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MOCK TEST 3
1-What is pH of 0.1M NaOH A-1 B-6 C-0.1 D-13 E-14 Ans-D pH + pOH = 14 to find the pH. pOH = - log[OH] = - log 0.1 = +1 pH = 14 - pOH = 14 - 1 = 13

2-LN is 60 years old. Yet he is a healthy adult without any major medical conditions other than osteoarthritis. He is having a BP of 160/82 for the last two months. Which of the followings is the best choice for him? He takes Tylenol for Osteoarthritis. A. Amlodipine B. Ramipril C. Atenolol D. Losartan E. Carvedilol Ans-A Read: Monitoring blood pressure, and drug choices for bp.

3- Which attempts to define clinical parameters and cost effectiveness of two drugs can be compared by? A-Cost effective analysis (CEA) B-Cost utility analysis (CUA) C-Cost minimization analysis (CMA) D-Cost Benefit analysis (CBA) E-All of the above Ans-A Tips: Pharmacoeconomics is for society QUALY SF-36

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4-Sulphur ointment may be used in acne treatment, it may contain mineral oil. It is added as? A-Levigating agent B-Lubricating agent C-Emulsifying agent D-Wetting agent E-Solvent Ans-a

5-Herceptin (Trastuzumab), is A-Treatment of HER2-overexpressing metastatic breast cancer B-Tumor necrosis factor alpha inhibitor C-Glycoprotein inhibitor D-Interluekin E-Inteferons Ans-A Read: Definition of Pharmacogenetics drugs

6-Hydroxylapatite can be found in? A- Teeth and bones within the human body B- Freely flowing in blood circulation C- Increase blood coagulation D- It is found in brain cells E- It is present in cardiac tissues Ans-A

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www.pharmacyprep.com 7-Increased heart rate is the side effect of? A-Anti cholinergic B-Sympathomimetics C-Sympathetic blockers D-Non dihydropyridine type of CCBs E-All of the above Ans-B

8-In rare cases anticholesterol drugs statins side effect may cause muscle cells to break down. This rare but potentially life-threatening side effect is known as rhabdomyolysis. The most common signs and symptoms of rhabdomyolysis include all except? A-Severe muscle aching throughout the body B-Muscle pains C-Muscle weakness D-Dark or cola color urine E-Fruity smell from breathing Ans-E Tips: In rhabdomyolysis increases CK-MM

9-A 55 year old diabetec patient using oral antidiabetic drugs. His current medication include, metformin 1000 mg, and glicalizide 40 mg daily. His lifestyle include, exercise 3 to 4 time per week, and diet consius, however, occasionally drinks alcohol and smokes in parties. Which of the following drugs are not associated with hypoglycemic symptoms? A-Glyburide B-Gliclizide C-Glicalizide + metformin D-Metformin E-Chlorpropamide Ans-D

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www.pharmacyprep.com 10-All of the following are the more common causes and factors which may contribute to hypoglycemia, except? A-Missed meals B-Excessive alcohol C-Corticosteroids D-Exaustive excercises E-Insulin-secreting pancreatic tumor Ans-C

11-Liver cirrhosis is a type of end stage chronic liver disease? What clinical laboratory tests are elevated? A-ALT B-AST C-Bilrubin D-Albumin E-Proteins Ans-C

12-Allergic rhinitis is a common condition, affecting about 1 in 5 Canadians. Symptoms can be mild or severe. All of the following are the symptoms of allergic rhinitis, except? A-Itchy mouth, throat, ears, and face B-Sore throat C-Dry cough D-Hives E-Sneezing Ans-D

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www.pharmacyprep.com 13-What antidepressant likely give high weight gain side effect? A-Fluoxetine B-Buprapion C-Mirtazepine D-Amitriptyline E-Moclebamide Ans-C

14-Moclebamide is? A-SNRI B-SSRI C-Irreversible MAO I D-Reversible MAO I E-MAO type B inhibitors Ans-D

15- The only antibiotic available as chew able tablet include: a) Penicillin b) Amoxacillin c) Ampicillin d) Erytromycin e) Claritromycin Ans-B

16- Symptoms of heart failure include? A-Cough B-Dyspnea C-Fatigue D-Bradycardia E-Pulmonary edema Ans-B

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17-What is incorrect statement about metformin? A-Should taken with or after meals B-Decrease gluconeogenesis C-Increase glucose uptake D-Avoid in sulpha allergy E-May cause anorexia Ans-D

18-For a weak acid, when the pH of the solution is the same as that of the pKa of the acid, the percentage of ionization of the acid will be: A 25% B 50% C 75% D 100% E 99% Ans-B

19-All of the following are prodrugs, except? A-Captopril B-Enalapril C-Moexipril D-Fosinopril E-Ramipril Ans-A Tips: captopril and lisinopril are active drugs and listed 7 other ACE inhibitors approved in the United States that are inactive prodrug until metabolized in the liver.

