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pulmonary arterial
hypertension
NURAMALINA BINTI REMAN
112016183
DR. RETNA DEWAYANI, SP. JP
Definition
Epoprostenol
Short acting sodium salt, intravenous
Improve haemodynamic, six-minute walk, survival
Side effect : route of administration (infection,
thrombosis,embolism,leakage and pneumothorax)
Iloprost
Longer half life (120 minute)
Nebulizer (pulmonary selectivity and avoid systemic hypotension)
Adjunctive therapy
Treatment
3. Endothelin-receptor antagonist
Bosentan
Orally active dual receptor blocker (ET4 and ET8)
Initiation of treatment at an early stage
Hepatic dysfunction and teratogenic
Ambrisentan
Macitentan
4. Phophodiesterase inhibitor
Sildenafil : specific phosphodiesterase type-5
Side effect : flushing, epistaxis, heartburn, headache, interaction with
other drugs (bosentan and nitrates)
6. Prostacyclin-receptor agonist
Selexipag : target the same receptor as PGI2, but structurally
different
Side effect : headache, jaw pain, GI upset
Conclusion