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German-Jordanian University

Faculty of Applied Medical Sciences

Department of Biomedical Engineering


Study plan
2008

Program Objectives
Our objective is to prepare graduates who are able to successfully pursue:

Advanced studies leading to research or professional practice in Biomedical Engineering. Advanced studies leading to research or professional practice in the Health and Medical Sciences. An Excellence in undergraduate education, meaningful and innovative research, and service dedicated to advancing the field of Biomedical Engineering. Practice in Biomedical Engineering industries or related technical and professional fields available in Jordan and our partners in Germany.

Learning Outcomes

Analytical and technical skills: Graduates will possess the ability to formulate, analyze and solve problems, both analytically and experimentally, in engineering, biomedical engineering and the life sciences.

Life sciences: Graduates will possess the ability to understand the interconnection between engineering, biomedical engineering, and the life sciences including biology and physiology.

Interdisciplinary approach and career development: Graduates will be able to work effectively in teams to accomplish biomedical engineering and science tasks and understand the importance of each team members ability to contribute in his or her area of expertise. Of particular importance is the interconnection of engineering and clinical personnel towards the solution of problems of compelling clinical and biomedical interest and need.

Creativity: Graduates will be able to evaluate traditional methodologies in the biomedical sciences and the intersection between engineering and medicine in order to devise new approaches to technical and clinical problems.

Research and Development: Research in new materials for implanted artificial organs. Development of new diagnostic instruments for blood analysis. Computer modeling of the function of the human heart. Writing software for the analysis of medical research data. Development of new diagnostic imaging systems. Design of biomedical sensors for measurement of human physiologic system variables. Study of Biomechanics of the human body. Development of new dental materials, and others.

Framework for B.Sc. Degree ( Semester Credits)


Classification Compulsory University Requirements Faculty Requirements Program Requirements: Total = 31 53 75 159 Credit Hours Elective 6 0 12 18 Total 37 53 87 177

1. University Requirements: ( 37 Credit Hours) 1.1-Compulsory : (31 Credit Hours)


Course No.
ARB 301 ENGL 098 ENGL 099 ENGL 101 ENGL 102 ENGL 201 ENGL 202 GER 101 GER 102 GER 201 GER 202 GER 301 GER 302 NE 101 CS 111 MILS 100

Course Title
Advanced Arabic English I English II English III English IV English V English VI German I German II German III German IV German V German VI National Education Computing Fundamentals Military Sciences

Cr. Hr. 3 0 0 1 1 2 2 2 2 2 2 2 2 3 4 3 31

Lecture 3 0 0 1 1 2 2 2 2 2 2 2 2 3 3 3

Lab. 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

Prerequisite ENGL 098 ENGL 099 ENGL 101 ENGL 102 ENGL 201

GER 101 GER 102 GER 201 GER 202 GER 301 GER 302

Total

Student's score on the English Placement Test will decide the course level.

1.2- Electives: (6 Credit Hours)


Course No.
SE 301 IC 101 SFTS 101

Course Title
Social Entrepreneurship & Enterprises Intercultural Communications Soft Skills Total

Cr. Hr. 3 3 3 6

Lecture 3 3 3

Lab. 0 0 0

Prerequisite -

2. Faculty Requirements: (53 Credit Hours)


Course No.
MATH 101 MATH 102 MATH 201 MATH 231 PHYS 101 PHYS 102 ENRE 211 ME 111 BIO 101 CHEM 101 CPE 225 CPE 326 IE 121 IE 353 ME 343 ME 222

Course Title
Calculus I Calculus II Applied Mathematics for Engineers I Probability & Statistics for Engineering Physics I Physics II Electrical Circuits Computer Aided Engineering Drawing Biology General Chemistry Organic Chemistry Biochemistry Workshop Engineering Economics Automatic Control Systems Fluid Mechanics

Cr. hr. 3 3 3 3 4 4 4 3 3 4 4 4 1 3 4 3 53

Lecture 3 3 3 3 3 3 3 1 3 3 3 3 0 3 3 3

Lab. 0 0 0 0 1 1 1 2 0 1 1 1 1 0 1 0

Prerequisite MATH 101 MATH 102 MATH 102

PHYS 101 PHYS 102

CS 111 CHEM 101 BIO 101, CPE 225

MATH 201 MATH 201 MATH 102

Total

3. Program Requirements ( 87 Credit Hours) 3.1-Compulsory: (75 Credit Hours)


Course No.
BME 212 BME 221 BME 321 BME 331 BME 332 BME 391 BME 421 BME 422 BME 499 BME 598 BME 599 CE 211 CE 341 CS 212 CS 361 ENRE 213 ENRE 312 MATH 351 ME 211

