Professional Documents
Culture Documents
Akbar
Department of Physiology
Faculty Of Medicine Universitas Islam Bandung
I. INTRODUCTION
Neuroendocrinology
The interaction between the central
nervous system (CNS) and endocrine
systems in the control of homeostasis
The control of pituitary hormone secretion
by the hypothalamus
The fundamental role of the hypothalamus
in controlling anterior pituitary function.
The Endocrine
System
Synthesis,
storage and
release of
posterior
pituitary
hormone
Hypothalamic
and pituitary
hormones
A complex
endocrine
pathway
Brain
Postganglionic sympathetic
neuron
Sympathetic
ganglia
Preganglionic
sympathetic
neuron
Adrenal
glands
Sympathetic
ganglia
Medulla
Blood
Epinephrine
Various
effector
organs
NE
Heart
A. Human hypothalamic
Pituitary unit
B. Midsaggital nuclear
Magnetic resonance scan
of the brain of a normal
woman
IV. CIRCUMVENTRICULAR
ORGAN
a. Median eminence
The median eminence and
neurohypophysis contain the
secretory axons that control pituitary
function
Hypothalamic
magnocellular neurons
and the posterior pituitary
gland
c. Area postrema
d. Subcommissural organ
V. HYPOPHYSEOTROPIC
HORMONES
NEUROENDOCRINE
AXES
a. AND
Feedback
concepts in neuroendocrinology
b. Endocrine rhythms
c. Thyrotropin-releasing hormone
- Chemistry and evolution
- Clinical applications
- Regulating of thyrotropin release
- Feedback control : Pituitary-Thyroid Axis
- Neural control : Circadian rhythm,
Temperature, Starvation, Infection and
inflammation
d. Corticotropin-releasing hormone
- Chemistry and evolution
- Effect on the pituitary and mechanism of
action
- Clinical applications
- Feedback control
- Neural control
- Other factors influencing secretion of
corticotropin : Circadian rhythm,
corticotropin release-inhibiting factor
Neuroendocrine
regulation of growth
hormone secretion
- Neural control
f. Somatostatin
- Chemistry and evolution
- Somatostatin receptors
- Effect on target tissues and mechanism of
action
- Clinical applications of somatostatin
analogues
g. Prolactin-regulating factors
- Dopamine
- Prolactin-releasing factors
- Intrapituitary regulation of prolactin
secretion
- Neuroendocrine regulation of prolactin
secretion
- Feedback control
- Neural control
- Factors influencing secretion
j. Neuroendocrine-immune interactions
- Cytokines signal the central nervous
system
- Interaction of cytokines with the
circumventricular organs
- Interaction of cytokines at the barriers of
the brain
- Entry of cytokines into the brain
- Interaction of cytokines with peripheral
nerves
- Cell groups throughout the brain
responsive to cytokines
VI. NEUROENDOCRINE
a.
Pituitary isolation syndrome
DISEASE
b.
c.
d.