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2009

M U
T khi hnh thnh s sng, loi ngi phi i mt vi rt nhiu nguy him e da cuc sng. Mt trong nhng nguy c l bnh tt. V c th chng li c bnh tt, t trc cng nguyn, con ngi bit s dng cc loi cy c cha mt s loi bnh. Khi cuc sng cng ngy pht trin, khoa hc cng ngh cng nhiu cc pht minh phc v cuc sng con ngi th i km theo cng l s gia tng ca cc loi bnh tt. V vy thuc l yu t khng th thiu c trong phng v iu tr cc bnh tt c qu kh, hin nay v tng lai. nc ta, tuy ngnh cng nghip dc hnh thnh mun so vi cc nc khc trn Th Gii nhng cng ang tng bc pht trin. Hin nay trn c nc c nhiu cng ty sn xut thuc ra i t tiu chun GMP-WHO. Tuy i a s cc cng ty mi ch dng li giai on bo ch cc sn phm v ch mt s t cc cng ty c phn xng ho dc nhng tin ti ngnh cng nghip dc s pht trin c cng ngh sn xut cc nguyn liu phc v cho sn xut. y l t thc tp cui cng chun b hnh trang trc khi ra trng ca sinh vin lp Cng ngh Ho dc v HCBVTV nn rt quan trng v b ch cho chng em. t thc tp ny gip chng em c ci nhn tng quan hn na v thc t sn xut v l thuyt hc thng qua qu trnh tham quan 3 cng ty: Cng ty C phn Dc phm Trung ng I. Cng ty C phn thuc st trng Vit Nam VIPESCO. Cng ty C phn Dc phm Trung ng Mediplantex.

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Em xin chn thnh cm n TS. Nguyn Tun Anh tn tnh lin h v gip chng em trong t thc tp ny, tuy ch l mt thi gian thc tp ngn nhng em cng thu thp c cc thng tin phc v cho cng vic sau ny.

MC LC
M U...................................................................................................................1 MC LC.................................................................................................................2 PHN I: HIU BIT CHUNG V GMP.................................................................5 I. NH NGHA...................................................................................................5 2

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II. NGUYN TC V NI DUNG CA GMP..................................................6 i. Nguyn tc c bn ca GMP...........................................................................6 ii. Nm yu t quan trng ca GMP...................................................................6 iii. Ni dung chnh ca GMP..............................................................................7 iv. Chin lc m bo ton din cht lng.....................................................7 PHN II:CNG TY C PHN DC PHM TRUNG NG I........................8 I. GII THIU V CNG TY .............................................................................8 1. Gii thiu chung:............................................................................................8 ii. Hot ng:....................................................................................................10 iii. C cu t chc:............................................................................................10 iv. Sn phm v th trng:..............................................................................12 II. PHN XNG SN XUT THUC KHNG SINH.................................14 1. S phn xng.........................................................................................14 2. Thuyt minh s .......................................................................................17 PHN III: CNG TY THUC ST TRNG VIT NAM...................................19 I. GII THIU CHUNG......................................................................................19 1. Sn xut........................................................................................................20 ii. Nghin cu v pht trin..............................................................................22 iii. Hp tc quc t............................................................................................23 II. MT S CNG NGH SN XUT CA CNG TY................................23 1. Dy chuyn sn xut ng oxy clorua.........................................................23 ii. Dy chuyn gia cng cc sn phm thuc dng dung dch hoc thuc dng bt: 25 iii. H thng x l kh thi.................................................................................27 PHN IV: CNG TY C PHN DC PHM MEDIPLANTEX....................30 3

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I. GII THIU V CNG TY............................................................................30 1. Nng lc nhn s v k thut:......................................................................30 ii. Nng lc kinh doanh....................................................................................31 iii. Nhng thnh tu ni bt gn y................................................................32 iv. Phm vi hot ng ......................................................................................33 v. C cu t chc..............................................................................................35 II. PHN XUNG SN XUT.........................................................................35 1. Yu cu v GMP...........................................................................................36 ii. C cu t chc v dy chuyn sn xut ca xng GMP............................37 III. KIM TRA CHT LNG.........................................................................40 IV. CC H THNG PH TR........................................................................41 1.X l nc:...................................................................................................41 2.iu ha khng kh:.....................................................................................42 3.X l nc thi:............................................................................................42 V. CC SN PHM CA CNG TY..............................................................43 KT LUN.............................................................................................................45

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PHN I: HIU BIT CHUNG V GMP


I. NH NGHA
Thc hnh sn xut thuc tt (GMP: Good Manufacturing Practices) l h thng nhng quy nh chung hay hng dn nhm m bo cc nh sn xut c th cho ra sn phm lun lun: - t tiu chun cht lng ng k. - An ton cho ngi s dng. - Mc tiu p dng ca GMP. Trong qu trnh sn xut thuc, c nhiu yu t nh hng n cht lng ca thuc nh tnh trng ln xn, nhm ln hay ly nhim cho. Vic kim tra cht lng thuc c th b hn ch v: - Ch kim tra mt s mu i din cho l sn xut. - Kh nng ca phng php hay thit b kim nghim c hn. Nh sn xut thuc cn tho mn yu cu ca khch hng xong phi chp nhn nhng qui nh v qun l dc ca b y t. Nu thuc c cht lng km th ngi s dng thuc s b thit thi hay nguy him n sc kho, ngi k n b mt uy tn v suy cho cng th nh sn xut phi chu trch nhim. Do mc tiu p dng ca GMP l gip cho cc nh sn xut thuc phng nga nguy hi gim thiu cc yu t nh hng n cht lng thuc trong qu trnh sn xut. y khng ch l trch nhim ca nh sn xut thuc m cn ph thuc vo ch trng ca b y t.

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Bo co thc tp tt nghip II. NGUYN TC V NI DUNG CA GMP


i. Nguyn tc c bn ca GMP 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Vit ra nhng g cn lm. Lm theo nhng g vit. Ghi kt qu lm vo h s. Thm nh cc quy trnh. S dng hp l cc thit b. Bo tr thit b theo k hoch. o to thng xuyn v cp nht. Gi gn sch s v ngn np. Cnh gic cao v cht lng. Kim tra s thc hin ng.

2009

ii. Nm yu t quan trng ca GMP 1. 2. 3. 4. 5. Mi trng. Nguyn liu . Con ngi. Quy trnh. Thit b.

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iii. Ni dung chnh ca GMP 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Khi nim. Nhn s. Nh xng. Thit b. V sinh. Sn xut. Cht lng. T thanh tra. X l khiu ni. Ti liu. iv. Chin lc m bo ton din cht lng.

2009

Theo quan nim v cht lng ton din, ngnh dc cc nc c xu hng p dng ng b thc hnh sn xut thuc tt (GMP), thc hnh kim nghim thuc tt (GLP), thc hnh bo qun thuc tt (GSP), thc hnh phn phi thuc tt (GPP). T nm 2002, b y t Vit Nam c cc ch trng v hng dn v GMP, GLP v GSP. Quy trnh thao tc thuc chun (SOP- Standard Operating Procedure) l mt vn bn trnh by mt cch trnh t v cc thao tc trong mi hot ng ca mt nh sn xut. th d: kim nh dng c, ly mu nguyn liu hay thnh phm, lm v sinh thit b hay nh xng, vn hnh thit b sn xut, kim nghim hay n nh ngy sn xut. 7

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Vic p dng h thng SOP c th gip nh sn xut ngn nga hay gim thiu cc tnh trng sai st, ln xn v nhim cho.

