CC

CC DNG
DNG THUC
THUC RN
RN

THUC
THUC BT
BT

MC
MC TIU
TIU HC
HC TP
TP
1.

Trnh by c vai tr, v tr ca bt thuc trong

cc dng thuc rn.

2.

Trnh by c phn loi, u, nhc im, cc

t dc s dng trong thuc bt.

3.

Nu c cc c tnh ca bt thuc vn dng

trong KTBC v SDH cc dng thuc rn.

MC
MC TIU
TIU HC
HC TP
TP
4.

M t c qu trnh bo ch bt thuc qua 2

giai on: nghin v ry.

5.

Nu c k thut iu ch bt kp qua 2 giai

on: nghin bt n v trn bt kp.

6.

Phn tch c mt s cng thc thuc bt.

NH
NH NGHA
NGHA
Thuc bt l dng thuc rn, gm cc ht nh, kh
ti, c mn xc nh, c cha mt hay nhiu loi
dc cht. Ngoi dc cht, thuc bt cn c th thm
cc t dc nh t dc n, t dc ht, t dc
mu, t dc iu hng, v ...
Thuc bt c th dng ung, pha tim hay
dng ngoi.

Thuc
Thucbt
bt

Vin
Vinnn
nn

Bt
Btthuc
thuc

Ht
Ht

Vin
Vintrn
trn

Vin
Vinnang
nang
(cng)
(cng)

Bo ch
Gii phng

CLAMOXYL (SMITHKLINE BEECHAM)

CLAMOXYL (SMITHKLINE BEECHAM)

Bt pha siro 250 mg/5 ml:

Amoxicillin trihydrat

250 mg

T dc: crospovidon, aspartam, magnesi stearat, gm

xanthan, natri carboxy methyl cellulose, silic dioxyd keo
khan, natri benzoat, hng thm "chanh-o-du".

Mt s kiu ng gi thuc bt

Mt s c tnh ca tiu phn dc cht rn

vn dng trong bo ch
Kch thc tiu phn
Hnh dng tiu phn
Dng th hnh
Lc lin kt tiu phn
trn chy ca khi bt
xp ca tiu phn
xp ca khi bt
Khi lng ring
Kh nng chu nn

Cc phng php xc nh kch thc tiu phn

Tn x laser

Hnh dng tiu phn

Phng trnh Noyes - Whitney

dC D
S Cs C
dt
h

74 350 m
177 350 m

o lc kt dnh

o lc bm dnh

o tc trn chy ca bt

o tc trn chy ca bt

o tc trn chy ca bt

Mc trn chy

Gc ngh

Chy rt tt

25 30o

Chy tt

30 38o

Chy c

38 45o

Kt dnh

45 55o

Rt kt dnh

> 55o

nh gi kh nng trn chy v chu nn

Ch s nn Carr (Carrs compressibility index - CI):
CI =

Dg Dkhng g
Dg

Ch s Hausner (Hausner ratio):

HR =

Dg
Dkhng g

x 100

nh gi kh nng trn chy v chu nn

Mc trn
chy

CI

HR

< 10

1,00 1,11

Tt

11 15

1,12 1,18

Kh

16 20

1,19 1,25

Chy c

21 25

1,26 1,34

Km

26 - 31

1,35 1,45

Rt km

32 37

1,46 1,59

> 38

> 1,60

Rt tt

Rt, rt km

Thit b o th tch biu kin ca ht v bt

Xp k

X L TNH HUNG
Bt pha hn dch ampicilin khi dng cho bnh
nhn thy sinh kh dng thp v khng n nh.
Hy nu cc nguyn nhn c th gy ra hin
tng ny v bin php khc phc.

Ampicilin

My nghin bi

Thit b lm bt siu mn

Lactose phun sy

SuperTab 11SD

Foremost Lactose 316

Fast Flo

CC KIU THIT B NGHIN V P DNG

Kiu
nghin

Lc tc
ng

KTTP
(mesh)

p dng cho

Khng p
dng cho

20 80

Si, NL th c ngun
gc thc vt

NL b, d
v vn

20 200

Nghin mn nguyn
liu c x

NL mm

Hu ht cc NL

NL x

Ct

Ct ch

Hnh tinh

Va p &
nghin mi

Ba
Nghin bi

Va p

4 325

Trc ln

Nn p

20 200

NL mm

NL x

20 200

NL mm v si

NL x

NL d v vn v c
cng TB

NL mm
v dnh

Nghin mi Nghin mi
Fluid
energy

Va p &
nghin mi

C m

MT S LOI RY

MT S THIT B TRN

Thit b trn ch V

Cc bin php lm tng s ng u ca khi

bt khi trn bt kp?

Mt s kiu ng gi thuc bt

Thit b ng gi thuc bt

PAPS (Laboratoires M. RICHARD SA)

Lu hunh

8,5 g

Km undecylenat1,0 g
Bismuth gallat base 0,5 g
Menthol 0,5 g
Camphor 1,0 g
Acid salicylic 0,5 g
Km oxyd9,0 g
Acid boric 9,0 g
Tinh du hoa mi0,25 g
Talc

100,0 g

BT DNG NGOI
Triclosan 3,0 mg
Km undecylenat2,0 mg
Menthol 0,2 mg
Talc

926,8 mg

Magnesi stearat 30,0 mg

Tinh bt ng 30,0 mg
Cht thm

8,0 mg

ORACFAL (BRISTOL-MYERS SQUIBB)

Bt pha siro:
Cho 5 ml

Cho 1 l

Cefadroxil monohydrat
(tnh theo dng khan)

500 mg

6g

T dc: natri benzoat, Avicel, polysorbat 40,

saccarose, cht thm.