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www.pharmacyprep.com 20-All of the following are symptoms of seasonal flu, except? A-Fever B-Sore throat C-Dry cough D-Hives E-Body aches Ans-D

21-Which of the following iron salts has the greatest amount of elementary iron? a. Ferrous gluconate b. Dried ferrous sulfate c. Ferrous fumarate d. Ferrous sulfate Ans: c Ferrous fumarate 33% Ferrous sulfate 20% Dried ferrous sulfate 30% Ferrous gluconate 12% Iron supplements absorption is increased by ascorbic acid \

22-A 30-year-old man diagnosed with esophageal ulcer, all of the following factor may increase risk of ulcer, except? A-smoking B- spicy and fatty foods C- reclining after meals D-NSAIDs E-Proton pump inhibitors Ans-E

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www.pharmacyprep.com 23-What hormone may increase in pregnancy? A-estrogen B-Gonadotropin hormone (GTH) C-Follicular stimulating hormone D-Leutinizing hormone E-Prolactin Ans-B

24-Which of the following ophthalmic preparations have higher bioavailability? A-ophthalmic solutions B-ophthalmic suspensions C-Ophthalmic liquid D-Ophthalmic drops E-all of the above Ans-B Tips:Ophthalmic liquids, and drops, often slip from, thus have less have bioavailability Ophthalmic preservative are benzalkonium chloride + EDTA 0.001% Polyvinyl alcohol in used in ophthalmic preps to enhance viscosity.

25. Oleaginous base include: a) Cold cream b) Lanoline c) Petrolatum d) A and B e) B and C Ans: E Read: water soluble bases in used in suppositories like Polyethelene glycol. Suppository base temperature should be around 35 oC.

26- A clinical trial for a drug A on 300 patients shows no difference. Again trail done on 30,000 patients shows difference. What is appropriate biostatical hypothesis error? A-Type I error B- Increase in sample size C- Type II error D-Probability of error E-None of the above Ans-C

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www.pharmacyprep.com Read: p= probability of error, it is level of significance in type I error (false +ve).

27-Which of the following increase flow of tablet? A-Lubricant B-Glidant C-Humectants D-Water E-Surfactant Ans-B

28-Which of the following may increase potassium levels (K+)? I-Renal failure II-ACE I III-Adrenal gland dysfunction A-I only B-III only C- I and II only D-II and III only E-I, II, and III Ans-E Read: Factors and drugs that increase potassium ion

29- The formation of an insoluble precipitate as a result of admixing calcium and phosphate is an example of what type of incompatibility. a) Chemical b) Physical c) Pharmacological d) Medical e) Therapeutic Ans: B

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www.pharmacyprep.com 30. Parenteral group products in ampoules undergo what type of testing to ensure the integrity of this parenteral container. a) Clarity b) Leaking testing c) Pyrogen testing d) Sterility testing e) Solubility testing Ans-B Read: most common contaminant sterile preps and the type of laminar flow hood used for cytotoxic. Methods of sterilizations.

31-Vitamin overdose that can be toxic? A-Vitamin A B-Vitamin B C-Vitamin C D-Vitamin D E-Vitamin E Ans-A

32. Technician do all EXCEPT: a) Mix admixture b) Prepare Rx c) Take order d) Counsel for new Rx e) Literature search from internet Ans: D

33-A mother comes into your pharmacy requesting something to prevent a childs, allergic reactions, on her vacation visit on mountains. All of the following are correct about epipen EXCEPT; A-Prevents life threatening asthma B-Prevents food allergies C-Prevents cardiac arrhythmias D-Can be prevented severe hives E-Prevents angioedema Ans-C

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34- A 60 year obese patient with cellulites skin infections, which of the following organisms that cause cellulites? A-S. aureus B-S. epidermiditis C-S. Pneumonia D-S. Pyogenes E-P. aeruginosa Ans-A and D

35: What is correct of preparing prescription of coaltar:calamine 1gr of aa: A-take 1 gram of calamine apply affected area B-take 1 gram of coaltar and 1 gram of calamine C-Apply affected area combination of coaltar and calamine D-Apply coaltar 1 gram E-None of the above Ans: B

36-After depolarization the cell will recover by? I-Close Na+ channel II-Close Ca2+ channel III-Open K+ channel A-I only B-III only C- I and II only D-II and III only E-I, II, and III Ans-E Read: action potential curve.

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www.pharmacyprep.com 37. Which of the following phase(s) is/are generally dominated by estrogen? A. Follicular phase B. Ovulatory phase C. Luteal phase D. LH Surge E. All of the above Ans-A

38. Which of the following about Metabolic Acidosis is NOT TRUE? a. It generally occurs due to loss of bicarbonate from the body. b. Hypokalemia is generally a result of metabolic acidosis. c. Administration of arginine HCl generally resolves metabolic acidosis d. It stimulates the respiratory center to increase excretion of CO2 from the body. Ans: C Read: Metabolic acidosis: Increase CO2

39-Which of the following acids has the highest degree of ionization in aqueous solutions: A-Warfarin pKa = 6.0 B-Naproxen pKa = 5.0 C-Aspirin pKa = 3.0 D-Phenobarbital = pKa = 7.5 Ans-C Tips: pKa is the indicator of relative strength of an acid drug. The lower the pKa the stronger the acid. The stronger the acid the greater ionization in aqueous solution.