PHN II:CNG TY C PHN DC PHM TRUNG NG I


I. GII THIU V CNG TY
1. Gii thiu chung: Tn doanh nghip: Cng ty dc phm trung ng I Tn vit tt hay tn giao dch: PHARBACO Hnh thc: Cng ty c phn. Nm thnh lp: 1955 S giy php: 401/ BYT/ Q ngy 20/5/1993 S ng k kinh doanh: 108249 a ch: 160 Tn c Thng- ng a- H Ni

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Trong thi k khng chin chng Php, nhu cu thuc phc v cho khng chin ngy cng cao, nh nc ta quyt nh thnh lp Vin bo ch Trung ng vi nhim v sn xut thuc phc v khng chin c c s t ti ph Ph Don. Trong thi k chin tranh chng Php din ra c lit, Vin c chuyn ln chin khu Vit Bc v sau ngy ho binh lp li nm 1954 c chuyn v H Ni. Nm 1955 chuyn ton b c s t ph Ph Don v 160 Tn c Thng- ng a,c st nhp thm cc n v v i tn thnh X Nghip I vi nhim v sn xut thuc men, bng bng v cc vt t Y t phc v khng chin chng M cu nc v phc v nhn dn. Do nhim vuh sn xut a dng, s lng mt hng nhiu nn m bo tnh chuyn mn nm 1961 X Nghip I tch thnh 3 X nghip: X nghip Dc phm I: Chuyn sn xut thuc Tn dc. X nghip Ho dc: nay l Cng ty c phn Ho Dc H Ni: sn xut cc ho cht lm thuc v mt s vt t y t. X nghip Dc phm III nay l Cng ty c phn dc phm III ti Hi Phng. Nm 1993, X nghip dc phm I i tn thnh X nghip dc phm Trung ng I, v nm 2007 theo quyt nh s 286/Q-BYT ngy 25/01/2007 v quyt nh s 2311/Q-BYT ngy 27/06/2007 ca B trng B Y T, X nghip c chuyn thnh Cng ty c phn Dc phm Trung ng I Pharbaco. T ngy thnh lp n nay doanh nghip lun l con chim u n ca ngnh cng nghip Dc Vit Nam v cng ty c nh nc tng thng nhiu hun huy chng cc loi. Hin ti cng ty c 2 c s :

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* C s 1 ti 160 Tn c Thng: Cng ty hin c: 03 dy chuyn t tiu chun GMP ASEAN 01 phng kim nghim t tiu chun GLP v h thng kho t tiu chun GSP. * C s 2 ti Sc Sn - H Ni: Cng ty ang u t xy dng v hon thin Nh my mi hin i, dy chuyn thit b Chu u, t cc tiu chun GMP - WHO, GLP, GSP. ii. Hot ng: Hin ti cng ty ang hot ng sn xut, mua bn, xut nhp khu nguyn, ph liu lm thuc, dc phm, ho cht ( Tr ho cht Nh nc cm), m phm, thc phm, vt t v my mc thit b sn xut dc phm v y t. T vn dch v khoa hc, chuyn giao cng ngh trong lnh vc y dc. Xy, dng qun l, khai thc cc cng trnh cng nghip v dn dng. T vn u t trong v ngoi nc( Khng bao gm t vn php lut, ti chnh) iii. C cu t chc: Tng Gim c : inh Xun Hn : Tng gim c - Thc s dc hc - C nhn kinh t S t chc

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Hnh 1: S t chc Pharbaco Pharbaco c i ng cn b cng nhn vin vi trn 100 dc s, c nhn c trnh i hc v trn i hc, trn 100 dc s trung cp v trn 300 cng nhn k s lnh ngh. Vi i ng cn b tr nng, ng sng to v nhit tnh, cc sn phm ca 11

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cng ty rt phong ph a dng vi 59 sn phm c ng k bo h nhn hiu hng ho. Mt s thng hiu thnh cng p ng yu cu ngy cng cao ca khch hng. Do Pharbaco lung ng trong Top 100 thng hiu mnh Vit Nam,10 nm lin t danh hiu Hng Vit Nam cht lng cao. iv. Sn phm v th trng: Pharbaco c i ng Dc s, cng nhn: gii v chuyn mn, tm huyt, lnh ngh trong lnh vc sn xut v nghin cu sn phm. Hin ti Pharbaco sn xut v lu hnh trn 200 sn phm gm cc nhm thuc khng sinh, thuc h st gim au, thuc tim mch, thuc chng lao, chng st rt, cc vitamin, thuc chng tiu ng vi cc dng bo ch khc nhau: vin nang, vin nn, vin bao film, vin bao ng (trn 2 t vin/nm); thuc bt tim (chc triu l/nm), thuc tim dung dch (50 triu ng/nm) Cc sn phm thuc ca Pharbaco c sn xut trn dy truyn my mc thit b hin i cng ngh tin tin, cng xut ln v h thng kim sot cht lng t tiu chun GMP WHO. c bit Pharbaco c cc dy chuyn ring bit sn xut cc loi khng sinh nhm - lactam nh: Dy chuyn sn xut thuc bt, cm, vin nn, vin bao, vin nang cng cha khng sinh nhm penicillin. Dy chuyn sn xut thuc bt, cm, vin nn, vin bao, vin nang cng cha khng sinh nhm Cephalosporin. Dy chuyn sn xut thuc bt tim cha khng sinh nhm Cephalosporin. Ton b sn phm sn xut trong nh my c kim nghim y v chnh xc nh c mt phng Kim nghim GLP vi y cc phng tin trang thit b

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hin i tr gi hng chc t ng v i ng kim nghim vin lnh ngh, nhiu kinh nghim, thng xuyn c b tc nghip v. Tng kho GSP vi dung tch cha 10000 m3 c trang b h thng iu ho nhit c th kim sot t ng nhit v m m bo cho vic bo qun sn phm theo ng yu cu cht lng. H thng gi k, xe nng hin i p ng nhanh chng vic cp pht hng ho trnh nhm ln. m bo hng ho n tay khch hng y nhanh chng, chnh xc vi cht lng tt nht. Sn phm ca Pharbaco c mt ti 64/64 tnh thnh c nc t Lng Sn n Mi C Mau, c 6 Chi nhnh v i l giao dch trc tip 200 khch hng trn ton lnh th Vit Nam, ng thi Pharbaco c hp ng phn phi sn phm thng qua hng trm Cng ty dc trn ton quc.Cc sn phm thuc ca Pharbaco hin c mt ti cc c s khm cha bnh trn ton quc v nhiu bnh vin ln trung ng cng nh a phng. Ngoi vic cung ng thuc cho h iu tr trong c nc bng cc h thng chi nhnh, i l v cc Cng ty phn phi, Pharbaco cn cung ng cho c th trng ngoi nc.n nay khong 30 sn phm ca Pharbaco c visa xut khu sang mt s nc trn th gii nh Moldova, Papua New Guinea, Nigeria, Somali, Myanmar, Campuchia, Lo. V Pharbaco c cc Cng ty i din phn phi thuc ti cc nc Campuchia, Nigeria, Moldova, c vn phng i din ti Myanmar. Pharbaco vn ang tip tc tm kim v m rng th trng xut khu sang Trung ng, Chu u v Chu Phi. Pharbaco sn xut trn 100 mt hng gm cc loi khng sinh, vitamin, thuc tim mch, thuc chng st rt, thuc chng lao vi cc dng bo ch khc nhau nh vin nang, vin nn, vin bao, hn dch, thuc tim bt, thuc tim dch Sn lng 13

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hng nm ca Pharbaco t trn 2 t vin, 50 triu ng thuc tim v hng chc triu l thuc tim bt cc loi.