Course Title
Anatomy & Physiology Biosignals & Biosystems Medical Signal Processing Biomechanics Biomaterials Field Training Medical Instrumentation I Medical Instrumentation II Practical Training Graduation Project I Graduation Project II Digital Systems Microprocessor and Microcomputer Systems Object-Oriented Programming Database Management Systems Fundamentals of Analog Electronics Fundamentals of Digital Electronics Numerical Analysis Statics & Dynamics

Cr. hr. 4 3 4 4 4 0 4 4 12 3 3 4 4 4 4 4 4 3 3 75

Lecture 3 3 3 3 3 0 3 3 0 0 0 3 3 3 3 3 3 3 3

Lab. 1 0 1 1 1 0 1 1 0 0 0 1 1 1 1 1 1 0 0

Prerequisite
BIO 101 MATH 201, ENRE 211 BME 221 ME 211 CPE 225

ENRE 312, BME 212 BME 421 Dept Approval

BME 598

CS 111 CS 111 CS 111 ENRE 211 ENRE 213 MATH 201 PHYS 101, MATH 102

Total

Students must complete 160 hours of field training in an approved industry in Jordan by the end of their third academic year.

3.2-Electives (12 Credit Hours) 3.2.1- Biomedical System, Biosignals, and Imaging track
Course No.
BME 311 BME 423 BME 424 BME 425 BME 426 BME 427 BME 428 BME 429 BME 521 BME 522 BME 523 BME 524 BME 525 BME 526 BME 527 BME 528 BME 529 BME 552 BME 553 BME 531 BME 532 BME 533 IE 561 TME 554

Course Title
Health Management Systems Magnetic Resonance Imaging Fundamentals of X-ray Modalities Introduction to Ultrasound Technique Medical Image Processing Biosignal Processing Engineering Optics for Medical Applications Photomedicine Reliability and Security of Medical Devices System Safety Fiber Optics Biorobotics Biological Basis of Imaging Quantitative and Functional Imaging Laser/Tissue Interaction Introduction to Ionizing Radiation Fundamentals of Computer Tomography Tenders & Technical Specifications Biomedical Ethics & Safety Human Anthrometric and Physical Measurements Occupational Biomechanics Surgery for Engineers Safety & Ergonomics Logistics Engineering

Cr. Hr.
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3

Lecture
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3

Lab.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0

Prerequisite or Corequisite
CS 361 BME 421 BME 421 BME 421 BME 421 BME 321 BME 421 BME 421 BME 421 BME 421 BME 421 ME 211 BME 421 BME 421 BME 421 BME 421 BME 421

BME 331 BME 331 BME 421 IE 353

4.2.2- Biomechanics, Biomaterial and Tissue Engineering track


Course No.
ME 311 BME 431 BME 432 BME 433 BME 434 BME 435 BME 436 BME 437 BME 438 BME 439 BME 563 BME 564 BME 565 BME 534 BME 535 BME 536 BME 537 BME 538 BME 539 BME 511 IE 561 BME 531 BME 532

Course Title
Strength of Materials Principles of Tissue Engineering Advanced Topics in Tissue Engineering Bone Tissue Regeneration Polymeric Biomaterials Advanced Cardiovascular Biomechanics Biomaterials- Tissue Interactions Tissue Mechanics Composites with biomedical and Materials Biomaterials in the Design of Medical Devices Prosthetics and Orthotics Movement Biomechanics and Rehabilitation Biomechanics of Soft Tissues Biomechanics of Hard Tissues Artificial Organs Drug Delivery Theoretical & Applied Polymer Science Transport Phenomena in Cells and Organs Biotechnology and Bioprocess Engineering Cell Matrix Mechanics Safety & Ergonomics Human Anthrometric and Physical Measurements Occupational Biomechanics

Cr. Hr.
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3

Lecture
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3

Lab.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0

Prerequisite or Corequisite
CS 361 BME 421 BME 421 BME 421 BME 421 BME 321 BME 421 BME 421 BME 421 BME 421 BME 421 ME 211 BME 421 BME 421 BME 421 BME 421 BME 421 BME 331 BME 331 BME 421 -

4.2.3- BioMEMS track


Course No.
BME 461 BME 462 BME 463 BME 464 BME 465 BME 466 BME 467 BME 468 BME 469 BME 561 BME 562

Course Title
Introduction to Nanomaterials Science and Engineering BioMEMS Biochemical Sensors Chemical and Optical Sensors MEMS Design MEMS Systems Evaluation CAD/ CAM Micro/Nano Fabrication Techniques Advanced Topics in BioMEMS Neuroengineering Nanomechanics of Materials and Biomaterials

