207. doi:10.1016/j.cellbi.2003.11.019(ht
tps://doi.org/10.1016%2Fj.cellbi.2003.1
1.019). PMID 14984746 (https://www.nc
bi.nlm.nih.gov/pubmed/14984746).

Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a
simple method to replace the cap structure of
eukaryotic mRNAs with oligoribonucleotides".Gene.
138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8.
PMID 8125298.
Prashar Y, Weissman SM (1996). "Analysis of
differential gene expression by display of 3' end
restriction fragments of cDNAs". Proc. Natl. Acad. Sci.
U.S.A. 93 (2): 659–63. doi:10.1073/pnas.93.2.659.
PMC 40108. PMID 8570611.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al.
(1997). "Construction and characterization of a full
length-enriched and a 5'-end-enriched cDNA library".
Gene. 200 (1–2): 149–56. doi:10.1016/S0378-
1119(97)00411-3. PMID 9373149.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of
genes expressed in human CD34+ hematopoietic
stem/progenitor cells by expressed sequence tags and
efficient full-length cDNA cloning". Proc. Natl. Acad.
Sci. U.S.A. 95 (14): 8175–80.
doi:10.1073/pnas.95.14.8175. PMC 20949.
PMID 9653160.
Kirchner J, Bevan MJ (1999)."Itm2a Is Induced during
Thymocyte Selection and T Cell Activation and
Causes Downregulation of Cd8 When Overexpressed
in Cd4+Cd8+ Double Positive Thymocytes". J. Exp.
Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217.
PMC 2195576. PMID 10432285.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and
Functional Analysis of cDNAs with Open Reading
Frames for 300 Previously Undefined Genes
Expressed in CD34+ Hematopoietic Stem/Progenitor
Cells". Genome Res. 10 (10): 1546–60.
doi:10.1101/gr.140200. PMC 310934.
PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003).
"Generation and initial analysis of more than 15,000
full-length human and mouse cDNA sequences" . Proc.
Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
doi:10.1073/pnas.242603899. PMC 139241.
PMID 12477932.
Clark HF, Gurney AL, Abaya E,et al. (2003). "The
Secreted Protein Discovery Initiative (SPDI), a Large-
Scale Effort to Identify Novel Human Secreted and
Transmembrane Proteins: A Bioinformatics
Assessment". Genome Res. 13 (10): 2265–70.
doi:10.1101/gr.1293003. PMC 403697.
PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-
Length cDNA Project: The Mammalian Gene
Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:10.1101/gr.2596504. PMC 528928.
PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The
DNA sequence of the human X chromosome" . Nature.
434 (7031): 325–37. doi:10.1038/nature03440.
PMC 2665286. PMID 15772651.
External links
ITM2A+protein,+humanat the US National Library of MedicineMedical Subject Headings(MeSH)

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