II. PHN XNG SN XUT THUC KHNG SINH


Cng ty c cc dy chuyn ring bit sn xut cc loi thuc khng sinh nhm -lactam nh khng sinh h penicilin, cephalosporin hay khng sinh Non lactam ( ang xy dng Sc Sn). Do thi gian thc tp c hn nn chng em ch c th tham quan v tm hiu c phn xng sn xu thuc vin Penicilin. 1. S phn xng Phn xng gm c 40 phng nh. mi mt phng c mt chc nng ring. S phn xng sn xut:

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Hnh 2: Phn xng sn xut thuc vin Penicilin Gii thch: 1. 2. 3. 4. 5. 6. Phng IPC 7. 8. 9. Phng trn Nho cao tc Sy tng si Nguyn liu ch sn xut Thay bao b PVC foil casure. Cn nguyn liu ch sn xut Cn s ch nguyn liu

2009

10. Ra sy dng c 11. Bn thnh phm ch dp vin 12. Kho dng c +t in 13. Kho thng sch 14. Dp vin 1 15. Dp vin 2 16. ng nang 1 17. ng nang 2 15

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18. Bao film 19. Bn thnh phm ch p v, ng l 20. Lau vin nn 21. Lau vin nang 22. Sn xut iu kin c bit 23. p v 1 24. Sy l 25. ng vin vo l 26. p v 2 27. Kho thnh phm cha ng gi 28. Thay qun o khu vc ng gi 29. ng gi 30. Bit tr thnh phm 31. Ra l 32. Vn phng phn xng 33. t trang 34. Thay qun o n 35. Thay qun o nam 36. My lnh

2009

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37. Kh nn 38. Ph tr sy tng si 39. In phun 2. Thuyt minh s .

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y l phn xng c nhim v sn xut thuc Penicilin dng vin. Phn xng t tiu chun GMP Asean v tiu chun sn xut thuc bt h -lactam. Trong phn xng ny nguyn liu cng nh nhn vin u phi tun theo nhng quy trnh v sinh nht nh trc khi vo phn xng sn xut. Nhn vin phi mc qun o, i m, i giy bo h lao ng theo quy nh. Nguyn liu thuc c i theo mt li ring. Bao b ng gi, chai l, nhn mc cng c mt ng ring vo phn xng sn xut. sn xut c mt sn phm thuc vin c cc cng on:
Pha ch Dp vin (ng nang) Bao Phim ng gi

Hnh 3: Cc cng on sn xut thuc vin Pha ch: Nguyn liu ban u gm dc cht chnh v cc t dc c a vo phng 4 cn chia l, chia m sau sang phng ch chuyn sang cng on tip theo. Nguyn liu cho tng l sn xut c a sang phng 5 cn s ch nguyn liu. Sau khi dc cht v t dc c cn lng th c trn u vi nhau phng 7 ri ch nho to ht. Tu tng loi nguyn liu m s dng cch to ht kh hay to ht t. 17

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2009

Vi cc loi thuc nang th dng phng php to ht kh bng mt to ht kh. Vi cc loi thuc vin th phi to ht t bng cch a nguyn liu vo my nho cao tc ( 8), nguyn liu gm dc cht, t dc c trn ln vi nhau cng vi cht dch kt dnh c nho trn vi vi nhau tc cao to thnh mt hn hp t ng nht. Sau hn hp ny c sy bi my sy tng si (9) lm kh v to cm. V sau khi sy cc ht to thnh khng ng nht m c ht to, ht b do phi a vo my sa ht to ht theo mun ri c bao trn to s ng nht l hoc bao vin t dc. Cm c bit tr kho ( 11). Trong kho c hai khu vc ring bit l khu vng (dn nhn vng) v khu xanh (dn nhn xanh). Cm va pha ch xong c a vo kho v t khu xanh sau c a mu i kim nghim, nu t cc tiu chun kim nghim th c dn nhn xanh v chuyn sang vng xanh ch cng on tip theo, nu khng t yu cu th li chuyn v cng on trc pha ch li. Dp vin: Bn thnh phm t yu cu c a i dp vin bng cc my dp vin ( 14,15) v ch bao phim. ng nang: Vi cc loi thuc nang nh Amoxifcilin 0,5g th bn thnh phm c ng vo nang bng cc my ng nang ri cng c lau nang (21) lau ht bi v a vo kho bit tr 19. Bao phim:

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Vi thuc vin sau khi p vin cn c mt cng on ht sc cn thit l bao phim. cng on ny vin thuc c a vo my bao phim bao mt lp phim mng khong vi micromet. Lp phim mng ny c vai tr che giu mi v tht ca thuc, to cm gic d ung hoc iu chnh s ho tan ca vin thuc d dy hay rut. Sau thuc c a qua cng on lau vin (20) lau ht bi bm trn vin thuc ri a vo kho bit tr ch p v hoc ng l (19) ng gi: C hai cp ng gi l ng gi cp I v ng gi cp II: ng gi cp I : bao gm cc cng on nh p v hoc ng l. giai on ny sn phm c ng gi v tip xc trc tip vi bao b. Vi cc loi thuc v th vin nn hoc vin nang c a vo cc my p v ng thnh cc v thuc. Cn vi cc loi thuc c ng trong l th thuc cng c a vo cc my ng l ng vin vo l. ng gi cp II: l qu trnh xp v vo hp, dn nhn cho l v ng vo hp trc khi phn phi.

PHN III: CNG TY THUC ST TRNG VIT NAM


I. GII THIU CHUNG
L mt thnh vin ca Tng Cng ty Ho cht Vit nam, Cng ty Thuc st trng Vit Nam c thnh lp nm 1976, do s st nhp v sp xp li cc x nghip cng ngnh. Cng ty bao gm c s sn xut - nghin cu - trin khai, qung b Tip th v mng li phn phi ti khp ni trong nc. Tr s chnh ti Thnh ph H Ch Minh, Cng ty c vn phng i din H ni, Hu, Bnh dng m bo s hot ng thng xuyn trong ton quc. 19

