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PHYSIOLOGY
WHAT IS SYNTHETIC
PHYSIOLOGY?
OPTOGENETIC
S
SYNTHETIC
PHYSIOLOGY
SYNTHETIC
PHYSIOLOGY
OPTOGENICS
Combination of genetic and optical methods to control
specific events in targeted cells of living tissue.
Melanopsin
=
Trigger the opening
First signalling cascade of transient receptor
activated : Gaq, PLC & PKC potential channels,
allowing influx of
Ca2+
The Pathway
2) Intracellular Ca2+ surge activates transcription factor,
nuclear factor of activated T cells (NFAT)
activates
Ca2+ + Calmodulin (calcium sensor) Calcineurin
dephosphorylates
Activated Calcineurin NFAT
The Pathway
3) Dephosphorylated NFAT
enters the nucleus and
binds to specific promotors
(PNFAT), inducing gene
expression
Applications
Preclinial
Bioengineering
Possible cure for diabetes?
NFAT-dependent promoter: gene encoding GLP-1
Physiological functions:
Glucose homeostasis
Stimulation of
insulin secretion (Decrease in blood
glucose concentration)
Possible cures for diabetes?
Study conducted by Haifeng Ye from Swiss
Federal Institute of Technology Zurich