Professional Documents
Culture Documents
14 The CTL response to HIV infection is quite robust; however, these activated
CD8+ T cells have little
impact on viral clearance or inhibition of AIDS progression.
Which one of the following offers an explanation for this observation?
(A) HIV can directly infect CTL causing their lysis upon viral replication
(B) HIV infection of CTL results in insertion of viral DNA into areas of the host
genome critical for
cell function, thus, infected CTL are functionally impaired
(C) HIV peptides generated in infected cells do not fi t into the grooves of the host
cell class II MHC
molecules, thereby, inhibiting CTL recognition and killing
(D) HIV peptides have alterations which do notpermit efficient CTL TCR interactions
(E) HIV reverse transcriptase is highly efficient (not error prone) and thus protein
mutation is a rare
event