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Sau 25 nm tn ti v pht trin, Cng ty c nhiu bc chuyn bin quan trng: Sn phm ngy cng a dng, phong ph c hiu qu cao v hin l nh cung cp c uy tn v quen thuc nht vi nng dn. Mt s sn phm c xut khu. 1. Sn xut Vi hai nh my sn xut hot cht, su x nghip gia cng t Bc vo Nam, Cng ty Thuc st trng Vit Nam c th sn xut hng nm t 30 n 40.000 tn thnh phm bao gm cc loi thuc tr su, tr bnh, tr c di, bo qun kho tng, kch thch t thc vt dng bt, ht, nc, nh du, vin trn cc dy chuyn cng ngh c ci to hoc nhp t nc ngoi. Sn xut hot cht: c tin hnh ti Cng ty Lin doanh Kosvida (Kosvida Agrochemical Companny Ltd.) mt lin doanh gia Cng ty Thuc st trng Vit Nam, Cng ty Kosco v Cng ty Daewoo vi cc sn phm BPMC (95% min), Carbofuran (97% k thut), Glyphosate (62% DD, 41% DD), Isoprothiolan (96% min). Cng sut chung: 2000 T/nm. T nhng hot cht ny, c th gia cng thnh hng vn tn thnh phm. Thuc tr su: L nhm sn phm chim t l ln nht trong s cc sn phm ca VIPESCO. Vi hng chc chng loi khc nhau, chng c th dit hu ht cc loi su hi nhng cy lng thc, rau qu v cy cng nghip. Thuc tr nm bnh: Bnh cy trong iu kin kh hu nhit i gy hi khng km so vi su bnh, c bit l khi pht trin thnh dch, gy mt ma trn din tch rng. V sn lng, hin nay truc tr nm bnh ng hng th hai trong s cc sn phm ca VIPESCO, tp trung vo vic tr bnh o n v bnh kh vn cho la l hai bnh ph bin hn c. 20

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nng cao tnh chn lc v gim tc dng c hi i vi mi trng, Cng ty trin khai lin doanh sn xut thuc tr nm bnh vi sinh Validamycin cng sut 3000 tn/nm, c kh nng xut khu. Thuc tr c: Theo d kin trong tng lai thuc tr c s tng nhanh trong VIPESCO t u tin cho thuc tr c vo cy lng thc chnh l la. Cng ty nng cao t l cht tr c trong b sn phm ca mnh phc v cho vic pht trin kinh t trang tri v trng cy n qu. Bn cnh thuc st trng nng nghip VIPESCO cn sn xut cc loi thuc bo v kho tng v thuc st trng gia dng. Thuc bo v kho tng nhm khng ch nhng tn tht sau thu hoch v bo qun cc kho hng ho xut nhp khu, gy ra ch yu do chut v cn trng trong kho. Hai mt hng quen thuc, c hiu qu cao v c sn xut theo cng ngh ca Cng ty i t nguyn liu trong nc l FOBEKA v PHOSTOXIN. Cc loi thuc ny tng tham gia dp tt c dch chut ph la trong nhiu nm r ln min Bc cng nh min Nam. Cht xng hi tr mi mt trong cc kho thc phm khng li d lng c trong thc phm. Thuc st trng gia dng gm cc sn phm dit cn trng trong nh nh rui, mui, gin, kin - nhng k trung gian truyn bnh nguy him. Chng c gia cng di cc dng thun tin cho vic s dng nh nhang, bnh xt, du, vin phn Nhang v bnh xt dit cn trng trong nh nhn hiu Mosfly l sn phm lin doanh ca VIPESCO v MALAYSIA, c tn nhim cao trong nc nh hiu qu v an ton. Ngoi cc sn phm ch yu c sn lng ln, VIPESCO cn trin khai mt s sn phm khc phc v vic trng trt, l: 21

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Bo co thc tp tt nghip

2009

Cht iu ho sinh trng cy trng: c tc dng y nhanh s sinh trng, ra r, hoa, t l th phn (u qu) v cht lng sn phm. nhiu nm qua, cc mt hng nh VIPAC 88, VIPROM, VIKIPI v VIMOGREEN c tn nhim vi khch hng. Chng c dng s l ht ging cng nh phun ln hoa v tc ng r rt n nng xut. Phn bn l: Cung cp cc cht dinh dng v c bit cc nguyn t vi lng di dng d hp th, qua h thng l cy, khng nhng lm cho cy pht trin nhanh hn, cht lng sn phm cao hn m cn hn ch c cc bnh.hi cy. Phn bn l dng cho la, cc loi rau - qu c tim nng th trng ln trong tng lai. ii. Nghin cu v pht trin c th m rng v sn xut , a dng ha sn phm khng th thiu cng tc nghin cu - trin khai, do trung tm Nghin cu sn xut ho cht nng dc phm. vi i ng cc nh khoa hc tr v trang thit b tng i hin i, cng nh cc thit b sn xut quy m nh, trung tm nghin cu cc hot cht mi, c hiu qa cao, tc dng chn lc nhng nhanh chng phn hy trong iu kin t nhin, khng li d lng c; cc cng thc pha ch theo hng gim s dng cc dung mi hu c tc ng xu n mi trng; cc dng gia cng thch hp t gy nhim. trung tm cng c bit ch n vic pht trin sn phm mi nh cht iu ha sinh trng, phn bn l, cc ph gia v cht n, cht hp dn, cht xua ui, nng dc sinh hc. qua khu th nghim ln v qung b, nhng sn phm mi no c th trng chp nhn s nhanh chng c sn xut trn quy m ln.

22

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
iii. Hp tc quc t

2009

VIPESCO c mi quan h rng ri vi nhiu i tc quc t. Nhng mi quan h ca Cng ty khng ch l quan h thng mi m cn l quan h cng ngh. Chng ng vai tr quan trng trong vic i mi cc cng ngh, p dng cc dy chuyn sn xut tin tin, a dng ho v nng cao cht lng sn phm. Vic thnh lp cc Cng ty lin doanh nh Kosvida vi Hn quc, Viguato vi Trung quc, Mosfly Vit nam vi Malaysia l dn chng v hiu qu ca vic hp tc quc t. Xc tin ngoi thng l mt trong nhng u tin ca VIPESCO. Nhiu sn phm ca Cng ty xut khu sang cc nc ng Nam , Trung quc, i loan. S khch hng v doanh s ngoi thng tng lin tc t 15-17 triu USD/nm. VIPESCO cn l c quyn tiu th sn phm cho cc hng nc ngoi ni ting nh AVENTIS, CALTEX, GROWING, NIHON NOHYAKU S tin cy ln nhau v cng c li l phng chm ca VIPESCO trong quan h quc t, l yu t a n thnh cng v nng cao uy tn ca Cng ty. Trong giai on pht trin y ha hn sp ti VIPESCO sn sng n nhn mi s hp tc vi bt c i tc nc ngoi no.

II.

