I.

Aspirin Production

Process Equipment Operating Operating Other Details

Pressure Temperature
Acetylation Agitated 1 atm 88-92˚C Reaction Time: 2-3 hrs
Batch
Reactor Heating Rate Constant: 0.3 l/mol-hr
Medium:
(To be Superheated 95% Conversion of Salicylic acid
designed) steam or hot
water 20% stoichiometric excess of acetic anhydride and 10% by wt concentrated sulfuric acid
(based on the mass of salicylic acid)
Optimum
Reaction Sources:
Temperature:  https://www.chegg.com/homework-help/questions-and-answers/manufacture-
90˚C aspirin-acetylsalicylic-acid-synthesized-using-reaction-salicylic-acid-acetic--q5050378
 Chemical Reactions and Chemical Reactors by George W. Roberts
 Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
 http://eleceng.dit.ie/gavin/DT275/Module%201/Assignment.htm?fbclid=IwAR371JVkl
Raifzm6CrBiQplSw6SNVqmL3pxewgYE41J59foI72GhYUnevOo
Filtration Rotary 1 atm 90˚C
Vacuum Sources:
Drum Filter  Chemical Reactions and Chemical Reactors by George W. Roberts
Crystallization Agitated 1 atm Cooling The cooling water from the cooling tower is used to precipitate aspirin at low temperature.
Batch water: 10-
Crystallizer 25˚C Aspirin Mixture Temperature: 10˚C
Sources:
(To be  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
designed)
Centrifugation Centrifugal 1 atm 25˚C The mother liquor contains 10-20% aspirin.
Bowl/
Continuous Sources:
Centrifuge  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
 Drying Rotary 1 atm 60-70 ˚C Initial moisture content: 22% wet basis
Drum Final moisture content: 0.1% wet basis
Dryer
Source
(To be  Perry’s Chemical Engineering Handbook 8th Edition
designed)  Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr.
Extractive Distillation 1 atm Feed: 29 wt% Acetic Acid (Subcooled Liquid)
Distillation Column Distillate: 99.5 wt% Water (Saturated Liquid)
Bottoms: 99% Acetic Acid (Saturated Liquid)
(To be Reflux Ratio: 4.76
designed)
Use Ponchon-Savarit Method (Acetic Acid-Water System) to determine the number of plates
and the duties of condenser and reboiler.

Sources:
 Enthalpy- Concentration Diagram: https://www.oreilly.com/library/view/basic-
principles-and/9780132885478/app10.html
 https://pdfs.semanticscholar.org/83c0/81efacca48e7807f0318f307a8de7eb3b78c.pdf

Cooling Cooling 1 atm Process water is cooled which will be used to precipitate aspirin in the crystallizer
Tower
Source: Perry’s Chemical Engineering Handbook 8th Edition

II. Caffeine Extraction

Process Equipment Operating Operating Other Details

Pressure Temperature
III. Packaging

Process Equipment Operating Operating Other Details

Pressure Temperature
Mixing Mixing Tank 1 atm 25˚C
Sieving Vibrating Screen 1 atm 25˚C
Size Reduction Hammer Mill 1 atm 25˚C
Compression Rotary Tablet 1 atm 25˚C
Machine