BIO 325 Quiz V Mohanty 1) Channels between chromosome territories in the interphase nucleus are called A. B. C. D. E.

Extrachromosomal elements Localized zones Nonlocalized zones Interchromosomal domain Subchromosomal territories 2) What is the name of the protein that functions as cell cycle regulator and causes physiological cell death when DNA damage is irreparable? A. B. C. D. E. P21 P34 cyclin p53 phosphokinase 3) The retinoblastoma protein serves as a(n)............in regulating the cell cycle. A) B) C) D) E) tumor suppressor tumor enhancer regulator oncogene protooncogene 4) ........................ is an important feature of homeobox containing transcription factors. A. Zincfinger B. Basic leucinzipper motif C. Helixturnhelix motif D. Transactivating domain E. None of the above 5) Sex determination in Drosophila is a model for regulation of A. B. C. D. E. Histone modification Transcriptional regulation Alternative splicing 5'capping regulation Protein folding and modifications 6) Name the protein that combines with cyclins to exert local control of the cell cycle. A) B) C) D) E) cyclindependent kinase phosphatase ATPase Integrase Hexokinase 7) Two modular elements that appear as consensus sequences upstream from the transcription start site in eukaryotes are A) B) C) D) E) microsatellites and transposons rDNA and nucleolar organizers TATA and CAAT TTCA and CCTT Enhancers and telomeres 8) Protooncogenes A. B. C. D. Are important for normal cell growth and differentiation If mutated or aberrantly expressed can contribute to development of cancer Encode transcription factors, signal transduction molecules and cellcycle regulators All of the above E. A and B 9) DNA methylation in refer eukaryotes to A) B) C) D) E) altering RNA polymerase activity by methylation changes in DNADNA hydrogen binding altering translational activity of highlymethylated tRNAs addition of methyl groups to adenine residues addition of methyl groups to the cytosine of CG doublets 10) Most eukaryotic regulation of gene expression occurs at the level of A. B. C. D. E. transcription. splicing and processing. transport of mRNA from the nucleus. mRNA degradation. translation. 11) The transcription of a gene can be enhanced by A. B. C. D. E. condensing of the chromatin. acetylating histones. the removal of transcription factors. methylation of DNA. All of the above. 12) A single gene may produce two or more different RNAs by the process of A. B. C. D. E. DNA methylation. histone acetylation. RNA interference. signal transduction. alternative splicing. 13) In chronic myelogenous leukemia (CML), a reciprocal translocation involving chromosome 9 and 22 results in the aberrant Philadelphia chromosome. A) True B) False 14) ras and cycline D1 are the two main tumorsuppressor genes . A) True B) False 15) The gene p53 is called guardian of the genome because it corrects mutations in the spindle apparatus before nondisjunction can occur A) True B) False

BIO 325 Quiz V Mohanty 16) Random fluctuation in allele frequency by chance is known as genetic drift. A) True B) False 17) Unregulated cell growth and metastasis are two fundamental properties of cancer cells. A) True B) False 18) All the checkpoints in cell cycle are either in the S or G1 phase. A) True B) False 19) Chromatin remodeling can occur in two different ways; changes in the nucleosomes and modifications of the DNA. A) True B) False 20) Heavily methylated DNA is associated with active transcription in vertebrates. A) True B) False

1) D 2) D 3) A 4) C 5) C 6) A 7) C 8) D 9) E 10) A 11) B 12) E 13) A 14) B 15) B 16) A 17) A 18) B 19) A 20) B