MT S CNG NGH SN XUT CA CNG TY


Cng ty ch yu l gia cng cc sn phm. Hin nay duy nht ch c dy chuyn

sn xut ng oxy clorua l hon chnh do cng ty sn xut. 1. Dy chuyn sn xut ng oxy clorua. a. Sn phm: 23

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

ng oxyclorua [ CuO.CaCl2.4H2O ],cn c tn l ng oxyclorua kim hoc ng II clorua oxit hyrat c s dng nh thuc tr nm bnh t nhng nm 1990 vi tn thng mi Cupravit (hang Bayer) hoc Recop (hng Sandoz). Tuy nhin do nhng tnh cht u vit nn n vn cn c s dng n ngy nay. Tnh cht ho l: ng oxyclorua l bt mu xanh da tri, khng tan trong nc v dung mi hu c, tan trong axt long to thnh mui ng II, tan trong NH4OH to thnh phc ion. Thnh phn ca hot cht ph thuc vo iu kin cng ngh sn xut. Hot cht c tnh n mn kim loi . Hot tnh sinh hc v ng dng: ng oxyclorua l thuc tr nm c tnh phng hn l tr. thuc c tc dng vi cc nm Phytophthora infecstans, Pseudoperonospora humuli trn rau qu nh c chua, khoai ty Vit Nam, ng oxyclorua c sn xut t nm 1980. Thuc gia cng dng WP, dng n hoc hn hp vi cc thuc tr nm khc nh Cacbendazim, Zineb. Dithan b. Dy chuyn cng ngh:
Nc + ng Sunpht +mui n Thng phn ng (Khuy trn + vi)

B lng

Phi kh

Trn vi nh du

My vy ly tm

Nghin nh

ng gi

24

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
Hnh 4: Dy chuyn sn xut ng oxyclorua c. Thuyt minh dy chuyn cng ngh:

2009

Nguyn liu ban u l CuSO498%, NaCl, H2O, CaCO3 c chun b sn lng theo tng m sn phm. u tin cho khong 450ml nc vo thit b phn ng trc sau cho dn dn 450kg ng sunpht v 54kg mui n vo, bt cnh khuy trn u. Sau khi trn trong khong 2- 3 ting th t t cho 260kg bt CaCO 3 vo thc hin phn ng. Lc ny nu cho bt CaCO 3 vo mt lc th phn ng xy ra mnh lit c th lm tro ra khi b. PTP: CuSO4 + 2NaCl + CaCO3 +4 H2O CuO.CaCl2.4H2O + Na2SO4 + CO2

Thi gian phn ng cho mi m khong 8h. Sau phn ng sn phm c tho xung b lng, loi bt nc, sau tip tc cho vo my vy li tm loi b ht nc trong sn phm. Sau khi lc b ht nc, sn phm c trn vi SanimanH to nh du trong my trn. Qu trnh trn nh du ny c mc ch lm tng bm dnh trn cy trng v kt thc khi to c mt hn hp c qunh ri c ri ra phi kh n khi t tiu chun th c nghin v ch ng gi, lu kho. ii. Dy chuyn gia cng cc sn phm thuc dng dung dch hoc thuc dng bt: a. S cng ngh:

25

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Nguyn liu

B phi liu

Thng cha

Dn nhn v ng thng

ng chai ( ng gi)

Thng cha khu ng gi

Hnh 5: S dy chuyn sn xut gia cng thuc nc b.Thuyt minh : Nguyn liu ban u l cc thuc c mua v cho qu trnh gia cng, cc thuc ny c trn theo t l nht nh theo cng ngh ca cng ty. Tt c c a vo bn phi liu, bt cnh khuy trn u cc nguyn liu. Nguyn liu l dng dung dch c bm vo thit b phn ng, bt cnh khuy trn u nguyn liu, sau khuy trn ly mu ra mang i kim tra nu t yu cu th c chuyn sang giai on tip theo l bm ln bn cha. T y, dng thuc c a v cc dy chuyn ng gi theo ng dn, n cc thng nh hn mi dy chuyn. Chai c a vo my ng chai, nh bm ht chn khng to s chnh lch p sut dung dch s c bm vo chai. Qu trnh a thuc vo chai nh mt ng dn nh liu, tuy nhin mi liu thuc a vo cha u nn c 1 cng nhn s kim tra cc chai thuc ny. Nu y qu hoc t qu s c ht ra hoc b sung thm thuc.

26

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

My ng chai c h thng ht kh c a ra ngoi x l. Chai c a qua bng ti n v tr dn nhn v ng np. Trn h thng bng truyn cng c h thng ht kh c. i vi sn phm ng gi, dung dch hoc bt c pha trn s cho vo cc phu ca my ng gi. My lm vic theo chu k, dung dch c nh lng theo chu k ca pittong v c iu chnh bng c. dung dch hoc bt s theo phu chy xung ti, sau cc ti ny s c dn kn bng nhit, chuyn sang ng bao v thng. Cc sn phm gia cng ca cng ty: Thuc tr c dng dung dch Thuc tr su: o Andoril 50EC vi hot cht cypermethrin 50g/l o Antaphos 50 EC vi hot cht l alpha-cymerthrin 50g/l Thuc tr nm: o Vidoc 30BTN vi hot cht chnh l ng oxyclorua o Vizines80BTN vi cc thnh phn: Zineb, sunfua, ph gia. iii. H thng x l kh thi a. S h thng:

27

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

qut ht
1

qut ht

Hnh 6: S h thng x l kh thi b. Thuyt minh : Kh thi t cc b phn sn xut theo ng dn nh qut ht i vo h thng x l kh. H thng x l gm 1 bung lm sch kh c 3 lp, trong lp c nha di cng, gia l mt lp c v than hot tnh, trn cng l mt lp than hot tnh, 1 bm dung dch, 1 b cha ho cht x l v h thng ng dn dung dch v kh thi. H thng vn hnh, van s 3 dn NaOH v KMnO4 t ngoi vo c ng li, van s 1 m ra. Bm chy ht dung dch ho cht t b ti vo cc lp c nha. Kh i t di ln, gp dung dch t trn xung s b oxi ho, lm sch chy xung di bung v theo h thng ng dn tr v b. Khi nng dung dch trong b cha khng lm sch kh th van s 1 ng li, van s 3 m ra, dung dch t b c ht ra ngoi thay dch mi. 28

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Trong qu trnh sn xut cng nhn vn hnh lun lun theo di hot ng ca h thng, nu c ting n l qut ht hoc trong h thng th dng my v bo co cho cn b qun l khc phc. Khng c cc vt dng nh gi lau, qun o, cc vt nh trc ca ming ng ht, nh vy s lm tc ng ng v hng qut kh. Khi dng hot ng ngt in cc qut ht 1 v 2, bm ht dung dch v cu dao tng. Tu theo mc sn xut, hng ngy kim tra pH ca dung dch. Thc hin ch bo dng, ra sch c nha v hot ha li than hot tnh 3thng/ 1ln.

29

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

PHN IV: CNG TY C PHN DC PHM MEDIPLANTEX


I. GII THIU V CNG TY
Cng ty c phn Dc TW - MEDIPLANTEX tin thn l cng ty Dc liu Trung ng I, c c phn ha theo quyt nh s 4410/QBYT ngy 07/12/2004 ca B Y t. Cng ty c php sn xut kinh doanh, xut nhp khu cc mt hng tn dc, ng dc, nguyn liu ho dc, dng c y t, m phm, bao b, ph liu cao cp cho ngnh dc m phm, sn phm dinh dng v cc mt hng khc. 1. Nng lc nhn s v k thut: Hin nay, cng ty c trn 400 cn b cng nhn vin trong c trn 140 cn b c trnh i hc v sau i hc. S cn li l cn b trung cp k thut vin, cng nhn c tay ngh cao.Cng ty c X nghip sn xut thuc vin t tiu chun GMPASEAN t nm 2000, phng kim nghim t tiu chun GLP -ASEAN, kho thuc t tiu chun GSP ASEAN v n thng 6/2007 Cng ty i vo vn hnh nh my sn xut thuc t tiu chun GMP-WHO ti M linh Vnh Phc ngoi ra cn c xng chit xut cc nguyn liu, bn tng hp cc nguyn liu lm thuc t dc liu trong nc vi trang thit b my mc hin i. Cng ty c Cc qun l dc cho php lu hnh trn 150 sn phm c cht lng cao, ph hp vi nhu cu iu tr, tt c cc sn phm sn xut u c kim tra cht lng trn h thng thit b hin i. Nguyn liu sn xut ho dc ch yu nhp khu t cc nh cung cp, cc cng ty a quc gia c uy tn, cc sn phm c sn xut t dc tho u tiu chun ho cao, t cc tiu chun dc in Vit Nam v Quc t.