Cr. Hr.
3 3 3 3 3 3 3 3 3 3 3

Lecture
3 3 3 3 3 3 3 3 3 3 3

Lab.
0 0 0 0 0 0 0 0 0 0 0

Prerequisite or Corequisite
BME 332 BME 422 BME 422 BME 422 BME 422 BME 422 BME 422 BME 422 BME 212 BME 332

Study Plan Guide for the Bachelor Degree in Biomedical Engineering


First Year First Term Course No. GER 101 ENGL 101 MATH 101 PHYS 101 CS 111 BIO 101 MILS 100 Course Title German I English III Calculus I Physics I Computing Fundamentals Biology Military Sciences Total Second Term Course No. GER 102 German II ENGL 102 MATH 102 PHYS 102 ME 111 CHEM 101 IE 121 English IV Calculus II Physics II Comp. Aided Eng. Drawing General Chemistry Workshop Total Course Title Cr. hr. 2 1 3 4 4 3 3 20 Cr. hr. 2 1 3 4 3 4 1 18 Prerequisite Co-requisite GER 101 ENGL 101 MATH 101 PHYS 101 CS 111 Prerequisite ENGL 099 Co-requisite -

Second Year First Term Course No. GER 201 ENGL 201 ENRE 211 BME 212 MATH 201 CPE 225 Course Title German III English V Electrical Circuits Anatomy & Physiology Applied Math for Eng I Organic Chemistry Total Cr. hr. 2 2 4 4 3 4 19 Prerequisite GER 102 ENGL 102 PHYS 102 BIO 101 MATH 102 CHEM 101 Co-requisite -

Second Term Course No. GER 202 German IV ENGL 202 ENRE 213 ME 211 MATH 231 BME 221 ME 222 English VI

Course Title

Cr. hr. 2 2 4 3 3 3 3

Prerequisite GER 201 ENGL 201 ENRE 211 PHYS 101, MATH 102 MATH 102 MATH 201, ENRE 211 MATH 102

Co-requisite -

Fundamentals of Analog Electronics Statics & Dynamics Probability & Statistics for Engineering Biosignals & Biosystems Fluid Mechanics Total

20

Third Year First Term Course No. GER 301 BME 331 CE 341 ENRE 312 CPE 326 Course Title German V Biomechanics Microprocessor & Microcomputer Fundamentals of Digital Electronics Biochemistry University Elective Total Cr. hr. 2 4 4 4 4 3 21 Prerequisite GER 202 ME 211 CS 111 ENRE 213 BIO 101, CPE 225 Co-requisite -

Second Term Course No. GER 302 German VI BME 321 BME 421 CE 211 BME 332 BME 391

Course Title

Cr. hr. 2 4 4 4 4 0

Prerequisite GER 301 BME 221 BME 212, ENRE 312 CPE 225 -

Co-requisite -

Medical Signal Processing Medical Instrumentation I Digital Systems Biomaterials Field Training Total

18

Fourth Year First & Second Terms Course No. Course Title Program Elective 1 Program Elective 1 Program Elective 1 Program Elective 1 BME 499 Practical Trianing Total

Cr. hr. 3 3 3 3 12 24

Prerequisite Dept Approval

Co-requisite -

Fifth Year First Term Course No. IE 353 BME 422 MATH 351 BME 598 ME 343 ARB 301 Course Title Engineering Economics Medical Instrumentations II Numerical Analysis Graduation Project I Automatic Control Systems Advanced Arabic Total Second Term Course No. Course Title BME 599 Graduation Project II NE 101 CS 212 CS 361 National Education Object-Oriented Programming Database Management Systems University Elective Total Cr. hr. 3 4 3 3 4 3 20 Cr. hr. 3 3 4 4 3 17 Prerequisite BME 598 CS 111 CS 111 Co-requisite Prerequisite MATH 201 BME 421 MATH 201 MATH 201 Co-requisite

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Description of Courses offered by Department


