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Course : 6 Year : 2009 Language : English Country : Nepal City : Kathmandu Weight : 557 kb Related text : No
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Compartment Modelling
x Target Level
V1 (Plasma)
EFFECT SITE
Maintenance Infusion
Plasma
Concentration x Clearance
3 Compartment Model
TIVA - Aims
1. BOLUS Dose to reach initial target and induce patient: 2. Maintenance Infusion to keep patient asleep by replacing:
CLEARANCE
Elimination Half Life and Clearance values of a drug are not useful in helping to determine the offset of effect of a drug infusion.
Context Sensitive refers to length of infusion. The drugs we want for TIVA ideally would be context INSENSITIVE.
CSHT - Hypnotics
BAD FOR TIVA
CSHT - Opioids
BAD FOR TIVA
Ketamine/Midazolam
Ket/Midaz
TIVA equivalent to Halothane/N20 anaesthesia in intraoperative stability and postoperative recovery profile
The ONLY way to do it in the USA as TCI models are not approved for use. ONE RECIPE THAT WORKS The Roberts Method
1.
Bolus 1 mg/kg propofol 2. Start infusion at 10 mg/kg/hr for first 10 minutes 3. Decrease to 8 mg/kg/hr for next 10 minutes 4. Infuse at 6 mg/kg/hr until the end of the case
TITRATE TO EFFECT!
A TARGET CONTROLLED infusion is one where the user attempts to achieve a target level of drug in the tissue of interest.
Several models exist: (Marsh, Schnider, Kataria models) Differences between the models include:
Differing values for kinetic and dynamic variables Covariates adjusted for ( age, weight, sex )
All have their advantages and disadvantages. Just pick one model and get to know it well. Marsh model is the most popular.
Entering the patients WEIGHT is the most important variable.
Marsh model gives 180kg patient three times as much propofol as a 60 kg patient Inappropriate. Schnider model uses Lean Body Mass according to height. BUT a 180 kg patient will receive less propofol than a 120 kg patient Inappropriate. So what should I do?
Difficult
PROPOFOL - TCI
6-8 mcg/ml in healthy patients Decrease in the elderly or unwell Alter as appropriate throughout the case
Current Time
PROPOFOL - TCI
The target level ( pharmaco kinetics ) is much less variable between patients than the PHARMACODYNAMIC response to propofol.
Remifentanil
Ultra short acting opioid. Manual Infusion very popular as plasma levels rise very quickly:
0.25 mcg/kg/min initially Titrate within range 0.03 0.5 mcg/kg/min during case Wears off within 10 minutes regardless of length of infusion
Pharmacodynamic response HIGHLY VARIABLE Hypotension and bradycardia can be a problem. Patients almost always need mechanical ventilation.
Remifentanil
Remifentanil TIVA:
Minto
Model Adjusts infusion for age, sex, weight, and gender Leads to less variability in response amongst patient groups Start initially at 3 ng/ml Adjust during case to 1- 12 ng/ml
Propofol/Opioid Synergy
Anaesthesia Analgesia
Very difficult to produce anaesthesia with one drug alone. Propofol COMBINED with opioid has synergistic effects. Combination of the 2 drugs means much less of each drug is needed, leading to fewer side effects. Tailor the ratio of propofol to opioid to the patient
TIVA - Advantages
Decreased Post Operative Nausea and Vomiting Decreased exposure of staff and environment to anaesthetic gases
TIVA - Disadvantages
Expensive:
Infusion Pumps Propofol/Remifentanil
Lack of suitable drugs Wider variety of clinical response at the same drug levels compared with anaesthetic gases
Anaesthesia can be rapidly deepened or lightened. Haemodynamic Stability. No increase in cerebral blood flow
Traditional Teaching Gas Induction Gently increasing TIVA offers a reliable alternative Ensures anaesthesia whilst trying to instrument the airway If obstruction occurs, turning off TIVA leads to faster wake up than inhalational gases. Now widely practised
Do I really need to use a pump? Probably. The Drug Pump is now an extension of your anaesthetic machine. You must check it just as thoroughly before using:
Is your drug dilution correct? Is the syringe and plunger properly held in the clamp? Are your infusion units correct? Is the weight correct (for calculator pumps)? Has the dead space been taken out of the line? Have the batteries been checked? Has the pump been serviced regularly?
Essential
Ensures delivery of drug to the patient and not back up the maintenance fluid.
Even better is a dedicated TIVA set, where the entry point is at the cannula.
Always use the same concentration of drugs and the same syringe sizes.
Advantages:
Patient need less intravenous anaesthesia, with fewer side effects Provides analgesia Cheaper Some anaesthesia is being delivered even if IV cannula fails
Disadvantages:
My Recommendation:
Use N2O with TIVA when you are getting familiar with the technique
You cannot measure the patients plasma drug levels By paralysing the patient you take away one more sign of awareness I always use a BIS monitor If you dont have one, avoid paralysis if possible.
Thiopentone, fentanyl
Combination of hypnotic + opioid means you have to give much less of each. Manual infusions are good, TCI models are better but not a lot better.
Even the best models are only accurate to +/- 20%
Even if you KNOW the plasma level of the drug, you cannot predict the patients RESPONSE. Some patients need more, some patients need less Easy TIVA = TIVA + Nitrous Oxide Much more important than knowing the intricacies of the pharmacokinetics and models is:
Be paranoid about your pump, IV cannula, dead space, one way valve, and syringes. Start at low dose and increase to desired effect USE YOUR CLINICAL JUDGEMENT