30

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
ii. Nng lc kinh doanh

2009

Kinh doanh nhp khu: Trong nhng nm qua, mc d c s cnh tranh gay gt gia cc doanh nghip vi nhau, nhng ton th cn b cng nhn vin ca Cng ty CP Dc Trung ng Mediplantex c rt nhiu c gng trong vic duy tr bn hng c v tm kim bn hng mi. Hin nay, cng ty thit lp c mi quan h vi cc Cng ty trn 20 nc t chu u ti chu nh: Php, Anh, o, c, Tip, Trung Quc, n .. . Kim nghch nhp khu ca cng ty trong cc nm gn y t khong 16.000 000 USD mi nm trn 6 th trng trng im: Php, c, c, n , Nht, Hn Quc. Sn phm thuc nhp khu c s Visa ca Cc qun l dc vi s lng trn 200 loi thuc khc nhau vi cc nhm c th nh: nhm thuc khng sinh, h st, ng rut, tim mch, thn kinh, b dng. Kinh doanh trong nc:Cng ty CP Dc TW Mediplantex tham gia cung cp thuc cho nhiu chng trnh thuc ca nh nc v ca B Y t cng nh cung cp thuc cho cc bnh vin ln nh Bch Mai, Vit c, Vin 108, Vin 103, Hu ngh, Vin 198, Vin Nhi Thu in, Vin Da liu..... v hu ht cc tnh, thnh trn c nc. Chnh t s n lc ca Ban lnh o cng ty cng s on kt ca tp th cn b cng nhn vin cng vi s ng h ca ng o bn hng m tng doanh s hng nm t trn 500 t ng Vit Nam, thu np thu vo ngn sch nh nc mi nm khong 15 t ng Vit Nam. V chng ti ngh rng doanh s khng phi l iu m chng ti mong mi, iu m chng ti hng ti l mi ngi c nhu cu thuc u c s dng thuc hp l, an ton v hiu qu. 31

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Cng ty c cc chi nhnh khu vc : Chi nhnh TPHCM phc v thnh ph HCM v cc tnh ng bng nam b, Chi nhnh c Lc phc v cc tnh min trung, Ty nguyn v ng nam b, Ngoi ra cn c cc Chi nhnh Bc Giang, Chi nhnh Thi Bnh, Chi nhnh ti nc Lo. Kinh doanh xut khu:Cng ty CP Dc TW- Mediplantex khng ch sn xut , kinh doanh phc v th trng trong nc m cn xut khu sang nhiu nc trn th gii nh : Nga, Lo, Campuchia, cc nc Chu u, Myanma , Nht Bn, n Cc sn phm xut khu ch yu l nguyn liu, thnh phm thuc cha st rt c chit xut t Thanh Hao Hoa Vng, cc loi thnh phn tn dc, ng dc, tinh du. iii. Nhng thnh tu ni bt gn y Vi nhng thnh tch t c, Cng ty CP dc TW Mediplantex c nh nc v Chnh ph tng thng:
Gii thng Hun chng lao ng hng Ba Hun chng lao ng hng Hai Hun chng lao ng hng Hai Bng khen ca Th tng chnh ph Gii thng H ch Minh Chng nhn thng hiu uy tn Chng nhn thng hiu mnh Nm t 1980 1985 2001 2001 2003 2004 2004

32

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Thng hiu ni ting Sao vng t Vit Cp vng pht trin bn vng Cp vng Uy tn thng mi quc t v qun l thng hiu ton cu

2005 2005 2006 2007

Nhiu bng khen ca B Y t, Tng cng ty dc Vit Nam, UBNDTP H Ni v thnh tch sn xut, kinh doanh, xut khu v nhiu huy chng v bng khen v cht lng sn phm ti cc hi ch trong nc v quc t. H thng phn phi ca Cng ty bao trm trn lnh th khng nhng trong nc m c mt s nc bn p ng mi nhu cu ca ngi tiu dng vi thc trch nhim cao v phng chm "V sc kho v v p con ngi''. Vi nhng c gng v nhng thnh tu t c, Mediplantex lun l im n ca cc khch hng trong v ngoi nc. iv. Phm vi hot ng Theo giy ng k kinh doanh s 0103007436 do S k honh v u t H Ni cp ngy 14 thng 4 nm 2005, ng k thay i ln 3 ngy 18/10/2007 Cng ty CP dc TW Mediplantex c php kinh doanh v sn xut trong cc lnh vc sau: Kinh doanh dc phm. Kinh doanh m phm, sn phm v sinh v thc phm dng sinh; lng thc, thc phm.

33

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Kinh doanh nguyn liu lm thuc, dc liu, tinh du, hng liu, ph liu, ha cht (tr ha cht nh nc cm), cht mu phc v cho dc phm, m phm, thc phm v cng ngh. Xut nhp khu cc mt hng Cng ty kinh doanh. Mua bn my mc, thit b y t; my mc, thit b bao b phc v cho: sn xut tn dc, thuc y hc c truyn, m phm, thc phm b dng. Trng cy dc liu. Kinh doanh bt ng sn.Cho thu nh ca, vn phng, kho tng. Dch v mi gii u t, mi gii thng mi v y thc xut nhp khu. Kinh doanh vacxin sinh phm y t; Sn xut, mua bn gia dng, cc mt hng in t, in lnh, in thoi v thit b linh kin in t, in lnh, din thoi; i l mua, i l bn, k gi hng ha; Phng chn tr y hc c truyn.

34

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
v. C cu t chc
i hi c ng

2009

Hi ng qun tr

Ban kim sot

Tng gim c Ph tng gim c Phng kim tra cht lng Cc ca hng P. Ti chnh K ton Cc vn phng i din ti nc ngoi P. Th trng Marketinh Cc nh phn phi Phng Xut khu P. KH sn xut v nhp khu P. m bo cht lng Phng kinh doanh dc liu

Phng t chc hnh chnh

Kho vn Ch nhnh Bc Ninh

P. Nghin cu v pht trin

Chi nhnh c Lc

XN SX Thuc s 1

Chi nhnh Thi Bnh

Xng Ha Dc

Chi nhnh H Ch MInh

Hnh 7: C cu t chc cng ty c phn dc phm Trung ng Mediplantex

Nh my Dc phm s 2

II.

