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DEFINITION
Genital herpes (GH) one
of the more common
sexually transmitted
disease caused by herpes
simplex virus
ETIOLOGY
EPIDEMIOLOGY
20 50 % ulcerative
lesion in patients.
80 - 100 % middle
age aged adults of
lower socio-economic
30 50 % adults
higer socio- economic
CLINICAL MANIFESTATIONS
DIAGNOSIS
DIFFERENTIAL DIAGNOSIS
Chancroid.
Lymphogranuloma
venerum.
Granuloma inguinale.
Gonorrhea.
Syphilis.
TREATMENT
Primary genital herpes :
Acyclovir :
Intravenous : 5 mg/kg q8h.
Oral : 400 mg PO 5 times/d.
Topical use : 5 % ointment
in polythylene glycol.
Valacyclovir : oral 500 mg po
bid for 5 days.
Immunotherapy :
Administration of HSV
vaccines with varying
adjuvant has been associated
with reduction in the
frequency of reactivation.
Prophylaxis of infection :
Barrier forms of
contraception, especially
condoms, may decrease
transmission of disease.
REGIMENS OF CDC
First episodes of GH :
Acyclovir 400 mg orally 3
times a day (7-10 days)
Acyclovir 200 mg orally 5
times a day (7-10 days)
Famciclovir 250 mg orally 3
times a day (7-10 days)
Valacyclovir 1 g orally twice
a day (7-10 days)
REGIMENS OF CDC
Recurrent episodes of GH :
Acyclovir 400 mg orally 3
times a day (5 days)
Acyclovir 200 mg orally 5
times a day (5 days)
Acyclovir 800 mg orally
twice a day (5 days)
REGIMENS OF CDC
-
REGIMENS OF CDC
REGIMENS OF CDC
Severe disease :
Acyclovir 5-10 mg/kg body
weight IV every 8 hours (2-7
days) or until clinical
improvement
Followed by oral antiviral
therapy to complete at least 10
days total therapy