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Neutrophil
Basophil
Eosinophil
2-4% of all WBCs
Anatomy
10-12 m diameter
2 connected nuclear
lobes
Red/orange large,
uniform granules, do
not obscure the
nucleus
Physiology
Exit capillaries, enter
tissue fluid
combat
parasites
histamine
Phagocytize antigen-
antibody complexes
Neutrophil
60-70% of all WBCs
Anatomy
10-12 m diameter
2-6 nuclear lobes
Fine, pale inconspicuous
granules
Physiology
Respond first to bacteria
damage by chemotaxis
Phagocytosis
After engulfing pathogen
releases several
chemicals
lysozyme
strong oxidants
defensins
Eosinophil
2-4% of all WBCs
Anatomy
10-12 m diameter
2 connected nuclear
lobes
Red/orange large,
uniform granules, do
not obscure the
nucleus
Physiology
Exit capillaries, enter
tissue fluid
combat
parasites
histamine
Phagocytize antigen-
antibody complexes
Basophil
0.5-1% of all WBCs
Anatomy
8-10 m diameter
Bilobed or irregular
nucleus
Granules round, blue-
black, may obscure the
nucleus
Physiology
Exit caps enter tissue
fluids
Change into mast cells
release heparin,
histamine, serotonin
stimulate inflammation
Hypersensitivity
(allergic) reactions
Agranular Leukocytes
Lymphocyte
Monocyt
e
Lymphocytes
20-25% of all
WBCs
Anatomy
7-15m
nucleus dark
stained, round or
indented
cytoplasm a pale
blue rim around
the nucleus
Monocytes
3-8% of all WBCs
Anatomy
14-19 m
indented or kidney-
shaped nucleus (not
round)
cytoplasm foamy
Physiology
Physiology
Short life span (5-9
days)
Help plug small holes
in blood vessels
Granules contain
regulatory factors
which serve several
important functions in:
coagulation
inflammation
immune defenses