Professional Documents
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Immunology 101
Our immune system is able to recognize and fight bugs that do not look like self
cellular
humoral
B cell (antibody maker)
IgG IgA
Thibodeau GA, Patton KT: Anatomy and physiology, ed 7, St Louis, 2010, Mosby.
Immunologic memory
From georgiangentleman.posterous.com
vaccine
Antibodies can only see the envelope protein on the incoming virus, so envelope is essential for neutralization T cells can see all parts of HIV, but some proteins seem to be better targets for T cells than others
other
Our immune system is very specific, and vaccine-induced antibodies or T cells may not recognize a strain of HIV
The durability of the vaccine-induced immune response wanes over time using current candidates
strains (e.g. Gag for T cells, V2 or CD4 binding site for Ab)