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• Location
• Thorax between the lungs
• Pointed apex directed toward left hip
• About the size of your fist
Figure 11.1
Figure 11.3
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.7
The Heart: Valves
• Allow blood to flow in only one direction
• Four valves
• Atrioventricular valves – between atria and
ventricles
• Bicuspid valve (left)
• Tricuspid valve (right)
• Semilunar valves between ventricle and
artery
• Pulmonary semilunar valve
• Aortic semilunar valve
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.8
The Heart: Valves
Figure 11.4
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.10
The Heart: Associated Great Vessels
• Aorta
• Leaves left ventricle
• Pulmonary arteries
• Leave right ventricle
• Vena cava
• Enters right atrium
• Pulmonary veins (four)
• Enter left atrium
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.11
Coronary Circulation
Figure 11.5
Figure 11.6
Figure 11.7
Slide 11.22
Blood Vessels: The Vascular
System
Figure 11.8b
Figure 11.9
• Capillary beds
consist of two
types of vessels
• Vascular shunt –
directly connects an
arteriole to a venule
Figure 11.11
Figure 11.12
Figure 11.13
Figure 11.14
Slide 11.34
Highly oxygenated blood from the placenta
enters the fetus via the umbilical vein. A
large proportion of this blood passes into
the liver to supply the hepatic sinusoids.
The remainder bypasses the liver in the
ductus venosus, drains into caudal vena
cava and mixes with poorly oxygenated
blood returning from the fetal body. The
blood in the caudal vena cava, which,
although mixed is still well oxygenated,
drains into the right atrium of the heart.
Most of the blood entering the right atrium
from the caudal vena cava is directed
through the foramen ovale into the left
atrium where it is mixed with a small
amount of deoxygenated blood returning
from the lungs. The contents of the left
atrium enter the left ventricle and are
expelled from the heart into the aorta.
The contents of the right atrium (which consist of some well
oxygenated blood from the caudal vena cava and poorly
oxygenated blood returning from the head and forelimbs via the
cranial vena cava) enter the right ventricle and are expelled
from the heart via the pulmonary artery. Only approximately 5
-10% of the blood in the pulmonary artery enters the lungs in the
fetus due to the high resistance of their collapsed, non-aerated
state. The remainder enters the ductus arteriosus which is a
shunt linking the pulmonary artery and the aorta. The
convergence of the poorly oxygenated pulmonary blood and the
well-oxygenated aortic blood occurs after the main supply to the
head and forelimbs have branched off the aortic arch. This
ensures that the blood richest in oxygen reaches the developing
brain.
The abdominal aorta supplies the rest of the body and gives off
two umbilical arteries (branches of the internal iliac arteries)
which carry poorly oxygenated blood back to the placenta.
Changes at birth
At birth the lungs can inflate and perform their true function
meaning that the fetal bypass systems are no longer required.
•Umbilical vein - Constricts to form the ligamentum teres,
which extends from the umbilicus to the liver. The mesentery
that surrounded the umbilical vein becomes the falciform
ligament.
Ductus venosus - A sphincter in the ductus venosus
constricts so that all blood entering the liver passes through
the hepatic sinusoids.
Foramen ovale - Due to aeration of the lungs, pulmonary
resistance decreases and pulmonary blood flow increases.
The increase in pulmonary blood flow causes the
pressure in the left atrium to raise above that of the right
which results in the valve of the foramen ovale being
pushed against the septum secundum. This closes the
foramen ovale and its vestge is known as the fossa ovale.
Ductus arteriosus - The change in the partial pressure of
oxygen in the blood once the lungs become functional
controls the constriction of the ductus arteriosus. Closure
of the duct is usually complete soon after birth and its
remnant is known as the ligamentum arteriosus.
Umbilical arteries - The intra-abdominal portions of the
umbilical arteries constrict. Some parts remain patent
supplying the urinary bladder and these are contained
within the lateral vesicle ligaments which are vestiges of
the mesetery surrounding the umbilical arteries.
Pulse
• Pulse –
pressure wave
of blood
• Monitored at
“pressure
points” where
pulse is easily
palpated
Figure 11.16
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.35
Blood Pressure
• Measurements by health professionals
are made on the pressure in large
arteries
• Systolic – pressure at the peak of
ventricular contraction
• Diastolic – pressure when ventricles relax
• Pressure in blood vessels decreases as
the distance away from the heart
increases
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.36
Blood Pressure: Effects of Factors
• Neural factors
• Autonomic nervous system adjustments
(sympathetic division)
• Renal factors
• Regulation by altering blood volume
• Renin – hormonal control
• Temperature
• Heat has a vasodilation effect
• Cold has a vasoconstricting effect
• Chemicals
• Various substances can cause increases or
decreases
• Diet
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.39b
Factors Determining Blood Pressure
Figure 11.19
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.40
Variations in Blood Pressure
• Human normal range is variable
• Normal
• 140–110 mm Hg systolic
• 80–75 mm Hg diastolic
• Hypotension
• Low systolic (below 110 mm HG)
• Often associated with illness
• Hypertension
• High systolic (above 140 mm HG)
• Can be dangerous if it is chronic
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 11.41
Developmental Aspects of the
Cardiovascular System
Description
This image shows clearly the damage caused by a heart attack.
To the right of the image, you can see the back wall of the left
ventricle where there is an extensive area of dead tissue
(infarct).
The central part of the infarct shows the yellow appearance of
dead tissue (necrosis), and bordering on this is an outer reddish
area which suggests partial healing by early scar tissue. The
front wall of the left ventricle (on the left of the image) appears
normal.
Where the reddish area curves around the yellow dead tissue at
the top, you can see the right coronary artery, which is
considerably narrowed due to artherosclerosis (hardening of the
artery walls). A blood clot has formed in this narrowed area and
was responsible for the heart attack.
Atherosclerosis is responsible for the majority of
deaths in our society. It is also responsible for a
huge amount of morbidity.
If one studies insurance tables, atherosclerosis
causes a large contribution to years of potential life
lost.
Atherosclerosis is predominantly a disease of
arteries – both large and medium-sized.
It affects elastic and muscular vessels.
Atherosclerosis may also involve veins when they
become vein grafts and are exposed to arterial
pressure.
Risk factors for atherosclerosis include those, which
are modifiable, and those, which are not.