BME 212. Anatomy & Physiology (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Biology (BIO 101) Study of the basics of human anatomy and physiology including anatomical terminology, cells and tissues, body membranes, the skeletal system and muscular system. The nervous system, special senses, the cardiovascular system, ECG, the respiratory system, urinary system. BME 221. Biosignals and Biosystems (3 Cr. Hrs) two lectures per week Prerequisite: Electrical Circuits (ENRE 211), Applied Math for Eng I (MATH 201) Principles of biosignal processing. Linear time invariant systems; continuous time systems, application of Laplace and Fourier transforms to medicals linear systems; Discrete time systems; Ztransform; discrete Fourier series and fast Fourier transform; computer applications system function; frequency response and simulation in the frequency domain. BME 311. Health management Systems (3 Cr. Hrs) two lectures per week Prerequisite: Database Management Systems (CS 361) Data and dataflow in hospital, type of data, models of presentation, general ledger, cost accounting, evaluation techniques, budgeting and analysis, material management, inventory control. Introduction to management of health care information systems. Fundamentals, management of information systems, planning of projects, attendance of projects, system analysis, system evaluation, selection of systems, implementation of systems, finishing a project. BME 321. Medical Signal Processing (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Biosignals and Biosystems (BME 221) Acquisition and sampling of Biosignals; Shannon's Theorem, Fourier series and Fourier transform, power spectrum estimation, Wiener's Theorem, correlation techniques, computer aided ECGprocessing in the frequency domain; signal averaging of EP,S; FIR Filter, IIR Filter, and Adaptive Filter ; Filter techniques. Students will use MatLab program as Processing Tools. BME 331. Biomechanics (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Statics & Dynamics (ME 211) Relationship between forces, moments, mass, and acceleration for human body and body segment motions. Centroids, center of mass, mass moment of inertia, and relative motion, mechanics of tissues, joints, and human movement. Basic anatomy and physiology of limb and joint defects, biomechanics, motion analysis, and current device designs. Application of mechanical engineering and biomaterial selection principles in the design of artificial limbs and joints. BME 332. Biomaterials (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Organic Chemistry (CPE 225) A course discusses various aspects pertaining to the selection, processing, testing (in vitro and in vivo) and performance of biomedical materials. The biocompatibility and surgical applicability of metallic, polymeric and ceramic implants and prosthetic devices are discussed. The physiochemical interactions between implant material and physiological environment will be described. The use of biomaterials in maxillofacial, orthopedic, dental, ophthalmic and neuromuscular applications is presented.

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BME 421. Medical Instrumentation I (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Fundamental of Digital Electronics (ENRE 312), Anatomy and Physiology (BME 212) Analysis, and operation of transducers, sensors, and electrodes, for physiological systems; Instrumentation amplifiers. Principles of operation of selected devices: Blood Pressure, Temperature, Flow and Gas measurements devises, pulse oximeter, incubators, electrodes and insulin pump, Monitoring devises, electrocardiogram (ECG) devises, pacemaker and Defibrillation, ventilator and Anesthesia devices, Dialysis machine. Aspects of medical devices performance and accuracy, Patient safety. BME 422. Medical Instrumentation II (4 Cr. Hrs) two lectures per week and three hours of laboratory Prerequisite: Medical Instrumentation I (BME 421) Theory and principles of biosensor design and application in medicine and biology. Analysis and selection of physical, electrical, mechanical, thermal transduction mechanisms, which form the basis of the biosensor design. Principles and fundamental properties of transducers (dynamics, linearity, hysteresis, and frequency range). transducer interfacing and signal conditioning, material biocompatibility, and packing. Selected examples: micro fluidics, bioelectronics, pressure sensors, temperature sensors and electrochemical sensors. BME 423. Magnetic Resonance Imaging (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) This course will first introduce the basic physics of MRI, including magnetic moments and resonance, nuclear spin interactions with applied magnetic fields, and magnetic relaxation. The second portion of the course will discuss basic concepts of image formation, including radiofrequency pulse excitation, magnetic field gradients, imaging equation, Fourier Transform, and two-dimensional spatial encoding. The final portion of the course will introduce practical imaging methods and applications, such as image artifacts, fast imaging methods, signal-to-noise, contrastto-noise, resolution, MR imaging of heart and blood vessels, and MR imaging of the neural system. BME 424. Fundamentals of X-Ray Modalities (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Physics and fundamentals of x-rays, conventional x-ray modality, Computerized Tomography CT modality. Principles of 3D reconstruction from projections in medicine. The mathematics of reconstruction from projections. Application of x-ray's modalities in human body scanning. BME 425. Introduction to Ultrasound Technique (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Physics and fundamentals of Ultrasound. Propagation of ultrasound in heterogeneous media such as tissue, Ultrasound Imaging principles and basic of tissue characterization. Ultrasound Modality including details of A- and B- mode scanners. Simple tissue models based on ultrasound wave absorption and scattering. Ultrasound transducer models, advantages and disadvantages of various transducer configurations. The principles of acoustic output measurements and instrumentation requirements. Electrical and biological effects of ultrasound diagnostics algorithms. BME 426. Medical Image Processing (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) The human visual system, imaging techniques, image quantization, grey value transformations, local filter, 2D Fourier transform, gradient operators, morphological filter, image enhancement, encoding, restoration, and reconstruction, object segmentation , textures, edge detection, thinning algorithms features for classification Image Compression and watermarking. Projects on different medical images are compulsory.

