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ABSTRACT An episode of diarrhea causes weight loss and a temporary cessation of growth
in infants and children. Diarrhea is accompanied by malabsorption of sugars, nitrogen, fats, and
micronutrients. The mechanisms by which acute diarrheal disease produce malabsorption have
not been studied carefully. The nutritional costs of malabsorption may pose a major threat if
diarrhea becomes chronic or recurrent. The hydrogen breath test for carbohydrate malabsorption
does not require intubation or blood drawing and can be used in children to help clarify the
importance of carbohydrate intolerance in the duration and perpetuation of acute diarrhea and
Diarrhea may well be the commonest dis- sorption, and we will examine the possible
ease/symptom in the world. In Central mechanisms by which infectious diarrhea
America a majority of childhood deaths are may produce a transient but significant mal-
associated with diarrhea (1). Morbidity absorption syndrome. Finally, we will dis-
from diarrheal disease must be measured cuss some of the possible nutritional impli-
not only in terms of the life-threatening ef- cations of malabsorption in diarrheal dis-
fects of water and electrolyte loss, dehydra- ease.
tion, and sepsis but also in terms of the
impact on growth and nutrition in children Malabsorption of nutrients
under the age of 5. It is well documented
that an episode of acute diarrhea results in a Table 1 presents a listing of the nutrients
drop in weight and a temporary cessation of the malabsorption of which has been docu-
growth in infants and children (2). Several mented in man in association with diarrheal
factors are involved in this detrimental ef- disease or intestinal infection. The largest
fect on nutritional status of the child. These number of studies are referable to malab-
factors include withdrawal of food, shift of sorption of sugars (3-15) and fats (4, 6, 16).
food from a more nutritious diet to one of Considering that sugars represent the end
starchy gruels, the nutritional costs of infec- product of digestion of starches, the com-
tion, and the impact of diarrheal disease on monest source of dietary calories in most of
the absorption and utilization of nutrients.
We will examine the evidence for the tem- ‘From the University of Chicago Pritzker School of
porary malabsorption syndrome which oc- Medicine and the Institute of Nutrition of Central
curs in association with diarrheal disease America and Panama.
2Supported in part by the Women’s Program of the
and evaluate the scope of this problem
Gastrointestinal Research Foundation.
based on published reports. The other fac- 2Address reprint requests to: Irwin H. Rosenberg,
tors which influence the effect of infectious M.D., Professor of Medicine, University of Chicago
diarrhea on nutritional status are discussed Pritzker School of Medicine, 950 East 59th Street,
Chicago, Illinois 60637.
elsewhere.
Professor of Medicine, Head, Section of Gastroen-
We will first examine the scope of the terology, University of Chicago Pritzker School of
problem by reviewing the evidence that nu- Medicine, Chicago, Illinois 60637 5Faculty Fel-
trient malabsorption exists in acute diar- low of the Josiah Macy Jr. Foundation; holds a Future
rheal disease and the documentation of indi- Leader’s Award of the Nutrition Foundation. Univer-
sity of Chicago Pritzker School of Medicine, Chicago,
vidual nutrient malabsorption. We will ex-
Illinois 60637. 6Division de Biomedica, Institute
plore the regularity with which diarrheal dis- of Nutrition of Central America and Panama, Guata-
ease of different etiologies produces malab- mala City, Guatamala.
1248 The American Journal of Clinical Nutrition 30: AUGUST 1977, pp. 1248-1253. Printed in U.S.A.
MALABSORPTION, DIARRHEA, AND INTESTINAL INFECTIONS 1249
point of different etiologies. This table em- blood loss and iron deficit seen in hook-
phasizes the observation that whenever in- worm and schistosomal infestation.
testinal infection is sufficiently severe to
produce diarrhea, malabsorption also re- Pathogenesis of malabsorption in patients
suits. Thus, diarrheal disease and intestinal with diarrheal disease
infection associated with bacterial enteritis
(7, 20), viral enteritis (3, 5, 6), nonspecific The mechanism by which acute diarrheal
gastroenteritis (4, 7, 29), and protozoal (16, disease produces malabsorption has not
30-32) and parasitic infections (21 22, 24,
,
been studied carefully. However, the les-
25, 33-35) have all been documented to be sons learned from studies of chronic intes-
associated with malabsorption. Indeed, cer- tinal bacterial overgrowth, protein-calorie
tam systemic disorders not directly involving malnutrition, and other forms of more per-
the intestine have been shown to produce sistent intestinal mucosal damage may well
some element of malabsorption particularly, be applied to an evaluation of the mecha-
if not exclusively, when systemic infection nisms of malabsorption in acute diarrheal
results in a transient diarrheal syndrome (8, disease. The framework of possible mecha-
The bacterial mass is capable of competing effects of intestinal infection might be pro-
with the host for the uptake of ingested duced not only by bacterial toxins but also
nutrients; this phenomenon is well de- by metabolites of endogenous or exogenous
scribed in the case of vitamin B12 (45). Fur- materials.