40. Which of the following is NOT a sign of Graves disease? a. Fast heartbeat b. Weight gain c. Soft skin d. High basal metabolic rate Ans: b Tips: Excessive secretion of the thyroid hormone causes Graves disease. Staring eyes, weight loss, soft skin, fast heartbeat, high BMR and a sharp and anxious mind are the symptoms of the Graves disease. Read: Laboratory tests for hypo and hyperthyroidism

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www.pharmacyprep.com 41-A patient is using dextromethorphan for cough, which of the following drug may concern pharmacist? A-Alcohol B-Diphenhydramine C-Dimenhydrinate D-Phenelzine E-Citalopram Ans-D Read: MAO Inhibitor drug interactions

42-What are the common signs and symptoms of vaginal candiasis include? I-Vulvular pruritus and burning II-Thick, white vaginal discharge III-Foul smelling (fishy odor) discharge A-I only B-III only C- I and II only D-II and III only E-I, II, and III Ans-C

43. The increase in mutual solubility of two partially miscible liquids by the addition of a third substance is defined as: a. Catalyst b. Blending c. Promoter d. Levigation Ans: b * Catalyst: A substance that increases the rate of reaction without being involved in the reaction. * Promoter: The substance that increases the activity of catalysts, i.e., A CU2+ ion promotes the catalytic action of an Fe+3 ion in the decomposition of H2O2.

44. Which of the following factors does not affect the protein binding of a drug? a. The availability of protein for binding b. Binding affinity of protein to the drug c. The presence of competing substances for protein binding d. The concentration of a drug at its receptor site Ans: d

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www.pharmacyprep.com The factors that affect the protein binding of drugs are: * Type of proteins available for binding * The protein binding affinity and capacity of drug * The presence of competing substances for protein binding * The disease condition that may alter the amount of protein available for binding 45-All of the following drugs can be used to treat the vulvovaginal candiasis, Except? A-Clotrimazole B-Nystatin C-Fluconazole D-Metronidazole E-Butoconazole Ans-D

46-Which of the following HMG Co reductase inhibitor has lactones ring? A-Atorvastatin B-Lovastatins C-Pravastatin D- Sinvastatin E-All statins Ans-B Read: Structure activity of statins.

47-What cytochrome enzyme catalyzes the oxidation of dihydropyridine calcium channel blockers?
NO2 H3COOC H3C N H COOCH3 H3COOC CH3 H3C N

NO2 COOCH3 CH3

A-UDP GT B-CYP 2C9 C-CYP 2D6 D-CYP 3A4 E-Cytochrome oxidase Ans-D

48. A PRIMARY symptom of an incontinent patient is a) Intermittent claudication Copyright Tips Inc Protect copyrights and prevent piracy 14

www.pharmacyprep.com b) An impacted bowel c) Frequent urination d) Partial impotency e) Severe mental depression Answer: C

49-What is considered as complementary services? A- If a person uses it in addition to taking conventional medicine or therapies. B- if a person uses health care approach exclusively C- If a person uses conventional medicine or therapies alone D- If person used herbal or natural product therapy E- None of the above Ans-A

50-What is correct about alternative services? A. If a person uses it in addition to taking conventional medicine or therapies. B. If a person uses health care approach exclusively C. If a person uses conventional medicine or therapies alone D. If person used herbal or natural product therapy E. None of the above Ans-B

51. Anti-inflammatory agents, such as ASA, interfere with hemostasis by a) activating antithrombin b) preventing vasoconstriction c) inhibiting thrombin generation d) Inhibiting platelet aggregation e) Inhibiting polymerization Answer: D Read: Mechanism of ASA actions such as anti-inflammatory, analgesic, antiplatelet, and antipyretics. Acetaminophen mechanism, metabolism, and toxicity

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52. Which of the following prostaglandins have a gastric mucosal protection property? a. PGE1 b-PGF2C- PGI2, D-PGE2, E-PGD2 Ans: A Read: prostaglandin analogs classifications

53. Which of the following receptor(s) is/are associated with emesis? I H1 receptors II D2 receptors III 5HT3 receptors a. I only b. III only c. I and II only d. II and III only e. I, II, and III Ans: e Histamine (H1), Dopamine (D2) and Serotonin (5HT3) receptors are associated with nausea and vomiting.