PHN XUNG SN XUT


Cng ty hin ang sn xut cc loi thuc vin, do cc phn xng sn xut

cng nh hng sn xut thuc vin vi tiu ch l t tiu chun GMP WHO. 35

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Trc y phn xng ny l 2 xng nh: xng sn xut thuc vin v xng sn xut ng dc. 1. Yu cu v GMP t c tiu chun GMP (hin nay l GMP WHO) th c rt nhiu yu cu nhng c bn nht l nhng yu t sau: Yu t con ngi: c o to ng theo ngh nghip, c nng lc, nhit tnh v quyt tm (yu t con ngi l yu t quan trng nht). Yu t trang thit b nh xng: C mt s yu cu c th nh din tch mt bng, b mt nh xng (tng, trn, sn nh...), cng nh sng, n ti a cho php, mc pht thi bi ca thit b Yu t mi trng: Mi trng u vo: i vi tu tng loi mt hng, chng loi thuc, tng giai on s c nhng yu cu khc nhau. V d i vi phn xng ny th mc cp lc khng kh cui cng trc khi vo trong xng l mng lc Hepa H-13 tc l cc ht bi c kch thc ln hn 5 m l nh hn 100.000 ht/m3. Mc thng kh (trao i khng kh vi mi trng bn ngoi) thng thng c quy nh phi ln hn 20 ln/gi. Mc nhim khng kh sau khi ra khi xng cng c quy nh ring khng gy nhim mi trng. Yu t v h s quy trnh: Tt c cc quy trnh lm vic u c ghi chp li y . u tin l vit ra nhng ci g mnh nh s lm, sau lm theo nhng g vit, cui cng ghi chp li nhng g lm.

36

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

ii. C cu t chc v dy chuyn sn xut ca xng GMP Trc khi c vo cc phng sn xut, cng nhn phi i qua phng thay qun o, phng kh trng. Cc phng ny c cch bit nhau bi cc ca hot ng theo nguyn tc ch m c mt ca, tc l khi ca ny ang m th khng th m c cnh ca kia. Nguyn nhn ca vic ny l cc loi cn trng khng vo c khu vc sn xut v lm sch mi bi bn trn ngi trc khi vo lm vic. Dy chuyn sn xut trong xng GMP c chia 5 t l : T phc v : Ph trch c, in, hi t, v sinh cng nghip .... T pha ch : Nhim v chnh l cn ong nguyn liu v pha ch chng li theo quy trnh ca tng loi sn phm. T ny c lit vo khu vc kn v c kim sot cht ch theo cc iu kin tiu chun GMP. Nguyn liu c mua v a vo phng giao nhn nguyn liu theo mt ng i ring, c x l v chun b cho pha ch to cm trc khi dp vin. Cc nguyn liu nu c kim tra t tiu chun s c dn nhn xanh ri chuyn vo cc thng vo ni tp trung nguyn liu cho sn xut. Nguyn liu tn ti nhiu dng: dng bt, dng ht c a vo my xay (B03). Ch cc my xay khng c ch to bng Fe trnh cho nguyn liu phn ng khi tip xc vi Fe. Vi cc nguyn liu dng ht cng vi s lng nhiu th chuyn vo my c h thng bnh rng v trc quay li tm xay ht, ht sau chui ry thch hp thnh ht ph hp mc ch yu cu. 37 xay

qua cc l

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

Vi cc nguyn liu t, ht khng cng qu, chuyn vo my xay ca Trung Quc xay theo nguyn tc chem. ht to dng bt mn. Cc t dc trn cng c x l bng my rung ht t dc ri xung cc l ry. T dc gm cc loi nh bt Talc, magiestearat, bt sn Nguyn liu v t dc sau khi x l nh trn s c chuyn qua phng cn (B07). y c 2 cn in t, mt cn l cn s lng ln, mt cn cn s lng nh cn chia nguyn liu cho tng m. Cc cn phi tuyt i sch, trnh bi v m. Sau khi cn chia l, chia m nguyn liu c a vo phng B09 ch pha ch cho cc cng on tip theo. Tip theo cc nguyn liu c chuyn sang phng pha ch. u tin dc cht, t dc v cht kt dnh c trn vi nhau trong my nho cao tc ( C02) to thnh mt hn hp t. Cht kt dnh y cng l mt loi t dc c nu ti ni nu to thnh mt loi h dnh. My nho cao tc c 1 cnh qut quay trn v 1 trc ph lm o u khi nguyn liu. Ban u nguyn liu c trn kh, khi cho h vo s khng o u c khi bt v vy trc ph c nhim v lm u hn hp ny. Cng sut ca my l 80kg/m. Vi cc loi thuc vin nhng (vin nang) th dc cht v t dc khng cn phi trn thnh hn hp t nn c trn trong my trn bt kp: cm v t dc c a vo my trn hnh lp phng v theo nguyn tc lp mt (dc cht -> t dc -> dc cht). Hn hp khng c trn qu lu. Sau khi to hn hp t t yu cu, hn hp c em i sy kh bng my sy tng si t m 1- 3% v t kch thc ht cm theo yu cu ri li

38

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

c trn u trong my trn l ng nht ng nht trong c l. Cng sut ca my trn l ng nht l 300kg/m. Trc khi c ng thnh vin, cm c a vo phng bit tr cm v a mu qua phng kim tra cht lng kim tra cc ch tiu. Nu t cc ch tiu theo yu cu cm c em i ng nang hoc dp vin, nu khng t yu cu th phi em i pha ch li. T dp vin : Nhim v l ng vin cho thuc bao, gm c thuc vin dp thng ln vin nang. T ny cng thuc khu vc cn c kim sot cht ch theo cc tiu chun GMP nhng c phn bt nghim ngt hn. cng on ny, vi cc loi thuc vin th cm c dp vin bng 2 my dp vin siu tc vi mt vng quay cho 200 vin thuc. i vi cc loi thuc nang th cm c ng vo nang bng 2 my ng nang. Vi cc thuc vin, sau khi c dp vin cn c mt cng on khng th thiu l bao phim cho vin. Mc ch ca vic bao phim l che giu mi v tht ca dc cht hoc to mt lp v bo v vin thuc v iu khin s tan ca thuc trong d dy hay trong rut. T ng v: Nhim v ca t ny l ng v cho cc vin thuc sau khi c dp vin hoc c bc nang. Lc ny vin thuc tip xc trc tip vi bao b nn cn c gi l ng gi cp 1 T ng gi thnh phm : Nhim v ca t ny l ng gi cp 2 v cp3. Cc v sau khi c dp s c ng gi thnh tng hp (ng gi cp 2) ri thnh tng thng (ng gi cp 3) thun tin cho vic lu kho, vn chuyn n tn tay ngi tiu dng. 39

Nguyn Th L Na

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Bo co thc tp tt nghip III. KIM TRA CHT LNG

