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T 2 M1 K65
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(n v cps)
P=g/cm2
t= thi gian
k= hng s dng c
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FeCl3 +
mau xanh xm
nh
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1. Gii thiu
2. Phng php tin hanh
NI
DUNG
3. Kt qu va nh gi
4. Kt lun
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1. Gii thiu
Tretinoin ( retinoic acid) c s dng iu tr cc bnh vy nn, vy c,
mn trng c thng thng, u v cc bnh ngoi da khc, vi nhiu loi bo
ch khc nhau nh dung dch, sa, thuc m v cc loi kem.
Vi cc dng bo ch ny,
kh nng duy tr tc dng
km s dng cc t dc
to gel. Carpobol c s
dng v kh nng n nh
cao, tng thch v c tnh
thp.
Tng kh nng thm qua da s dng cc cht gy tng thm: mui
mt, cht din hot, glycol v dn xut
Kho st s nh hng ca mi trng hp th, nhit , pH, nng
thuc v cc tc ng ca cht tng cng thm thu ti s
khuch tn thuc trong cc loi gel carbopol tretinoin.
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Ni cung cp
Tretinoin
Carbopol 934
BF Goodrich (M)
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Ct
Pha ng
Detector
UV; = 348nm
Th tch tim
10 l
Tc dng
1ml/pht
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iu kin kho st
Nng DGME dao ng trong khong 0-50 ( v / v) %
nh hng ca nng thuc c gii phng t gel c
nghin cu theo cc nng 0.005 , 0.01 , 0.025 v 0.05% ( w /
w), vi nng DGME 40%
nh hng ca nhit trn tc gii phng thuc c thc
hin ti cc nhit 28 , 32, 37, 42 0C, vi nng DGME 40%
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3. Kt qu v nh gi
3.1. nh hng cua DGME n s giai phong cua thuc.
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3. Kt qu v nh gi
3.1. nh hng cua DGME n s giai phong cua thuc.
T th nghim cho thy, lng tch ly ca tretinoin khi gii
phng vi thi gian quan h tuyn tnh vi nhau
40% DGME
Kh nng gii
phng ca
tretinoin cao
>40%DGME
Kh nng
gii phng
tng khng
ng k.
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3. Kt qu v nh gi
3.2 Tac ng cua pH cua carbopol gel n s giai phong thuc.
Nghin cu s thay i
ca pH 5-8 thy kh nng
gii phng dc cht tng
khi pH ca carbopol gels
tng, c bit s trng n
va kt dnh ca carbopol
gels tng cao khi c
trung ha bi cc cht c
tnh
kim:
trimethanolamin.
KOH,
NaOH.
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3. Kt qu v nh gi
3.3 nh hng cua nng tretinoin ti s GP cua thuc.
.
Nng ca tretinoin i
vi s gii phng thuc
qua mng cellulose tng
hp c s dng 40%
DGME, 2% carbopol gel
vi nng : 0.005%;
0.01%; 0.025%; 0.05%
nng tretinoin cng
cao th kh nng gii phng
thuc cng cao.
3. Kt qu v nh gi
3.4 anh hng cua nhit n s giai phong thuc
Nhit tng th kh nng gii
phng thuc cng tng. Nhng
thng cc th nghim v tnh
thm ca thuc c tin hnh
nhit 37 C l nhit ca
da.
Nng lng hot ha (Ea) tnh
theo dc ca thi: ti nng
0,025% l 14,96 kcal/mol;
0,05% l 14,55 kcal/mol. Nh
vy s gii phng thuc t h
gel lin quan n nng lng.
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3. Kt qu v nh gi
3.5. Tinh thm cua tretinoin t dang gel khi cha cac cht
gy thm khac nhau qua da chut
Khi nghin cu kha nng thm
cua tretinoin qua da chut khi co
mt cht gy thm va khng: vi
cht gy thm: cac glycols, cht
din hoat khng ion hoa th kha
nng thm qua da tt hn. c
bit la polyoxyethylene 2-oleyl
ether.
Kha nng tng thm tng do lam
lng lp sng cua da va giam ti l
lipid.
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4. Kt lun
Qu trnh gii phng tretinoin t gel carbopol b nh hng
bi:
pH ca gel carbopol, gii phng tt nht pH 8.
nng thuc tng dn n s gii phng thuc t gel
tng, cho thy s ph thuc vo nng .
S tng ca nhit lm cho vic gii phng thuc tng
ln, ty thuc vo nng lng kch hot ca s thm thu.
Mt trong nhng cht tng thm c s dng nh glycol
v cc cht din hot khng ion ha , polyoxyethylene 2 oleyl ether cho hiu qu tng cng tt nht.
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