HPARGITOL (LERT)
Sorbitol

2,723 g

Acid citric 0,878 g

Arginin hydroclorid 0,500 g
Natri sulfat khan 0,066 g
Natri hydrophosphat

0,119 g

T dc: natri hydrocarbonat, saccarose, tinh du

cam, tinh du chanh.

BT PHA HN DCH AMOXICILIN V KALI

CLAVULANAT
Amoxicilin trihydrat
Kali clavulanat

1500,00 mg

393,60 mg

Gm xanthan 150,00 mg
Hydroxypropyl methylcellulose
Natri saccharin

1800,00 mg

150,00 mg

Silic dioxyd dng keo khan

300,00 mg

Acid succinic 10,00 mg

T dc hng o 183,60 mg
T dc hng du 236,40 mg
T dc hng chanh

731,14 mg

BT PHA HN DCH AZITHROMYCIN

Azithromycin dihydrat 1,263 g
Saccarose 23,169 g
Trinatri phosphat
Natri benzoat

0,108 g

0,090 g

Hydroxypropyl cellulose (Klucel EF) 0,015 g

Gm xanthan

0,015 g

T dc mi anh o 0,090 g
T dc mi vani 0,200 g
T dc mi chui 0,150 g

Rp.

Lu hunh kt ta 1,0 g
Km oxyd1,0 g
Magnesi carbonat
Bt talc

5,0 g

Du parafin 1,0 g
M.f.p

2,0 g

THUC BT AMOXICILIN
PHA HN DCH
Amoxicilin trihydrat

1,725 g ( 1,5g amoxicilin)

Natri benzoat

0,06 g

Natri saccarin

0,03 g

Gm xanthan

0,20 g

Riboflavin

0,05 g

Bt ng
Lactose
Vanilin

15,00 g
12,72 g

0,01 g

THUC BT PHA DUNG DCH

(TNH CHO 1 GI THUC)
Acid boric

4,350 g

Nhm - kali sulfat 0,600 g

Berberin 0,001 g
Mentol

0,012 g

Thymol 0,015 g
Phenol

0,005 g

THUC
THUC CM
CM

CC
GIAI
ON
BO
CH
THUC
CM

THUC CM ACECLOFENAC
Aceclofenac

50,00 mg

T dc mi cam 165,83 mg
Sorbitol 3292,30 mg
Lutrol F 68 169,23 mg
Cremophor RH 40 169,23 mg
Nc kh khong 2 ml

THUC CM ACETAMINOPHEN V
DIPHENHYDRAMIN HYDROCLORID
Acetaminophen (bt siu mn) 1650,00 mg
Diphenhydramin hydroclorid
250,00 mg
FD&C Yellow No. 10 Lake 0,90 mg
FD&C Red No. 40 0.0005 mg
Saccarose 18081,10 mg
Aspartam
200,00 mg
Tinh bt ng 250,00 mg
Acid citric
180,00 mg
Natri citrat
38,00 mg
Natri clorid 200,00 mg
T dc mi mt ong 240,00 mg
T dc mi chanh 100,00 mg
Nc tinh khit va

THUC CM SI BT ACETAMINOPHEN,
DOXYLAMIN V CAFEIN
Acetaminophen

500,00 mg

Doxylamin succinat
Cafein

5,00 mg

33,00 mg

Acid tartaric 391,00 mg

Natri hydrocarbonat

417,00 mg

Kollidon 30 6,00 mg
Isopropanol (hoc ethanol)
Natri citrat

30,00 mg

Saccarose 707,00 mg

va

THUC CM PHA HN DCH ERYTHROMYCIN

ETHYLSUCCINAT
Erythromycin ethylsuccinat 55,860 g
Saccarose 823,840 g
Natri citrat 95,095 g
Natri saccarin 1,128 g
FD&C Red No. 40 0,104 g
Natri carmellose (Sodium CMC 7 MFD)

0,543 g

Nh tng simethicon 30% (Simethicone M30) 8,151 g

Gm xanthan 4,932 g
T dc hng anh o
Nc tinh khit

2,382 g

15,200 g

THUC CM MULTIVITAMIN
Bt vitamin A+ D (50.000 IU/g) (BASF) 40,00 mg
Thiamin mononitrat (BASF)
5,00 mg
Riboflavin (BASF) 6,00 mg
Nicotinamid
22,00 mg
Pyridoxin hydroclorid (BASF) 4,50 mg
Calcium D-pantothenat (BASF)
30,00 mg
Cyanocobalamin (vi nang bao bi 0,1% gelatin)0,013 mg
Bt acid ascorbic (BASF) 230,00 mg
Bt vitamin E acetat 42,00 mg
Saccarose, nghin mn 4000,00 mg
Kollidon CL-M 1000,00 mg
T dc mi cam 200,00 mg
Kollidon VA 64 400,00 mg
Ethanol hoc isopropanol
1,40 ml

THUC CM PHA SIRO NHM HYDROXYD

V MAGNESI CARBONAT
Gel kh nhm hydroxyd

200,00 g

Magnesi carbonat base

200,00 g

Kollidon CL-M 240,00 g

Sorbitol, tinh th

211,50 g

T dc mi cam 41,30 g
Kollidon 30 82,60 g
T dc mi da 3,30 g
T dc mi chui 4,13 g
Natri saccarin

4,13 g

Nc tinh khit 8,26 g

PELLET
PELLET

B phn n

a to cu

Thit b n to cu

S thit b tng si