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BME 427. Biosignals processing (3 Cr. Hrs) two lectures per week Prerequisite: Medical Signal Processing (BME 321) This course covers biomedical signal characteristics, biomedical systems, and models, applications of Fourier transform wavelet transforms, and joint-time frequency analysis of biomedical signals. Systems studies include ultrasounds, ECGs CAT scans, MRIs, X-rays, and others. BME 428. Engineering Optics for Medical Application (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Introductory overview of optical phenomena and the optical properties of biological tissue. Fundamentals of optical systems design, integration and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispersion elements optical fiber, detectors. Systems integration: radiometry and interferometer. Optical system analysis: resolution, modulation transfer function, deconvolution, tissue optics and noise. Optical imaging applications in biology and medicine: reflection, refraction, interference, diffraction, polarization, light scattering and fluorescence, and their application in biomedical imaging and microscopy. BME 429. Photomedicine (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Physics and fundamentals of LASER Optical and engineering based systems (laser-based) in diagnosis, treating diseases, manipulation of cells and cell function Medical Devices using LASER. BME 431. Principles of Tissues Engineering (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) and Biomechanics (BME 331) The selection, processing, testing and performance of materials used in biomedical application with special emphasis upon tissues engineering. Topics include material selection and processing, mechanism and kinetics of materials degradation, cell-materials interaction and interface; effects of construct architectures on tissue growth; and transport through engineered tissues. Examples of engineering tissues for replacing cartilage, bone, tendons, ligaments, skin and liver will be presented. BME 432. Advanced Topics in Tissue Engineering (3 Cr. Hrs) two lectures per week Prerequisite: Principles of Tissues Engineering (BME 431) General principles of tissue engineering includes aspects of cell isolation and propagation; matrix selection; construct creation, manipulation, and implementation, and evaluation of resulting repairs. Applications: skin replacement, cartilage tissue repair, bone tissue engineering, nerve regeneration, corneal and retinal transplants, ligaments and tendons, blood. Substitutes artificial pancreas, artificial lever, tissue integration with prosthetics, vascular grafts, and cell encapsulation angiogenesis.

BME 433. Bone Tissue Regeneration (3 Cr. Hrs) two lectures per week Prerequisite: Biomechanics (BME 331) Description of micro- and macro-anatomy of bone, its embryology, and would healing, traditional bone grafting materials. In vitro methods and animal wound models for designing and developing bone regeneration therapies. BME 434. Polymeric Biomaterials (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Basics and applied concepts of polymers as biomaterials. Fundamental synthetic mechanism of polymers and their physical and chemical properties. Biodegradation mechanism, mechanical properties and surface chemistry of polymeric materials. Cellular interactions with various surface and immunological responses. Application of biomaterials include tissue engineering and artificial organs.

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BME 435. Advanced Cardiovascular Biomechanics (3 Cr. Hrs) two lectures per week Prerequisite: Biomechanics (BME 331) The dynamics of the heart and blood vessels. Pulsatile blood flow, microcirculation, and muscle mechanics. Modeling of boundary value problems in cardiovascular engineering. Tissue Engineering in cardiovascular application: Artificial Heart and Blood. BME 436. Biomaterials Tissue Interaction (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Examines the principle of materials science and cell biology underlying the design of medical device, artificial organs and scaffolds for tissue engineering. Molecular and cellular interaction with biomaterials are analyzed in terms of cellular processes such as matrix synthesize, degradation and contraction. Principles of wound healing and tissue remodeling are used to study biological responses to implanted materials and devices. Additionally, this course examine criteria for restoring physiological function of tissue and organs and investigate strategies to design implants and prostheses based on control biomaterial-tissue interactions. BME 437. Tissue Mechanics (3 Cr. Hrs) two lectures per week Prerequisites: Biomechanics (BME 331) Advanced techniques for the characterization of the structure and function of hard and soft tissues and their relationship to physiologic processes. Solid mechanics of prominent musculoskeletal and cardiovascular tissues. Their normal and pathological behaviors (stiffness, strength, relaxation, creep, adaptive remodeling, etc) in response to physiologic loading will be examined and quantified. Application includes: tissue injury, wound healing, the effect of pathological conditions upon tissue properties and design of medical device and prostheses. BME 438. Composite with Biomedical and Materials (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Introduction to fiber/ particulates reinforced, engineered and biologic materials. Focus on elastic descriptions and application of composite materials. The development of constitutive equation that defines the mechanical behavior of a number of applications of emphasized, including: biomaterial, tissue, and materials science. BME 439. Biomaterials in the design of Medical Devices (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Addresses a unique rule of biomaterial in medical device design and the use of emerging biomaterials technology in medical device. The need to understand design requirements of medical devices based on safety and efficacy will be addressed. An expected device failure due to synergistic interactions from chronic loading, aqueous environments and biologic interactions. Testing methodologies to assess accelerated effects of loading in physiologic-like environments. Evaluate biomaterials and their properties as related to design and reliability of medical devices. BME 461. Introduction to Nanomaterials Science and Engineering (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Nanotechnology involves behavior and control of materials and processes at the atomic and molecular levels. This interdisciplinary course introduces the theoretical basis, synthetic processes and experimental techniques for nanomaterials. Introduction to nanostructures, microstructures, macrostructures and functional components of hard and soft tissue as applied to implantable materials, devices and pharmaceutical modalities.

