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SYAHARA
HISTORY
Helicobacter pylori is a
Gram-negative bacterium that infects the lining of the stomach and duodenum.
Many cases of peptic ulcers, gastritis, and duodenitis are caused by H. pylori
infection.
However, many who are infected do not show any symptoms of disease.
Helicobacter spp. are the only known microorganisms that can thrive in the
highly acidic environment of the stomach.
Its helical shape (from which its name is derived) is thought to have evolved to
penetrate and colonize the mucus lining.[1]
Structure
H. pylori is a spiral-shaped gram-negative bacterium, about
3 micrometres long with a diameter of about 0.5 micrometre. It has 46
flagella. It is microaerophilic, i.e. it requires oxygen but at lower levels
than those contained in the atmosphere. It contains a hydrogenase which
can be used to obtain energy by oxidizing molecular hydrogen (H2) that is
With its flagella, the bacterium moves through the stomach lumen and drills
into the mucus gel layer of the stomach.
It then finds ways to live in various areas of the stomach.
- inside the mucus gel layer
- above epithelial cells
- and inside vacuoles in epithelial cells.
It produces large amounts of urease enzymes which are localized inside and
outside of the bacterium.
Urease metabolizes urea (which is normally secreted into the stomach) to
ammonia and carbon dioxide which neutralizes stomach acid.
The survival of H. pylori in the acidic stomach is dependant on urease and
eventually dies without it.
The ammonia that is produced is toxic to the epithelial cells, and with other
products of H. pylori, including protease, catalase, and phospholipases,
causes damage to those cells.
Mucus cells.
Treatment of infection
In peptic ulcer patients where infection is detected, the normal procedure is
eradicating H. pylori to allow the ulcer to heal.
Today the standard triple therapy is ( 7- 14 days ):
Triple therapies are used. Worldwide, accepted treatment regimens are
-BMT,
-LAC,
-OAC.
BMT regimen is based on the administration of bismuth subsalicylate,
metronidazole, and tetracycline. Add an H2-receptor antagonist for an additional 4
wk.
LAC regimen is based on the administration of lansoprazole, amoxicillin, and
clarithromycin.
OAC regimen is based on the administration of omeprazole, amoxicillin, and
clarithromycin.
Photograph of H. pylori
G raham patch