Professional Documents
Culture Documents
KLINIK
Rahmatini
Bagian Farmakologi &
Terapi Fakultas Kedokteran
Universitas Andalas
DEFINISI
WHO ( 1988)
KONSEP
RESEPTOR
OBAT
EFEK
OBAT
KOMPLEK
O+R
KADAR OBAT
DALAM
PLASMA/SERUM
TUJUAN
FARMAKOLOGI KLINIK
F.Kinetika
F Dinamika
F Ekonomi
PHARMACOLOGICAL ASPECTS
IN CLINICAL PRACTICE
Pharmacokinetic
Pharmacodynamic
* Absorption / bioavailability
* Distribution
* Biotransformation
* Excretion
THERAPEUTIC DRUG
MONITORING (TDM)
Ph dynamic
Ph kinetic
Druginteraction
Measuring/
interpreting
plasma drug conc.
Therapeutic
response
Side effects
Toxic effects
40
30
Drug toxicity
20
Therapeutic level
10
m.e.c
Low therapy
1
Time (hour)
Drug formulation
Drug interaction
Environmental factors
Genetic variation
Renal and hepatic function
Digoxin toxicity
Congest.Heart Failure
Gentamycin toxicity
Gram () septicaemia
Renal damage
Pharmacokinetic parameters
Cmax (peak)
Half life
AUC 24
Time
Cmin
(trough)
Visualisation of half-life
Drug conc. (mg/l)
10
5
2.5
2
Hours
CONSIDERATION
Phkinetic
Phdynamic
Pheconomic
TUGAS
Alhamdulillah