54. Working capital is generally expressed by: a. Inventory ratio to working capital b. The difference between current asset and current liabilities of the pharmacy c. Quick assets ratio to current liability d. Cost of goods ratio to inventory Ans: b

55-You notice Ms As, a young girl of normal weight, in the pharmacy purchasing laxatives. You take the time to talk to her about her laxative use, and find that she has been binge eating and using laxatives about three times per week for the last six months. Based on this information, which of the following statements is most likely to be correct? A. She may have bulimia nervosa of the non-purging type since she is not self-inducing vomiting B. She may have bulimia nervosa of purging type since she uses laxatives C. She does not have bulimia nervosa, since she is of normal weight D. She does not have bulimia nervosa, since her bingeing episodes are not frequent enough Ans: B 56. Which of the following is NOT a physical property of gel? a. Swelling

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www.pharmacyprep.com b. Conductance c. Syneresis d. Aging Ans: b The other choices such as swelling, syneresis (gels will often contract spontaneously and remove some of the fluid medium which is known as syneresis) and aging are physical properties of the gels.

57-Which of the following anticholesterol medication may increase his blood sugar levels: A-Atorvastatin B-Niacin C-Simvastatin D-Fluvastatin E-Gemfibrosil Ans-B

58- Sustain release formulations, advantages include? I-Avoid patient compliance problems II-Reduce fluctuations in drug levels III-Long duration of actions A-I only B-III only C- I and II only D-II and III only E-I, II, and III Ans-E Read: Sustain release formulations

59-Which of the following is NOT a gram-negative bacilli? A- Haemophilus influenza B- E. coli C- Salmonella typhi D- Shigella E- S. aureus Ans-E 60-What antibiotic is drug of choice for meningitis in children? A-Ampicillin

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www.pharmacyprep.com B-Rifampin C-Tetracyclin D-Gentamicin E-Erythromycin Ans-A Read: Meningitis treatment and tuberculosis

61-What viral infections causes drop in CD4 cells over years. A- Human Immunodeficiency Virus B- Hepatitis virus C- Herpes virus D- Warts E- Human papilloma virus Ans-A Read: about warts (HPV) infections

62-Human Immunodeficiency Virus infections are determined by: IPositive ELISA test is 99% is sensitive IIConfirmed by Western Blot Test IIIConfirmed by gel electrophoresis a) I only b) III only c) I and II only d) II and III only e) All of the above Ans-C Read: Elisa tests, western blot tests and gel electrophoresis and HPLC, and MS

63-Acyclovir covers? A-HSV-1 B-HSV-2 C-Vericella zoaster virus D-All of the above E-only A and B only Ans-D

64-Oseltamivir (Tamiflu) is neuro aminidase inhibitor indicated for;

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www.pharmacyprep.com A-Influenza A only B-Influenza B only C-Influenza A+B D-Herpes virus E-All of the above Ans-C

65-Odds ratio (OR) used for? A- Case-control-retrospective studies B- Cohort studies C- Prospective analysis D- Meta analysis E- Risk reduction Ans-A Tips: Odds ratio (OR) used for case-control-retrospective studies. It compares disease unexposed and non-diseased in unexposed population to determine any difference between the two

66-Chi-squared test is used to A-Compare percentages or proportions B- Used to compare two means C- Analysis of variance to compare three or more D-All of the above E-None of the above Ans-A

67-Health Belief Model, indicates a patient would be less likely compliant with therapy if: A-He/she thinks that prescribes drug is appropriate for symptoms B-Thinks that disease is serious C-Thinks that side effect are more than benefit D-Thinks that drug is very active. Ans-C

68-Which of the following categories indicates the use of a drug is restricted during pregnancy?

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www.pharmacyprep.com a. Categorie A b. Categorie B c. Categorie X d. Categorie C e. Categorie D Ans-C Below are the categories and their effect on pregnancies: A = Controlled studies show no risk B = No evidence of risk in humans C = Risk cannot be ruled out D = Positive evidence of risk X = Contraindicated in pregnancy

69. Which of the following is a nonparametric statistic? a. Mean b. T-test c. Chi-square-test d. Standard deviation Ans: C

70-Soft gelatin capsules may have liquid preparations, these are used for which of the following as a marketed product? a. Potassium chloride b. Vitamins c. Nitroglycerin d. Antacids Ans: b Read: Soft and hard capsule shells, and plasticizers in capsules shells.

