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OBJECTIVES
Understand syncope
Know Know
Syncope
Neurally-mediated reflex
syndromes
Self-limited loss of consciousness and postural tone Relatively rapid onset Variable warning symptoms Spontaneous, complete, and usually prompt recovery without medical or surgical intervention
Section I
NeurallyMediated
Orthostatic
Cardiac Arrhythmia
Structural CardioPulmonary
4
Acute Myocardial Ischemia Aortic Stenosis
1
Vasovagal syncope (VVS) Carotid sinus syndrome (CSS) Situational
Cough PostMicturition
2
Drug-Induced Autonomic
3
Brady
Sinus Node Dysfunction Atro Ventricular Block
Tachy
Vent Tacycardia VT Sinus VT (SVT)
Long QT Syndrome
Section II:
Diagnosis
Diagnostic Objectives
Distinguish true syncope from syncope mimics Determine presence of heart disease Establish the cause of syncope with sufficient
Assessment of prognosis
Initial Examination Detailed patient history Physical exam ECG Supine and upright
blood pressure
Monitoring Holter Event Insertable Loop Recorder (ILR) Cardiac Imaging Special Investigations Head-up tilt test Hemodynamics Electrophysiology study
Syncope
Certain Diagnosis Suspected Diagnosis Unexplained Syncope
Not Syncope
Cardiac Likely
Single/Rare Episodes
Cardiac Tests
No Further Evaluation
Re-Appraisal
Re-Appraisal
Treatment
Treatment
Treatment
Treatment
Vital signs
Heart rate
Method1
Absolute contraindications2
Dont occlude
Supine and upright posture
(on tilt table)
Complications
Outcome
Primarily neurological
60 - 80
Ambulatory ECG
Holter monitoring
Event recorder
OPTION
12-Lead 10 Seconds
2 Days
ILR 0 1 2 3 4 5 6 7 8 9 10 11 12 13
14
TIME (Months)
Protocols vary Useful as diagnostic adjunct in atypical syncope cases Useful in teaching patients to recognize prodromal symptoms Not useful in assessing treatment
60 - 80
cardiac arrhythmias
Patients who experience transient symptoms that may suggest a
cardiac arrhythmia
Section III:
Specific Conditions and Treatment
Specific Conditions
Cardiac
arrhythmia
Brady/Tachy
Long QT syndrome
Torsade de pointes Brugada
Drug-induced
Structural
cardio-pulmonary
Neurally-mediated
Cardiac Syncope
Tachy and brady arrhythmias Myocardial ischemia, aortic stenosis, pulmonary hypertension,
aortic dissection
Acute MI/Ischemia
Hypertrophic cardiomyopathy
Valvular abnormalities
Bradyarrhythmias
Tachyarrhythmias
Arrhythmia 22%
(13-32%)
Seidl K. Europace. 2000;2(3):256-262. Krahn AD. PACE. 2002;25:37-41. Medtronic ILR Replacement Data. FY03, 04. On file.
Long QT Syndromes
Mechanism
Prevalence
Schwartz P, Priori S. In: Zipes D and Jalife J, eds. Cardiac Electrophysiology. Saunders;2004:651-659.
Drug-Induced QT Prolongation
(List is continuously being updated)
Antiarrhythmics
Antibiotics
Class IA
Erythromycin, Pentamidine,
Fluconazole, Ciprofloxacin and its relatives
Class III
Antianginal
Agents
Nonsedating antihistamines
Psychoactive Agents
Terfenadine*, Astemizole
Others
Cisapride*, Droperidol,
Haloperidol
08:23:21
0.0 -0.2 -0.4 :21 :22 :23 :24 :25 :26 :27 :28 :29 0.4 0.2
8:23:29
0.0 -0.2 -0.4 :29 :30 :31 :32 :33 :34 :35 :36 :37 0.4 0.2
08:23:37
0.0 -0.2 -0.4 :37 :38 :39 :40 :41 :42 :43 :44 :45
Atrial tachyarrhythmias
AVRT due to accessory pathway Ablate pathway AVNRT Ablate AV nodal slow pathway Atrial fib Pacing, linear/focal ablation for paroxysmal AF
Ventricular tachyarrhythmias
Post-micturition Cough
Swallow
Defecation Blood drawing, etc.
VVS Diagnosis
Long-term prevention
Acute intervention
Physical maneuvers, eg, crossing legs or tugging arms Lowering head Lying down
Support hose
Drug therapy Pacing
Objectives
Reduce syncope
susceptibility/recurrences
Technique
CSS Etiology
Sensory nerve endings in the carotid sinus walls respond to deformation Deafferentation of neck muscles may contribute
Carotid Sinus
Orthostatic Hypotension
Diabetes
Diuretics Vasodilators
Alcohol Amyloid
Suspected/known significant heart disease ECG abnormalities suggesting potential life-threatening arrhythmic cause Syncope during exercise Severe injury or accident
Conclusion
Syncope is a common symptom with many causes Deserves thorough investigation and appropriate treatment A disciplined approach is essential
Brief Statement
Indications 9526 Reveal Plus Insertable Loop Recorder The Reveal Plus ILR is an implantable patient- and automatically activated monitoring system that records subcutaneous ECG and is indicated for Patients with clinical syndromes or situations at increased risk of cardiac arrhythmias Patients who experience transient symptoms that may suggest a cardiac arrhythmia
6191 Activator
The Model 6191 Activator is intended for use in combination with a Medtronic Model 9526 Reveal Plus Insertable Loop Recorder. Contraindications There are no known contraindications for the implantation of the Reveal Plus ILR. However, the patients particular medical condition may dictate whether or not a subcutaneous, chronically implanted device can be tolerated. Warnings/Precautions 9526 Reveal Plus Insertable Loop Recorder Patients with the Reveal Plus ILR should avoid sources of magnetic resonance imaging, diathermy, high sources of radiation, electrosurgical cautery, external defibrillation, lithotripsy, and radiofrequency ablation to avoid electrical reset of the device, and/or inappropriate sensing. 6191 Activator Operation of the Model 6191 Activator near sources of electromagnetic interference, such as cellular phones, computer monitors, etc., may adversely affect the performance of this device. Potential Complications Potential complications include, but are not limited to, body tissue rejection phenomena, including local tissue reaction, infection, device migration and erosion of the device through the skin. 2090 Programmer
The Medtronic/Vitatron CareLink programmer system is comprised of prescription devices indicated for use in the interrogation and programming of implantable medical devices. Prior to use, refer to the Programmer Reference Guide as well as the appropriate programmer software and implantable device technical manuals for more information related to specific implantable device models. Programming should be attempted only by appropriately trained personnel after careful study of the technical manual for the implantable device and after careful determination of appropriate parameter values based on the patient's condition and pacing system used. The Medtronic/Vitatron CareLink programmer must be used only for programming implantable devices manufactured by Medtronic or Vitatron.
See the device manual for detailed information regarding the implant procedure, indications, contraindications, warnings, precautions, and potential complications/adverse events. For further information, please call Medtronic at 1-800-328-2518 and/or consult Medtronics website at www.medtronic.com. To learn more about syncope, visit www.fainting.com. Caution: Federal law (USA) restricts this device to sale by or on the order of a physician.