Influenza

Dr.T .V.R ao MD
Influenza Virus belong to
Myxovirus

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 INFLUENZA
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Major pandemic in 1918 – 1919

 Scientific contributions

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 WHO defines Influenza
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 Spread of Influenza
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 Classification of Influenza
virus

What are A B C
 Reservoirs of Virus
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 Influenza Vi rus

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Viral structure

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 A negative sense
Single stranded
RNA genome is
segmented into 8
segments
 Vi ra l str uct ur e
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 Resistance of Virus

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Prominent Characters of the
Virus
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 Hemagglu tinatio n

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 Antigenic Structure
Influenza virus

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tination
 Types of
Haemagglutinnins
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 Neu ra mi ni das es
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 Ant igen ic Var iat ion

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 Influenza prominent
Antigenic Changes
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Ant igen ic Var iat ions
 Antigen ic D rift
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 Antigenic Shift
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Antigenic shift initiates
Pandemics
Mechani sm of
Ant ig eni c Shi ft
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 Hos t Range

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 Pa th oge ne sis
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Infection of cell in
Influenza virus
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Viral Pneumonia is Leading cause of
Death
 Complications of
Influenza
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 Complication in
Influenza
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 Influenza Diagnosis
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Isolation of Virus
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 Testing on paired sera
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 Immunity

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 Original Antigenic sin
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10 million dead in India

 UMass-Amherst, 1957

H3N2 Seasonal Flu

H2N2
H1N1 Seasonal Flu H1N1 Seasonal Flu
 Maj or recent
Major Pandemi cs
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 BIRD FLU
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Bird flu can spread from
Birds to Humans
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 New strain Hon Kong
H5 N1 strain

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 Wild Birds Migrate and
spread the Disease Globally
 How Pandemics are
Produced

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Cycle of Events on spread

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 Migratory
Birds
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happen with H5
N1
Culling is the early option in
control of Influenza
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 Prevention

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 Vaccine

Cock tail vacci ne con tains one or

two types of A and type B vir us
of t he pr eviou s win ter m onths .
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 Recombinant
vaccines
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 Inf luenza V acci ne
Reco mm enda ti ons
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Indi cat ion to Vacc inat e

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 Emerging trends in
Vaccines