Professional Documents
Culture Documents
Windy Juliandra
M. Arsyi
Components of the Immune
System
Nonspecific Specific
complement,
macrophages, T cells; other
interferon, antibodies
neutrophils effectors cells
TNF etc.
Spontaneous regression
Regression of metastases after removal of
primary tumor
Regression after chemotherapy
Infiltration of tumors by lymphocytes and
macrophages
Lymphocyte proliferation in draining lymph
nodes
Higher incidence of cancer after
immunosuppression/immunodeficiency (AIDS,
neonates, aged, transplant patients)
•Immunosurveillance - the tumor-
suppressing role of the immune system.
13
Lack of
co-stimulatory
molecules
14
Lack of
class I MHC
15
Tumors secrete
Immunosuppressive
molecules
16
Tumors shed their
neo-antigens
17
4) B-cells :
- Tumor associated antigens stimulate production of specific antibodies
by host B-cells
- These specific antibodies bind together on tumor cell surface
leading to destruction of tumor through:
a- Antibody mediated-cytotoxicity :
kill
Cytotoxic T-cells IgG-coated tumor cells
b- Activation of macrophages
release
Sensitized T-cells macrophage activating factor
IgG-coated tumor cells macrophages activate
Tumor antigens
* They are either or
Tumor products
(enzymes and hormones)
b) Enzymes :
- Acid phosphatase enzymes in cases of cancer prostae
24
25
active immunotherapy
specific killed tumor cells, purified or
recombinant Ag
non- BCG, Propionibacterium acne,
specific levamisole, etc.
passive immunotherapy
non-specific LAK cells, cytokines
26
Modification by gene transfer
Obj: selectively induced T-cell mediated
immune response stimulate the local growth
of T cells or dendritic cells y the secretion of
cytokines (IL-2, IL-4, IL-7, Gm-CSF)
Systemic administration of cytokines