71-Additives which promote the breaking up of tablets into smaller particles are referred to as: a. Fillers b. Disintegrates c. Lubricants d. Dispersants Ans: b Read: examples of fillers and lubricants 72-Tablet exipient which enhance the flow of granules into the tablet die are: a. Lubricants

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www.pharmacyprep.com b. c. d. A Disintegrant Adhesives Surfactants

Ans:

73-All of the following are signs of stroke, except? A-Bacturia B-Difficulty speaking C-Dysphagea D-Hemeplegia E-Visual disturbances Ans-A Read: Stroke, heart failure and Reynauds phenomenon symptoms

74-A pharmacist uses 50 mls of a 5% solution to make 1250 mls of solution, what is final concentration of solution? A-1:500 B-1:5000 C-1:200 D-10:1000 E-5% Ans-A

75-A doctor prescribes Azithromycin for 4-year-old child. The dose reads 300 mg on day 1, then 150 mg on days 2 to 5. Which one of the following prescription would be dispensed? A. 900 mg bottle of 37.5 mls containing 200 mg/5mL B. 900 mg bottle of 22.5 mls containing 200 mg/5mL C. 300 mg bottle of 9 mls containing 100 mg/5ml D. 600 mg bottle of 15 mls containing 200 mg/mL E. 300 mg bottle of 15 mls containing 100 mg/5ml Ans-B

76-All can cause withdrawal effect EXCEPT:

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www.pharmacyprep.com A. Lorazepam B. Alcohol C. Dextromethorphan D. Buspirone E. Morphine Ans-D Read: Nicotine withdrawal symptoms

77- A lady in her menopause may experience the following symptoms, except: A-Tachycardia B-Hot flushes C-Osteoporosis D-Increase incidence of fracture E-Urethral infection Ans. E Tips: vaginal dryness, hot flushes and osteoporosis are common symptoms of menopause.

78. All of the following are true for phenytoin, EXCEPT: a) May be used for generalized tonic seizures b) May be used for absence seizures c) May be used for partial seizures d) May be used for trigeminal myalgias e) Is a hydantoin derivative Ans: B Read: gabapentine

79. An MAOI may be administered concomitantly with

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www.pharmacyprep.com I. II. III. Another MAOI A sympathomimetics A benzodiazepines

a) I only b) III only c) I and II only d) II and III only e) All of the above Ans-B

80- A patient taking a TCA, an antihistamine and an antipsychotic may develop I. II. III. Dry mouth CNS toxicity Tachycardia

a) I only b) III only c) I and II only d) II and III only e) All of the above Ans-E

81-All are alkylating agents, except? A. Cyclophosphamide B. Chlorambucil C. Melphalan D. Busulphan E. Methotrexate F. Carmustin Ans-E Read: anticancer drugs classification and chemotherapy SE, especially N&V.

82-Which of the following agents may be administered to prevent hemorrhagic cystitis? A. Dexamethasone

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www.pharmacyprep.com B. C. D. E. Allopurinol Mesna Dolasetron Methylene blue

Answer: C Mesna is a selective urinary tract protectant. It binds directly to the toxic metabolite, acrolein, and blocks damage to the bladder.

83-The most common business structure is incorporation, what is the advantage of incorporation? I-Several directors are possible II-Large number of stock share holders III-No direct relationship of stockholders in debts and liabilities in case of bankruptcy Ans-E

84. All of the following drugs is contraindicated in pregnant women, except? a. Methotrexate b. Isotretinoin c. Warfarin d. Heparin E-Lipitor Ans: D

85: Which of the following medication has not been shown to cause an exacerbation of asthma? A. ASA B. Propranolol C. Ibuprofen D. Lisinopril Ans-D Tips: Avoid ASA, NSAIDs, and COX2-inh. Read: COX-2 inhibitor, indications 86-You have on hand 10ml ampule of 1/2000 solution. How much of the solution would be needed to give 500ml of 0.35mg/100ml of the solution? A-7 ml

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www.pharmacyprep.com B-3.5 ml C-14 ml D-20 ml E-2.0 ml Ans-B Working 0.35mg = 100ml X 500ml X= 1.75mg 1000mg = 1.75mg 2000ml X

X= (1.75) (2000) 1000 = 3.5ml 87. In elderly the needs of multivitamins, which is true: A. Vitamin E deficiency is common in elderly B. Vitamin D deficiency is common in elderly C. Iron deficiency is common in elderly D. Vitamin B12 is needed E. Vitamin A is essential to prevent vision loss Ans-D Read: In seniors, physiological changes.

88-A man enters at end of March requesting photocopy of his receipt and family for income tax purpose. Upon investigation you found that two teenager age 13 and 14 year old and wife are also on his list. What is decision of pharmacist? A Makes photocopy of receipt and give free B Give him for some money C Get permission from wife D Get permission from all members of family Ans-D

89-The most expensive in pharmacy business? A-pharmaceuticals B-Hospitals

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www.pharmacyprep.com C-Payrolls D-Over the counter drugs E-Inventory Ans-C

90-The most expensive healthcare system in Canada? A-Pharmacist salaries B-Doctor salaries C-Hospitalization D-Nurses salaries E-Dentist salaries Ans-C

91-The second most expensive in healthcare system in Canada? A-Pharmacist salaries B-Doctor salaries C-Hospitalization D-Nurses salaries E-Dentist salaries Ans-B 92-The Canadian healthcare system is the universal healthcare, thus expenditure is dependent on? A-City taxes B-GST and PST C-Federal and Provincial taxes + voluntary services D-Patient pay per visit E-pharmaceutical industry Ans-C