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BME 462. BioMEMS (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Micro and nanosystem used in advanced analytical techniques for microfluidic devices, implantable chips, non invasive biomedical sensors, DNA chips and microelectronic array system. Biomedical sensors and actuators. bioMEMS active ultrasonic transducers for medical imaging, for microvalves and for implantable medication delivery systems are studied. BME 463. Biochemical Sensors (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Biosensors which monitor levels of blood electrolytes for real-time patient management are surveyed in this course. Fundamental principles underlying the transducers that convert chemical activity into electrical or optical signals are studied in depth. Sensitive and selective biological membranes based on ion, enzyme, and immune-reactions. Sensor stability and response time. Other processes involved in the operation of the sensors such as membrane diffusion, capillary transport and cell separation are also covered. Devices for measuring blood gases, electrolytes, hemoglobin, glucose, PH, drugs and other bioactive compounds are also presented. BME 464. Chemical and Optical Sensors (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Theory, design, and applications of chemical and optical sensors used in medical diagnosis, patient monitoring, and Laboratory devices. Electrochemical and optical sensors. BME 465. MEMS Design (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Use of MEMS in biotechnology, instrumentation, robotics, manufacturing and other applications. Synthesize and design high performance MEMS that satisfy the requirements and specifications imposed. Integrated approaches applied to design and optimize MEMS including: integrate microelectromechanical motion devices, ICs, and micro sensors. Recent advances in biomedical applications of MSMS. Course will require a design using CAD tool for a biomedical MEMS-based micro integrated system. BME 466. MEMS System Evaluation (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) General evaluation methodologies. Evaluation of MEMS, micro system and microelectromechanical motion devices utilizing MEMS testing and characterization. Performance evaluation matrices, comprehensive performance analysis and functionality. Applications of advanced software and hardware in MEMS evaluation. BME 467. CAD/CAM (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Selected topics in mechanical design, computer aided engineering computer aided design, computer aided manufacturing and computer integrated manufacturing. Software Design: Mechanical desktop. Computerized Numerical control CNC machine and g-gode programming. BME 468. Micro/Nano Fabrication Techniques (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Overview of semiconductors materials. Semiconductors devices application actuators control system and sensors. Instruction and hands-on semiconductor process in clean-room environment, including two sided wet and dry lithography for microelectronics, micro sensors and MEMS. Micro fabrication principles and elements, epitaxial growth, oxidation, thin film deposition. Lithography, etching, doping and LIGA micromachining and process integration.

