Lahore University of Management Sciences

CHEM 231 – Fundamentals of Organic Chemistry

Fall 2018

Instructor Irshad Hussain

Room No. 9-519A
Office Hours TBA
Email ihussain@lums.edu.pk
Telephone 8133
Secretary/TA TBD
TA Office Hours TBA
Course URL (if any)

Course Basics
Credit Hours 03
Lecture(s) Nbr of Lec(s) Per Week 02 Duration 75 min each
Recitation (per week) Nbr of Rec (s) Per Duration
Week
Lab (if any ) per week Nbr of Session(s) Per Duration
Week
Tutorial (per week) Nbr of Tut(s) Per Duration
Week

Course Distribution
Core Biology & Chemistry majors
Elective SBASSE students
Open for Student Category
Closed for Student Category

COURSE DESCRIPTION
This course is designed to introduce organic chemistry to Biology & Chemistry sophomore students by discussing the structure and reactivity of
the major classes of organic compounds enabling the students to acquire the fundamental knowledge and skills to solve elementary problems in
organic chemistry. On completion of this course, students should have the ability to analyze simple organic reactions, predict their mechanisms
based on frontier orbitals interaction, and possible products including those that have not explicitly been discussed during the course.

COURSE PREREQUISITE(S)

• CHEM 101: Principles of Chemistry

COURSE OBJECTIVES
To enable the students to understand and predict the reactivity and mechanism of simple organic chemical reactions by
• carefully analyzing the structure of the reactants, based on their frontier orbitals interaction. At the end of this course, the
students should be able to explain simple organic reactions by identifying the interacting HOMO and LUMO of the reactants and
the type of their interaction.
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Learning Outcomes
At the end of this course, the students should be able to:
• - Clearly recognize and differentiate between the nucleophiles and the electrophiles
- Clearly recognize and differentiate the interacting frontier orbitals of the reactants and their type of interaction
- To differentiate and draw stereoisomers and conformers of different organic molecules
- To understand the effect of conformations and configurations of different organic molecules on their reactivity
- To draw mechanisms and predict products of reactions of common classes of organic compounds including those, which are
not explicitly discussed in the class.
Grading Breakup and Policy

Attendance: 5%
Assignments: 5%
Quizzes: 15 %
Mid-term exam: 35 %
Final exam: 40 %

Instructor has the privilege to change the grading scheme which, if availed, will be conveyed to the students well in time.

Examination Detail

Yes/No: Yes
Combine/Separate: Combine
Midterm
Duration: 02 h
Exam
Preferred Date: During the university mid-term exam week
Exam Specifications: Closed books, course material in any form is not permitted

Yes/No: Yes
Combine/Separate: Combine
Final Exam
Duration: 03 h
Exam Specifications: Closed books, course material in any form is not permitted
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COURSE OVERVIEW
Recommended Objectives/
Topics
Readings Application
Period 2 elements and the building blocks Course package plus recommended To know the importance of period 02
Week 1 of organic molecules sections of the textbook (s) elements and draw the building blocks of
organic molecules
Organic functional groups and their Course package plus recommended To familiarize the students with common
Week 2 stereochemistry sections of the textbook (s) organic functional groups and their
stereochemistry
Resonance and linear combination of Course package plus recommended To familiarize the students with the
Week 3 atomic orbitals (LCAO) sections of the textbook (s) concept of resonance and to build
molecular orbitals from atomic orbitals
Molecular orbital theory and frontier Course package plus recommended To familiarize the students with the
orbital theory sections of the textbook (s) molecular orbitals and understand the
Week 4
role of frontiers orbitals in organic
chemical reactions.
Conformations and cycloalkanes Course package plus recommended To familiarize the students of various
sections of the textbook (s) conformations of molecules, especially
Week 5
cycloalkanes, and understand their
reactivity based on their energy/stability.
Structure, reactivity and acid-base Course package plus recommended To familiarize students of predicting the
Week 6 equilibrium sections of the textbook (s) reactivity of organic molecules based on
their structure.
Substitution and reactions at SP3 centers Course package plus recommended To familiarize the students of SN1 and
Week 7
sections of the textbook (s) SN2reactions at SP3 carbon atoms.
Elimination reactions at SP3 centers Course package plus recommended To familiarize the students of E1 and
Week 8
sections of the textbook (s) E2reactions at SP3 carbon atoms.
Addition reactions Course package plus recommended To familiarize students with the addition
Week 9
sections of the textbook (s) reactions of unsaturated compounds.
Aromatic substitution reactions Course package plus recommended To familiarize students with the reactivity
Week 10 sections of the textbook (s) of aromatic compounds specifically the
substitution reactions.
Week 11- Addition and substitution reactions of Course package plus recommended To familiarize students with the reactivity
14 carbonyl compounds and their derivatives sections of the textbook (s) and chemistry of carbonyl compounds

Textbook(s)/Supplementary Readings
Textbooks:
Organic Chemistry by Clayden, Greeves, Warren and Wothers (Edition 2009).
ISBN 978-0-19-850346-0

Others recommended readings:

Organic Chemistry as a 2nd Language, Part – I, by David R Klein
Organic chemistry by TWG Solomons and CB Fryhle (9th Edition); ISBN 978-0-471-68496-1
Organic Chemistry by L. G. Wade Jr. (6th Edition); ISBN 0-13-147871-0