93- All of the following may be recommended OTC for the treatment of Tinea pedis, EXCEPT: a) Nystatin b) Tolnaftate

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www.pharmacyprep.com c) Clotrimazole d) Miconazole Ans: A

94-Net profit is? A: Gross margin-expenses B: gross profit+expenses C:assets-liabilities D-None Ans-A

95. The pneumococcal vaccine DOES NOT reduce the risk of a) Pharyngitis b) Endocarditis c) Otitis media d) Meningitis e) Bacteremia Ans: B

96. Zofran (Ondansteron) is: I. 5HT3 antagonist II. Used as anti-emetic in cancer ill patients III. In case of overdose we cant use emetic Ipecac as zofran is anti-emetic a) I only b) III only c) I and II only d) II and III only e) All of the above Ans: E

97-What part (s) of the syringe should not be touched? I Needle

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www.pharmacyprep.com II III A. I only B. III only C. I and II D. II and III E. I, II and III Ans-A Plunger Barrel

98-Vitamin A deficiency may cause? A-Keratitis B-Blindness C-Osteomalacia D-Osteoporosis E-Acne Ans-B

99-All of the following are appropriate counseling advice/information for Alendronate EXCEPT A. Takes 70 mg/wk once weekly in the morning B. Take 30 minutes before meals or other medications C. Take 10 mg/d daily once in the morning D. Remain upright for 30 min after dose E. Can take every alternate day Ans-E

100-The neuroleptic drug most associated with dose related pigmented retinopathy is A. Haloperidol B. Trifluoroperazine

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www.pharmacyprep.com C. Thioridazine (Mellaril) D. Methotrimeprazine E. Loxapine Ans-C Tips; The retinal pigmentation has been associated with a dose in excess of the maximum recommended dose of 800 mg over a long period of time.

101-Which drug do NOT requires replacement in pituitary failure? A-Calcitonin B- Cortisol C- Thyroxin D-Oxytocin E-Vasopressin Ans-A Tips- (Calcitonin is secreted by thyroid gland) (Hormones produced by pituitary gland are Posterior lobe (Oxitocin, Vasopressin) Anterior lobe (Corticotropin ACTH (Cortisone, Hydrocortisone) Thyrotropin TSH, Thyrotropin releasing hormone TRH, Growth hormone GH.) Read: anterior and posterior pituitary secretions.

102-Toxicity of methyl alcohol is caused by formic acid, which treated with A-Ethanol (Ethyl alcohol) B-Formaldehyde C-Benzyl Alcohol D-Naltrexone E-Atropine Ans-A

103-Expiry dates of pharmaceutical dosage form can be determined by A-Accelerated stability studies B-Antioxidants C-Heat degradation D-Photolysis E-None of the above Ans-A

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www.pharmacyprep.com 104-What is banner pharmacy? A-It is type of ownership pharmacy, in which pharmacist is a partner B-It is a franchise awarded exclusively to pharmacist who must retain ownership. In return they pay certain fee to the company. C-It is type of ownership in which pharmacy independently incorporated. D-It is type of leasing E-None of the above Ans-B Tips: joe and jill, partners, one of them have sold illegal drugs.

105-What is drug of choice in treatment of a patient suffering from gonorrhea (Gonococcal infection)? A-Ceftriaxone B-Pencillin G C-Vancomycin D-Gentamycin E-Tetracyclin Ans-A Tips: (The treatment of gonococcal infection is) Doc is Cephalosporins Ceftriaxone 125 mg IM single dose Cefixime (Suprax) 400 mg po single dose

106-Treatment of a pregnant woman with urinary tract infection a. Cephalexin b. Ciprofloxacin c. Tetracyclin d. Metronidazole e. Nitrofurantoin Ans-A Tips: A drug used in treatment of urinary tract infection Ciprofloxcin

107-Oral decongestants (Pseudoephedrine and Trinalin) should be avoid with A. Hypertension B. Prostatic hypertrophy

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www.pharmacyprep.com C. Narrow angel glaucoma D. With MAO inhibitors E. All of above Ans-E

108-An enzyme that cleaves deoxyribonucleic acid (DNA) at a specific site is called: A-Ligase B-Restrictive ribonuclease C-Restrictive endonuclease D-Lyase E-None of the above Ans-C Read: all molecular biology

109-Which of the following is not associated with plasmids? A-Phage B-eukaryotes C-Prokaryotes D-virus E-E. coli Ans-B

110-A new antidepressant is administrated, when ingested together with fruit juice we can see a decrease in the quantity of drug eliminated unchanged in the urine. When administrated together with antacids the drug increase the elimination rate. We can conclude that this drug is: a) Weak base b) Weak acid c) Hydrophobic drug d) Strong base e) Neutral drug Ans-B

111-Docosanol (abreva) is a over the counter product, is indicated for? A-ivy poisoning B-Aphthous ulcers