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BME 469. Advanced Topics in Bio MEMS (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation II (BME 422) Genome sequencing, gene expression measurements and applications: programmable DNA/ molecular for sequencing and diagnostics, biomaterials and self- assembled nanostruction for biosensors and drug delivery. BME 499. Practical Training (12 Cr. Hrs) six months in Germany Prerequisite: Complete ? credits and Department approval Students will practice their knowledge for about 6 months in various hospitals, labs and associations. It is understood that specialized training in the workplace for graduates to fulfill more advanced requirements of the job. Their educational training however, should provide them with a strong knowledge and skill background that serves as a foundation for easy transition into specialized applications encountered in the workplace. BME 511. Cell Matrix Mechanics (3 Cr. Hrs) two lectures per week Prerequisite: None Mechanical properties and behavior of the cell, cellular structures, and the directs cellular environment. Mechanically relevant structure of the cell and the extracellular matrix. Visualization and manipulation of cells with Atomic Force Microcopy and Confocal Laser Scanning Microscopy. Mechanical properties of cell structures and extracellular matrix components. Mathematical models to describe the (dynamics) mechanical behavior of cells ranging from tensegrity models of the cytoskeleton to multi-level FE models of groups of cells in their extracellular environment. Mechanotransduction and gene expression in response to mechanical stress. The major hypotheses on mechanotransduction pathways in the cell are discussed. BME 521. Reliability and Security of Medical Devices (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Identification and verification reliability element indices and systems for various model types partition period to the failure and between failures with respect on medical instrument specifies, warranty of patients safety and medical device service Reliability exams, statistic acceptance of reliability, preventive maintenances systems of reliability operation exams. BME 522. System Safety (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Physiological effects of electricity Inductive methods for analyzing systems to recognize, evaluate, and control hazards. Techniques include preliminary hazard analysis, failure mode and effects analysis, protection and equipment design. Safety analyzer and lest of devices for safety. BME 523. Fiber Optics (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Introduction to fiber optics, review of communication systems and light wave fundamental. The study of dielectric waveguides and optical fibers, light- emitting diodes(LEDs) laser diodes and photo detectors, discussion of optical fiber communication systems with special attention to noise sources in optical receivers, lit error rate and power budget. BME 524. Biorobotics (3 Cr. Hrs) two lectures per week Prerequisite: Statics & Dynamics (ME 211) Topics include biomimetic design (why nature and humans design differently), sensors (touch, stereo and position), actuators (muscles, smart materials), and intelligent (neural and computer controlled) systems. Also it will cover the application of robotics medicine.

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BME 525. Biological Basis of imaging (3 Cr. Hrs) t two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Study Physical properties of tissues that determine the nature of the information obtainable by Imaging Technique. Establishing a strong connection between the methods of imaging and the underlying biological processes that give rise to image information is the overall goal of this class. This course provides the background by which students will learn not only what biological properties affect the signals used to construct images but also how various imaging approaches may be used to understand biological processes. BME 526. Quantitative Functional Imaging (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) This course emphasizes the technical aspects of making quantitative measurements of structure and function using different imaging methods, including special imaging methods as well as approaches to image analysis algorithms, and the use of modeling or data analytic techniques for assessing function. BME 527. Laser/Tissue Interaction (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) The optical behavior of random media in interaction with laser irradiation. Approximate transport equation methods to predict the absorption and scattering parameters of laser light inside tissue., measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Portwine stain treatment; cancer treatment by photo chemotherapy, cardiovascular applications. Computer simulations of light propagation in tissue. BME 528. Introduction to Ionizing Radiation (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Covering the basic principles of radiation and the interaction of radiation with matter, with particular attention given to radiation detection and measurement. Discusses natural and man-made radiation sources, energy deposition and dose calculations, various physical, chemical, and biological processes and effects of radiation with examples of their uses, and principles of radiation protection. Throughout the course emphasis is placed on the underlying physics and the technical issues that impact image quality. BME 529. Fundamentals of Computer Tomography (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) The development of Computed Tomography, X-ray detectors, X-ray linear attenuation coefficient, Type of Scanning (Fan Beam Fixed and Rotating detector, Scanning electron beam, spiral scanning) , Data acquisition, Reconstruction principles, artifact and reconstruction error, patient dose consideration. BME 531. Human Anthrometric and Physical Measurements (3 Cr. Hrs) two lectures per week and three hours of laboratory Perquisite: Biomechanics (BME 331) Engineering aspects of the human Body Parts Measure. Find patterns and symmetry in human body. Applied these aspects to Biomechanics Science and Biomechanics design. Used international standard Measurement table of the human Body. BME 532. Occupational Biomechanics (3 Cr. Hrs) two lectures per week Perquisite: Biomechanics (BME 331) Advanced study of biomechanical and physiological modeling and measurement techniques useful in the study and mitigation of physical stressors in the industrial workplace and study cumulative trauma disorders and slip fall prevention applied to the organization.