2009

Phng kim tra cht lng ca nh my c xy dng theo tiu chun GLP ASEAN c nhim v kim tra cht lng ca nguyn liu trc khi a vo sn xut, kim tra thnh phm xem c t yu cu hay khng trc khi em ra lu hnh trn th trng, ng thi cn kim tra v nh gi cht lng thuc a ra cch s dng cng nh khuyn co cho ngi s dng. Trong phng kim tra cht lng c cc phng ban nh, mi phng li c mt nhim v khc nhau. u tin l phng ghi chp h s (H01): Cc mu trc khi a i kim tra u phi c ng k ti y v c phn vo cc phng kim tra trc tip. Tip theo l phng TLC (H03): y l phng sc k bn mng dng kim tra dc liu trong ng y. Cc dc liu c nghin nh ri ngm vo dung mi cc hot cht tch ra khi dc liu vo dung mi, sau dng sc k bn mng kim tra nh tnh cc hot cht ny bng cch so snh vi cht mu chun. kim tra cht lng dc liu cn dng n cc ch tiu khc nh vi phu, soi bt bn cnh cch kim tra nh tnh nh trn. c th kim tra mt cch hon ton th mu kim tra phi c kim tra ti cc phng phn tch ho l, phng phn tch ho hc, phng kim nghim vi sinh. Phng phn tch ho l (H05, H07) c nhim v o, kim tra cc tiu chun ho l ca nguyn liu hay thnh phm nh ho tan, r, mi mn c th kim tra c tt c cc ch tiu cn thit th phi c cc loi my o, phn tch. Do trong phng ny c cc loi my nh: My chun in th, My th ho tan, My o im chy, My th r, My ly tm (thay cho phng php lc), My sc k lng 40

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip

2009

hiu nng cao, My quang ph t ngoi, My chun Karl Fischer ( dng xc nh hm lng nc trong mu), Knh hin vi, My th mi mn ca vin nn, My phn cc k, n t ngoi, My o nht. Bn cnh phng phn tch ho l l phng phn tch ho hc (H09), c nhim v nh tnh, th tnh cht, th s tng tc ca thuc i vi cc hot cht khc. Quy trnh phn tch trong phng phn tch ho hc l: Cn mu Pha ch mu o bng cc dng c o hay th vi cc thuc th xc nh. Cui cng l phng kim nghim vi sinh ( H12): thuc sau khi t tiu chun cc khu phn tch ho l, phn tch ho hc c a vo phng ny kim tra nhim khun ca sn phm hay xc nh hot lc khng sinh ca thuc khng sinh. Bn cnh cc phng kim tra chnh nh trn th cn c cc phng khc nh: Phng cha cht i chiu ( H08), Phng cn (H10), Phng thit b gia nhit (H11), Phng ra dng c (H14), Phng lu mu (H02), Kho ho cht (H13).

IV.

CC H THNG PH TR.
1.X l nc: Vi sn xut thuc th yu cu v cht lng ngun nc lun c t ln hng

u v vy cng ty c c mt h thng x l nc.


Lc th Lm mm Lm mm Kh mi

Trao i ion

Thm thu ngc

Lc tinh

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Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
Hnh 8 : S h thng x l nc

2009

u tin ngun nc ging khoan c bm vo b c lc th ri lm mm 2 ln, sau nc c dn qua mt h thng kh mi ri c lc tinh loi b tt c cc ht phn tn trong nc. c th loi b hon ton cc tp cht c trong nc, nc phi c dn qua mt ct thm thu ngc v cui cng l qua ct trao i ion. Lc ny nc sch hon ton v c th a vo sn xut v sinh hot. 2.iu ha khng kh: Vi xng t chun GMP WHO th yu cu v khng kh trong xng rt nghim ngt. Do phi c mt h thng cp kh vo cc phng sn xut t c cc yu cu ra. H thng ny khng ch c nhim v cung cp khng kh m cn c nhim v iu ha nhit , to chnh lch p sut gia cc b phn, iu chnh m v lc kh trc khi a vo cng nh x l kh thi trc khi thi ra mi trng. 3.X l nc thi: Nc thi do hot ng sn xut thi ra cha rt nhiu cht thi gy nhim mi trng. V vy trc khi x ra mi trng cng cn phi c x l trnh nhim
Sc vi khun Ct mch cc hp cht hu c bng Ozn Lng bn

a ra mi trng

Lc th

. 42

Nguyn Th L Na

Ha Dc & HCBVTV_ K49

Bo co thc tp tt nghip
Hnh 9: S x l nc thi.

2009

Nc thi c dn qua cc ng dn vo b cha. Ti y u tin ngi ta sc vi khun vo b vi khun phn hy mt s cc cht hu c trong nc. Sau nc thi c a sang mt b khc v c sc kh Ozon ct mch cc cht hu c mch di ri c dn vo mt b lng bn lng bn thi. Lc ny phn nc thi tng i sch v c lc th loi ht bn trc khi a ra mi trng.

V.

CC SN PHM CA CNG TY.


1. Cc thuc st rt : Artesunate, Amodianate 2. Thuc tc dng ti h h hp: Comazil, Doxmin, Esha, Paracetamol, Ho b ph, Terpin codein.

2.

Thuc tc dng ti h thn kinh, ni tit, corticoid: Glyabed, Bangren,

Medidangen, Alphachymotrypsin, Prednisolon, Dexamthason, Meditriam, Diclofenac, Gim au thn kinh s 2, Epfepara codein, Rudexen, Gim au thn kinh, Tuzamin, Lusanti. 3. Thuc khng sinh: Acyclovir, Artesumate, Rotaforte, Roxi thromycin,

Medicipro, Mediclion, Lincomycin, Doxycyclin, Cotrimoxazol, Receptol 480, tetracycline, Cloromycetin, Neazi, Clatab, Clinecid. 4. Thuc dng cho h tiu ha, gan mt:Melankit, Silymax, Omeprazol, Antesik,

Antipylo 5. Thuc h tim mch v to mu: Dumazil, A9 Cerebrazel, Medisamin, Vinpocetin,

ATP, Uniferon B9, Stustu, Levical, Piracetam, Superkan-F, Superkan.

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Bo co thc tp tt nghip
5.

2009

Vitamin v khong cht: Mediphylamin, Mediroten, Biotin, Bequantene,

Amivital-F, Vitamin B1+B6+B12, Vitamin C, Siro Mediphylamin, Bentanzyme, Magnesi- B6, Glucose, Potardin 10%. 6. Thuc h tit niu sinh dc ngoi da: Nystatin, Deginal, Antipylo, Melankit,

Antesik, Omeprazol, Silymax. 7. Ru b - Ch thuc: Cn long ng tu, Forsek, Ru b Hi Linh, Severnus,

Ch Vng, Tr gng.

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Bo co thc tp tt nghip

2009

KT LUN
Trong t thc tp tt nghip va qua em c trc tip quan st mt s qu trnh sn xut thuc. Qua em thy rng sn xut c ra mt sn phm thuc phi tri qua rt nhiu cng on v i hi rt nhiu yu cu kht khe. Tuy nhin vic sn xut thuc nc ta a s ch l bo ch (nhp nguyn liu t nc ngoi, sau trn thm cc t dc cn thit). Do Nh nc vn v ang u t vo pht trin ngnh ny v hin nay bc u c cc cng ty vi dy chuyn sn xut GMP t WHO. Qua t thc tp ny, em tm hiu c phn no mi lin h gia l thuyt hc v thc t sn xut, cch t chc cng nh vn hnh ca cc dy chuyn sn xut. Tuy nhin do thi gian thc tp ngn v c nhiu yu t khch quan nn bo co ca em chc chn cn nhiu sai st, knh mong cc thy c gip bo co ca em c hon thin hn. Em xin chn thnh cm n thy Nguyn Tun Anh, cc c ch cc cng ty tn tnh ch bo, gip cho em thm nhng kinh nghim thc t v cng qu gi. Sinh vin : Nguyn Th L Na

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