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M.KINNERA (153H1R0046)
M.JANAKI RAM (153H1R0047)
M.RATNA BHAVANI (153H1R0048)
M.V.S.MANVITHA (153H1R0049)
Urea and PEG 4000 in proportions viz. 1:1, 1:2, 1:3, 1:4
(Drug: Carrier)
• Flow properties
2
• Drug content
3
1 PD 100
SDUF1
2 1:1 96.4
SDUF2
3 1:2 97.6 PD-PURE DRUG
SDPF1
6 1:1 98.8
SDPF2
7 1:2 97.8
SDPF3
8 1:3 99.5
SDPF4
9 1:4 97.4
USP type I Dissolution Testing Apparatus (LABINDIA )
Dissolution medium - phosphate buffer pH 6.8
Volume – 900ml
RPM – 50 , Temperature - 37 ̊C±0.5 ̊C
Sampling intervels-5,10,15,20,30,45,60,90 mins
Sample volume:5ml withdrawn at fixed time intervals &
replaced with 5ml of pH 6.8 phosphate buffer.
analyzed spectrophotometrically at 232nm
Time SDUF1 SDUF2 SDUF3 SDUF4 SDPF1 SDPF2 SDPF3 SDPF4
PD
(min)
5 9.7 18 22 30 32 17 20 19 29
10 18.6 29 35 42 46 28 31 30 37
15 24.8 36 44 56 54 36 37 39 46
20 28.1 49 53 68 69 44 45 47 55
30 30.3 63 67 82 80 57 59 65 68
45 35.5 75 80 89 97 63 66 72 80
60 37.3 87 89 94 97 72 79 85 99
90 42.2 88 91 93 96
PD-pure drug
SDUF-solid dispersion urea formulation
SDPF-solid dispersion PEG formulation
Fig:- 1 Comparison of Dissolution Profiles of
SolidDispersions of UREA and Pure Drug
Maximum solubility exhibiting ratio :-1:4 Maximum solubility exhibiting ratio : 1:4
But more than urea.
Drug release kinetics:- zero order Drug release kinetics:- zero order