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www.pharmacyprep.com C-Stomatitis D-Cold sore E-Canker sore Ans-D

112-Stability of room temperature for trans dermal patch follows A-zero order B-1st order C-2nd order D-3rd order E-None of the above Ans-A

113-A pharmacist failure to meet the standards of practice and avoiding discussion to patient about the effect of drugs is defined as? A-Justice B-Fidelity C-Negligence D-Compassionate E-Veracity Ans-C

114- A nurse brings a prescription to the hospital pharmacy asking the pharmacist how to prepare the following prescription for a 155lb patient: Rx: Dopamine 200mg in 500ml solution Inject 5ug/kg/min The nurse needs to know the rate/ml in which she should infuse the medication. Which of the following concentration of the drug/ml should be infused? a) 100g/ml b) 200g/ml c) 300g/ml d) 400g/ml e) 500g/ml Ans- D Working Final concentration 200mg-----500ml mg to ug, 200 x 1000 = 200 000ug in 500ml 200 000ug ------500ml ? ---------- 1ml = 400ug/ml

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www.pharmacyprep.com 115- We receive the following prescription: Rx. Tetracaine 1.0% Boric acid 0.5% Water qs 100% Dispense 60mls ophthalmic solution. How many mg of NaCl is needed to adjust the isotonicity of this solution? (E values are 0.18 for tetracaine and 0.5 for boric acid) a) 108mg b) 77mg c) 128mg d) 718mg e) 282 mg Ans- E Calculate the wt of tetracaine 60mls x 0.1 (because is 1%) = 600mg Wt of tetracaine is equivalent to 600mg x 0.18 = 108mg of NaCl.

116-If 10 L of a 10% solution are diluted to 25 L, what is the percentage strength of the dilution? A-10% B-4% C-25% D-8% E-100% Ans-B

10L
=

x% 10%

4%

25L

117- Calculate the turn over of a pharmacy with the following sales information: -Inventory of the beginning of the year: $3.000,00 -Inventory of the end of the year: $27.000,00 -Average inventory: $15.000,00 -Total of sales: $75.000,00 a) 2 b) 3 c) 4 d) 5 e) 6 Ans-D Read: Turnover rate

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118-A customer is experiencing hemorrhoids and comes to pharmacy for your advice, what is appropriate? A-Avoid straining during defecation B-Increase fiber diet C-Increase fluid intake D-All of the above E-Decrease fiber diet And-D

119- A young person needs sleep aid; before you give any OTC sleep aid to him, advise him: a) Try to do exercises daily b) Try to read a book before go bed c) Try regular sleep d) Try to adjust a regular sleep schedule e) All are correct Ans-E

120- Important analysis that should be done prior to choose an area to build a pharmacy: a) Demographic analysis b) Concurrence analysis of hardware and food store c) Traffic analysis d) Market area analysis e) School location analysis Ans-D 121. A psycho patient tend to spit out tablets after nurse gives them to him. Which is appropriate, dosage form? : a) Oral tablets b) Capsules c) Sustain release tablets d) Rapid dissolve e) Liquid Ans-D

122. Difference between Heparin and low molecular weight heparins (LMWH), except a) LMWH have longer t than heparin b) LMWH have only subcutaneous injections

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www.pharmacyprep.com c) Heparins have iv injections and subcutaneous injections d) LMWH is monitored by aPTT e) Protamine sulphate is antidote of heparins Ans-D

123- Absolute risk, reduction is? A-(placebo events) (treatment events) B-1/absolute risk reduction C-[EER-CER]/EER D- ARR placebo events E-None of the above Ans-A Read: absolute and relative risk reduction

124- Gingo Biloba prescribed in A-Alzheimer disease B-Parkinsons disease C-Delirium D-Nausea and vomiting E-Insomnia Ans-A

125-What is palliative care? a) Care of the patient in the terminal (last) stages of life b) Support offered to family members of patients c) Cancer chemotherapy of patient d) Schizophrenic patient care e) Diabetic care Ans-A

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126-Menieres Disease symptoms include: I-Deafness II-Tinnitus III-Dizziness. A-I only B-III only C-I and II only D-II and III only E-All of the above Ans-E

127-All of the following are the risk factors of developing atherosclerosis, except A-Family history B-Male C-high blood pressure D-high LDL E-high HDL Ans-E

128-Body mass index (BMI) is measured by? A-weight/height x height B-height/weight C-weight x weight/height D-weight/height E-height x height/weight Ans-a

129-a patient is experiencing nausea and vomiting, before chemotherapy is administered, is referred as? A-delayed nausea and vomiting

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www.pharmacyprep.com B-anticipatory nausea and vomiting C-post chemotherapy nausea and vomiting D-chemotherapy depression E-None of the above Ans-B

130-Which of following can be used for chemotherapeutic agents induced nausea and vomiting? A-Ondansetron B-Tamoxefine C-Peclitaxel D-low dose of methotrexate E-Cisplatin Ans-A