thermore, the effects of bacterial metabo- Acute intestinal infection from a variety
lism of ingested nutrients may be important. of causes may be associated with morpho-
Bacterial fermentation of sugars occurs with logical and even villous abnormalities of the
production of gas and short-chain fatty acids intestinal mucosa similar to those associated
(46), both of which are capable of produc- with more severe chronic forms of malab-
ing gastrointestinal symptoms and increased sorption. There is often a marked loss of
water loss. Deconjugated bile acids them- absorbing surface. Such morphological ab-
selves may be irritating to the intestinal mu- normalities may reflect the toxin elabora-
cosa and may contribute to diarrhea by their tion of the offending organism, and there
own cathartic effects (47). Furthermore, may be direct invasion of the mucosa.
failure to digest and absorb sugars such as
overgrowth. Coupled with the bile salt sugar malabsorption in infantile infectious diar-
rhea. Am. J. Clin. Nutr. 25: 1248, 1972.
breath test of bacterial overgrowth (50),
12. LUCKING, T., AND R. GRUTFNER. Chronische
which can now be performed with nonradio- Diarrhoe und schweres Inalabsorptionssyndrom
active ‘3C rather than ‘4C (51), thus obviat- im Sauglingsalter nach Infektion mit Dyspepsre-
ing any hazard in infants and children, such cole. Monatsschr. Kinderheilk. 121: 376, 1973.
tests will permit assessment of the relative 13. COELLO-RAMIREZ, P., AND F. LIPSHITZ. Enteric
microflora and carbohydrate intolerance in infants
importance of carbohydrate fermentation, with diarrhea. Pediatrics 49: 233, 1972.
bacterial overgrowth, and bile salt metabo- 14. LIPSHITZ, F., P. COELLO-RAMIREZ AND G. GU-
lism in the chronicity of childhood diarrhea. TIERREZ-TOPETE. Monosaccharide intolerance and
The hydrogen breath test also promises to hypoglycemia in infantswith diarrhea. I. Clinical
course of 23 infants. J. Pediatr. 77: 595, 1970.
be useful in assessing our ability to intervene
15. LIPSHITZ, F., P. COELLO-RAMIREZ AND G. GU-
with high-calorie nutritional diets early in TIERREZ-T0PETE. Monosaccharide intolerance and
the course of childhood diarrhea before fur- hypoglycemia in infants with diarrhea. II. Meta-
ther nutritional deficit is added to that which bolic studies in 23 infants. J. Pediatr. 77: 604,
so often underlies the diarrheal episode. U 1970. *
DUPONT, R. S. NORTHRUP, R. B. HORNICK AND 23. MATOTH, Y., R. ZAMR, S. BASR-SHANI AND N.
R. M. CHANOCK. Acute infectious nonbacterial GROSSOWICZ. Studies on folic acid in infancy. II.
gastroenteritis: etiology and pathogenesis. Ann. Folic and folinic acid blood levels in infants with
Internal Med. 76: 993, 1972. diarrhea, malnutrition, and infection. Pediatrics
7. LINDENBAUM, J. Malabsorption during and after 33: 694, 1964.
recovery from acute intestinal infection. Brit. 24. SIVAKUMAR, B., AND V. REDDY. Absorption of
Med. J. 2: 326, 1965. vitamin A in children with ascariasis. J. Trop.
8. COOK, G. C. Glucose absorption kinetics in Zam- Med. Hyg. 78: 114, 1975.
bian African patients with and without systemic 25. SIVAKUMAR, B., AND V. REDDY. Absorption of
bacterial infections. Gut 12: 1001, 1971. labelled vitamin A in children during infection.
9. EINSTEIN, L. P., D. M. MACKAY AND I. H. Ro- Brit. J. Nutr. 27: 299, 1972.
SENBERG. Pediatric xylose malabsorption in East 26. BACK, E. H., R. D. MONTGOMERY AND E. E.
Pakistan: correlation with age, growth retardation, WARD. Neurological manifestations of magnesium
and weanling diarrhea. Am. J. Clin. Nutr. 25: deficiency in infantile gastro-enteritis and malnu-
1230, 1972. trition. Arch. Diseases Childhood 37: 106, 1962.
10. TORRES-PINEDO, R., C. RIVERA AND H. RODRI- 27. TURK, D. E., AND J. F. STEPHENS. Upper intes-
GUEZ. Intestinal absorptive defects associated with tinal tract infection produced by E. acervulina and
enteric infections in infants. Ann. N. Y. Acad. Sci. absorption of 6’Zn and ‘3tI-labeled oleic acid. J.
176: 284, 1971. Nutr. 93: 161, 1967.
11. LUGO-DE-RIVERA, C., H. RODRIGUEZ AND R. 28. SOLOMON, N. W., F. VITERI AND L. HAMILTON.
MALABSORPTION, DIARRHEA, AND INTESTINAL INFECTIONS 1253