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BME 533. Surgery for Engineers (3 Cr. Hrs) two lectures per week Prerequisite: Medical Instrumentation I (BME 421) Fundamental skills and principles of surgery devices. Operating rooms design and sterilization. Computer assisted surgery technologies, including surgical navigation, image guidance and robotic surgery. BME 534. Biomechanics of Hard Tissues (3 Cr. Hrs) two lectures per week Prerequisite: Biomechanics (BME 331) Structure property relationships for mineralized connective tissues of human body. Discussion centers on various types of bone (e.g lamellar, woven) and teeth with an emphasis on modeling for biomechanical behavior, both in vitro and in vivo. Topics include elastic models for born (isotropic and anisotropic), theories of yielding and fatigue, strength properties, composite and hierarchical models, and models of bone remodeling/modeling. BME 535. Artificial Organs (3 Cr. Hrs) two lectures per week Prerequisite: Principles of Tissues Engineering (BME 431) Engineering aspects of artificial organ design. Artificial kidney, lungs, hearts, eyes, livers, and pancreases. Extracorporeal cellular immunotherapy. BME 536. Drug Delivery (3 Cr. Hrs) two lectures per week Prerequisite: none Engineering principle and biological considerations in designing drug delivery systems for medicals uses. The concept of biocompatibility and its implication in formulation controlled release devises are illustrated. Emphasis on the use of biodegradation materials to design drug delivery systems for site-specific applications. BME 537. Theoretical & Applied Polymer Science (3 Cr. Hrs) two lectures per week Prerequisite: None An advanced course in materials science and engineering dealing specifically with the structure and properties of polymers. Particular attention paid to recent developments in the processing and use of modern plastics and fibers. Product design considered in terms of polymer structures, processing techniques, and properties. BME 538. Transport Phenomena in Cells and Organs (3 Cr. Hrs) two lectures per week Perquisite: Fluid Mechanics (ME 222), Biochemistry (CPE 326) Applications of the principles of mass and momentum transport to the analysis of selected processes of biomedical and biotechnological interest. Emphasis on the development and critical analysis of models of the particular transport process. Topics include: reaction-diffusion processes, transport in natural and artificial membranes, dynamics of blood flow, pharmacokinetics, receptormediated processes and macromolecular transport, normal and neoplastic tissue. BME 539. Biotechnology and Bioprocess Engineering (3 Cr. Hrs) two lectures per week Prerequisite: None Introduction to the engineering principles of bioprocess engineering. Topics include: introduction to cellular and protein structure and function, modeling of enzyme kinetics, DNA transcription, metabolic pathways, cell and microbial growth and product formation, bioprocess operation, scaleup, and design. Class includes a design project. BME 552. Tenders & Technical Specification (3 Cr. Hrs) two lectures per week Prerequisite: None Students will able to write Tenders and Technical Specification for medical device (the correct level of detail, Information find quickly and efficiently), Bid writing(giving tight deadline).

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BME 553. Biomedical Ethics and Safety (3 Cr. Hrs) two lectures per week Prerequisite: None Introduces the wide spectrum of ethical, regulatory, and legal issues facing health care practitioners and health- related research workers. Helps students become aware of the ethical and legal issues involved in their work. Helps students understand how legal and ethical decisions should be made in health-related matters, as well as what sources of help and guidance are available. BME 561. Neuroengineering (3 Cr. Hrs) two lectures per week Prerequisite: Anatomy and Physiology(BME 212) Introduces the theory of neural signaling. Students will learn the fundamental theory of cellular potentials and chemical signaling, the Hodgkin Huxeley description of action potential generation, circuit representations of neurons and be able to derive and integrate equations describing the circuit as well as design computer models. BME 562. Nanomechanics of Materials and Biomaterials (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) Latest scientific developments and discoveries in the field of nanomechanics, i.e. the deformation of extremely tiny (10-9 meters) areas of synthetic and biological materials. Lectures include a description of normal and lateral forces at the atomic scale, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of individual macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors. BME 563. Prosthetics and Orthotics (3 Cr. Hrs) two lectures per week Prerequisite: Biomaterials (BME 332) This is an introductory course in the designing and evaluation of prosthetics (artificial limbs), and orthotics (braces and splints).Biocompatibility of materials used in Orthopedic and dental applications. BME 564. Movement Biomechanics and Rehabilitation (3 Cr. Hrs) two lectures per week Prerequisite: Biomechanics (BME 331) Biomechanics for the design and evaluation of artificial devices intended to restore or improve movement lost due to injury or disease. Measurement technique in movement biomechanics, including motion analysis, electromyography, and gait analysis. Design and use of upper and lower limb prostheses. Principle of neuroprostheses with applications to paralyzed upper and lower extremities. BME 565. Biomechanics of Soft Tissues (3 Cr. Hrs) two lectures per week Prerequisite: Biomechanics (BME 331) Applications of continuum mechanics in modeling the biomechanical behavior of nonmineralized tissues such as tendons, ligaments, skin, cartilage, blood, vessels , ets. Topics include structure of collagen, elastin proteoglycans, and other tissue components, nonlinear elastic models (including Fungs pseudoelasticity approach and strain energy functions), linear viscoelasticity, Fungs quasilinear viscoelasticity, herhditray formulation of constitutive equations, and introduction to mixture theory. BME 598. BME 599.Graduation Project I and II (3 Cr. Hrs each) two semesters Prerequisite: Department Approval Biomedical students discuss a medical problem in their specialized field and try to provide solution to it either hardware or software or both. Also students are able to develop or design new simple medical devices.

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