131-A 3 months old child have diaper rashes. What is treatment of complicated diaper rash? A-0.5% hydrocortisone B-15% Zinc oxide C-30% Zinc oxide D-Nystatin E-Moisturiser cream Ans-D

132-A customer is experiencing hemorrhoids and comes to pharmacy for your advice, what is appropriate? A-Avoid straining during defecation

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www.pharmacyprep.com B-Increase fiber diet C-Increase fluid intake D-all of the above E-None of the above And-D

133-A pharmacist failure to meet the standards of practice and avoiding discussion to patient about the effect of drugs is defined as? A-Justice B-Fidelity C-Negligence D-Compassionate E-Veracity Ans-C

134-If the rate of elimination of a drug is reduced because of impaired renal function (proved by ClCr test), the half-life and the time required to reach steady state plasma level will be? A-Increased B-Decreased C-No change D-Not predictable E-It is first order elimination Ans-A

135-advantage of soft lenses over hard lenses, except? A- May protect ultra violet light protection B- Usually disposable C-Allow oxygen to reach cornea D-Long durable than hard lenses E-Less chances of infection Ans-D Read: soft and hard lense

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136. In gravimetric analysis, pH is adjusted to: A. Avoid the precipitation of impurities B. Facilitate maximum precipitation C. Achieve easily filterable precipitate D. Prevent coprecipitation E. Form insoluble hydroxides or hydrous oxides to precipitate. Ans-E

137-Raynauds disease: I-pallor II-cyanosis of the finger or toes III-Arterial plaques A-I only B-III only C-I and II only D-II and III only E-All of the above Ans-C

138. Surface active agent for contact lens: I. Prevents microbial growth II. Slow drug releases III. Improves wet ability A.I only B. III only C.I and II only D. II and III only E. All of the Above Ans-D

139-Phenothiaziens must have nitrogen containing side chain substituent on the ring nitrogen for anti psychotic activity. This ring and side chain nitrogen must be separated by a a) One carbon chain

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www.pharmacyprep.com b) Two carbon chain c) Three carbon chain d) Four carbon chain e) Five carbon chain Ans: C

140- Multiple sclerosis treatment includes all, except? A-Prednisone B-Interferon beta 1b C- Natalizumab D- Glatiramer acetate E-Donepezil Ans-E

141- Colorectal cancer detection methods or screening or monitoring I-Colonoscopy II-Annual guaiac fecal occult blood testing (FOBT) III-Differential blood test A-I only B-III only C-I and II only D-II and III only E-All of the above Ans-C

142-What is a technique to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence A. Gene target

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www.pharmacyprep.com B. C. D. E. Ans-D Gene technology Genetic cloning Polymerase chain reaction (PCR) DNA fingerprinting

143-Genome is? A-complete sequence of DNA in a organism B-complete set of gene in organism C-Complete set of codons in organism D-Study of genes E-Genetic cloning Ans-a

144-The federal government oversees drug benefit programs for the following client groups: except A-First nations (aboriginals) B-Veterans C-Refugees D-Inmates of federal penitentiaries E-Seniors over 65-year age Ans-E

145- Papilloma virus causes a popularly infection called: a) Common wart b) Anatomical wart c) Seborrheic wart d) Venereal wart e) Plane wart Ans-A

146- A researcher develops a new drug to prevent the common cold in children over the of two. 1000 children received placebo and 1000 received the drug. During the one year follow up

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www.pharmacyprep.com the research diagnosed colds in 2.5% of the kids on placebo and in 2% of the active treatment. What is the absolute risk reduction? A-0.5% B-20% C-10% D-40% E-5% Ans-A Tips: 2.5 2.0 = 0.5%

147- complementary DNA (cDNA) is DNA synthesized from a: A-mature mRNA template in a reaction catalyzed by the enzyme reverse transcriptase B-mature tRNA template in a reaction catalyzed by the enzyme reverse transcriptase C- mature rRNA template in a reaction catalyzed by the enzyme reverse transcriptase D- mature DNA template in a reaction catalyzed by the enzyme reverse transcriptase E-None of the above Ans-A

148-Choose correct answer about linolinic acid and linoleic acid: I-Linolinic acid is should be taken with diet II-Linolinic acid and linoleic acid have only difference of double bond in chemical structure III-Both of them are essential fatty acids a) I only b) III only c) I and II only d) II and III only e) All are correct Ans-E

149-What is true about charcoal? IIncrease surface area increase adsorption, IIDecrease impurities on surface of charcoal increase adsorption.

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www.pharmacyprep.com IIIIncrease temperature on surface of charcoal increase adsorption. a) I only b) III only c) I and II only d) II and III only E-All are correct Ans-E

150. Cellulose acetate phthalate is used in a) Enteric coating b) Film coating c) Sugar coating d) Agar coating e) Tablet polishing Ans: A

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